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Prevalence and distribution of the GBV-C/HGV among HIV-1-infected patients under anti-retroviral therapy.
Virus Res. 2010 Aug; 151(2):148-52.VR

Abstract

Infection with GB virus C (GBV-C) or hepatitis G virus (HGV) is highly prevalent among HIV/AIDS patients. GBV-C/HGV viremia has not been associated with liver disease and seems to slow HIV disease progression. To study the GBV-C/HGV genotypes prevalence among HIV/AIDS patients and its association with HIV viral load (VL) and CD4+ lymphocyte counts. From February 2003 to February 2004, we analyzed 210 HIV-1-infected subjects who were on anti-retroviral therapy (ART). For 63 of them a PCR-nested to the non-coding 5' (5'NCR) region of the GBV-C/HGV was done, and for 49 a DNA direct sequencing was done. A phylogenetic analysis was performed by PHYLIP program. 63 (30%) of the HIV-1-infected patients were co-infected with GBV-C/HGV. The phylogenetic analysis revealed the following genotypes (and respective relative frequencies): 1 (10%), 2a (41%), 2b (43%), and 3 (6%). Co-infected patients presented lower HIV-1 VL and higher T CD4+ lymphocyte cells counts as compared with patients negative for GBV-C/HGV sequences (log=4.52 vs. 4.71, p=0.036), and T CD4+ lymphocyte counts (cells/mm(3)=322.6 vs. 273.5, p=0.081, respectively). T CD4+ cells counts equal to, or higher than, 200/mm(3) were significantly more common among co-infected patients than among HIV-infected-only patients (p=0.042). The lowest T CD4+ cells counts were associated with genotype 1 and the highest with genotype 2b (p=0.05). The GBV-C/HGV infection prevalence was 30% among HIV-1-infected subjects, and was associated with lower VL and higher CD4+ lymphocyte counts. GBV-C/HGV genotype 2b may be associated with better immunological response.

Authors+Show Affiliations

Laboratory of Dermatology and Immunedeficiencies, University of São Paulo Medical School, São Paulo, Brazil. rosana fmusp@yahoo.com.brNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20420864

Citation

Alcalde, Rosana, et al. "Prevalence and Distribution of the GBV-C/HGV Among HIV-1-infected Patients Under Anti-retroviral Therapy." Virus Research, vol. 151, no. 2, 2010, pp. 148-52.
Alcalde R, Nishiya A, Casseb J, et al. Prevalence and distribution of the GBV-C/HGV among HIV-1-infected patients under anti-retroviral therapy. Virus Res. 2010;151(2):148-52.
Alcalde, R., Nishiya, A., Casseb, J., Inocêncio, L., Fonseca, L. A., & Duarte, A. J. (2010). Prevalence and distribution of the GBV-C/HGV among HIV-1-infected patients under anti-retroviral therapy. Virus Research, 151(2), 148-52. https://doi.org/10.1016/j.virusres.2010.04.008
Alcalde R, et al. Prevalence and Distribution of the GBV-C/HGV Among HIV-1-infected Patients Under Anti-retroviral Therapy. Virus Res. 2010;151(2):148-52. PubMed PMID: 20420864.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence and distribution of the GBV-C/HGV among HIV-1-infected patients under anti-retroviral therapy. AU - Alcalde,Rosana, AU - Nishiya,Anna, AU - Casseb,Jorge, AU - Inocêncio,Lilian, AU - Fonseca,Luiz A M, AU - Duarte,Alberto J S, Y1 - 2010/04/24/ PY - 2010/02/26/received PY - 2010/04/12/revised PY - 2010/04/15/accepted PY - 2010/4/28/entrez PY - 2010/4/28/pubmed PY - 2010/10/12/medline SP - 148 EP - 52 JF - Virus research JO - Virus Res VL - 151 IS - 2 N2 - Infection with GB virus C (GBV-C) or hepatitis G virus (HGV) is highly prevalent among HIV/AIDS patients. GBV-C/HGV viremia has not been associated with liver disease and seems to slow HIV disease progression. To study the GBV-C/HGV genotypes prevalence among HIV/AIDS patients and its association with HIV viral load (VL) and CD4+ lymphocyte counts. From February 2003 to February 2004, we analyzed 210 HIV-1-infected subjects who were on anti-retroviral therapy (ART). For 63 of them a PCR-nested to the non-coding 5' (5'NCR) region of the GBV-C/HGV was done, and for 49 a DNA direct sequencing was done. A phylogenetic analysis was performed by PHYLIP program. 63 (30%) of the HIV-1-infected patients were co-infected with GBV-C/HGV. The phylogenetic analysis revealed the following genotypes (and respective relative frequencies): 1 (10%), 2a (41%), 2b (43%), and 3 (6%). Co-infected patients presented lower HIV-1 VL and higher T CD4+ lymphocyte cells counts as compared with patients negative for GBV-C/HGV sequences (log=4.52 vs. 4.71, p=0.036), and T CD4+ lymphocyte counts (cells/mm(3)=322.6 vs. 273.5, p=0.081, respectively). T CD4+ cells counts equal to, or higher than, 200/mm(3) were significantly more common among co-infected patients than among HIV-infected-only patients (p=0.042). The lowest T CD4+ cells counts were associated with genotype 1 and the highest with genotype 2b (p=0.05). The GBV-C/HGV infection prevalence was 30% among HIV-1-infected subjects, and was associated with lower VL and higher CD4+ lymphocyte counts. GBV-C/HGV genotype 2b may be associated with better immunological response. SN - 1872-7492 UR - https://www.unboundmedicine.com/medline/citation/20420864/Prevalence_and_distribution_of_the_GBV_C/HGV_among_HIV_1_infected_patients_under_anti_retroviral_therapy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-1702(10)00149-8 DB - PRIME DP - Unbound Medicine ER -