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The study of BDNF Val66Met polymorphism in Chinese schizophrenic patients.

Abstract

Accumulating evidence showed that brain-derived neurotrophic factor (BDNF) may be involved in the pathophysiology of schizophrenia. Recent studies have reported that the Val66Met polymorphism of the BDNF gene may be associated with susceptibility for schizophrenia and age of onset of this disease, with mix results. In the present study, the BDNF Val66Met gene polymorphism was examined in 387 inpatients (259 men and 128 women) meeting the DSM-IV criteria for schizophrenia and unrelated 365 healthy controls (255 men and 110 women). The schizophrenia symptomatology was assessed by the Positive and Negative Syndrome Scale (PANSS). Age of onset was defined as the age at which the psychotic symptoms first appeared. Our results showed that genotype frequency distributions and allelic frequencies did not differ between patients and controls. No interaction was found between sex and genotypes. Analysis of covariance (ANCOVA) showed a significance of the BDNF Val66Met genotypes on the age of onset (F=3.76, p<0.02), after adjusting sex, age and duration of illness. Furthermore, ANCOVA showed that the significance of the BDNFVal66Met genotypes on age of onset was increased comparing the Val66Met heterozygotes with the combination of Val66Val and Met66Met homozygotes (F=5.85, p<0.01). Our results suggest that the BDNF Val66Met polymorphism may not contribute directly to the susceptibility to schizophrenia, but to the onset of the disease. Furthermore, our results show the heterozygous effect of the BDNF Val66Met gene on the clinical variability of schizophrenia phenotype.

Authors+Show Affiliations

Department of Internal Medicine, Hebei Medical University, Shijiazhuang 050017, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20420877

Citation

Zhou, Dong Hao, et al. "The Study of BDNF Val66Met Polymorphism in Chinese Schizophrenic Patients." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 34, no. 6, 2010, pp. 930-3.
Zhou DH, Yan QZ, Yan XM, et al. The study of BDNF Val66Met polymorphism in Chinese schizophrenic patients. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34(6):930-3.
Zhou, D. H., Yan, Q. Z., Yan, X. M., Li, C. B., Fang, H., Zheng, Y. L., ... Zhang, X. Y. (2010). The study of BDNF Val66Met polymorphism in Chinese schizophrenic patients. Progress in Neuro-psychopharmacology & Biological Psychiatry, 34(6), pp. 930-3. doi:10.1016/j.pnpbp.2010.04.019.
Zhou DH, et al. The Study of BDNF Val66Met Polymorphism in Chinese Schizophrenic Patients. Prog Neuropsychopharmacol Biol Psychiatry. 2010 Aug 16;34(6):930-3. PubMed PMID: 20420877.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The study of BDNF Val66Met polymorphism in Chinese schizophrenic patients. AU - Zhou,Dong Hao, AU - Yan,Quan Zhi, AU - Yan,Xiao Mei, AU - Li,Cun Bao, AU - Fang,Hui, AU - Zheng,You Lan, AU - Zhang,Chong Xi, AU - Yao,Hui Jun, AU - Chen,Da Chun, AU - Xiu,Mei Hong, AU - Kosten,Thomas R, AU - Zhang,Xiang Yang, Y1 - 2010/04/24/ PY - 2010/01/06/received PY - 2010/04/14/revised PY - 2010/04/20/accepted PY - 2010/4/28/entrez PY - 2010/4/28/pubmed PY - 2010/11/3/medline SP - 930 EP - 3 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog. Neuropsychopharmacol. Biol. Psychiatry VL - 34 IS - 6 N2 - Accumulating evidence showed that brain-derived neurotrophic factor (BDNF) may be involved in the pathophysiology of schizophrenia. Recent studies have reported that the Val66Met polymorphism of the BDNF gene may be associated with susceptibility for schizophrenia and age of onset of this disease, with mix results. In the present study, the BDNF Val66Met gene polymorphism was examined in 387 inpatients (259 men and 128 women) meeting the DSM-IV criteria for schizophrenia and unrelated 365 healthy controls (255 men and 110 women). The schizophrenia symptomatology was assessed by the Positive and Negative Syndrome Scale (PANSS). Age of onset was defined as the age at which the psychotic symptoms first appeared. Our results showed that genotype frequency distributions and allelic frequencies did not differ between patients and controls. No interaction was found between sex and genotypes. Analysis of covariance (ANCOVA) showed a significance of the BDNF Val66Met genotypes on the age of onset (F=3.76, p<0.02), after adjusting sex, age and duration of illness. Furthermore, ANCOVA showed that the significance of the BDNFVal66Met genotypes on age of onset was increased comparing the Val66Met heterozygotes with the combination of Val66Val and Met66Met homozygotes (F=5.85, p<0.01). Our results suggest that the BDNF Val66Met polymorphism may not contribute directly to the susceptibility to schizophrenia, but to the onset of the disease. Furthermore, our results show the heterozygous effect of the BDNF Val66Met gene on the clinical variability of schizophrenia phenotype. SN - 1878-4216 UR - https://www.unboundmedicine.com/medline/citation/20420877/The_study_of_BDNF_Val66Met_polymorphism_in_Chinese_schizophrenic_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(10)00148-X DB - PRIME DP - Unbound Medicine ER -