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Hereditary and familial colon cancer.
Gastroenterology. 2010 Jun; 138(6):2044-58.G

Abstract

Between 2% to 5% of all colon cancers arise in the setting of well-defined inherited syndromes, including Lynch syndrome, familial adenomatous polyposis, MUTYH-associated polyposis, and certain hamartomatous polyposis conditions. Each is associated with a high risk of colon cancer. In addition to the syndromes, up to one-third of colon cancers exhibit increased familial risk, likely related to inheritance. A number of less penetrant, but possibly more frequent susceptibility genes have been identified for this level of inheritance. Clarification of predisposing genes allows for accurate risk assessment and more precise screening approaches. This review examines the colon cancer syndromes, their genetics and management, and also the common familial colon cancers with current genetic advances and screening guidelines.

Authors+Show Affiliations

Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Portrait
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

20420945

Citation

Jasperson, Kory W., et al. "Hereditary and Familial Colon Cancer." Gastroenterology, vol. 138, no. 6, 2010, pp. 2044-58.
Jasperson KW, Tuohy TM, Neklason DW, et al. Hereditary and familial colon cancer. Gastroenterology. 2010;138(6):2044-58.
Jasperson, K. W., Tuohy, T. M., Neklason, D. W., & Burt, R. W. (2010). Hereditary and familial colon cancer. Gastroenterology, 138(6), 2044-58. https://doi.org/10.1053/j.gastro.2010.01.054
Jasperson KW, et al. Hereditary and Familial Colon Cancer. Gastroenterology. 2010;138(6):2044-58. PubMed PMID: 20420945.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hereditary and familial colon cancer. AU - Jasperson,Kory W, AU - Tuohy,Thérèse M, AU - Neklason,Deborah W, AU - Burt,Randall W, PY - 2009/11/12/received PY - 2010/01/04/revised PY - 2010/01/11/accepted PY - 2010/4/28/entrez PY - 2010/4/28/pubmed PY - 2010/5/7/medline SP - 2044 EP - 58 JF - Gastroenterology JO - Gastroenterology VL - 138 IS - 6 N2 - Between 2% to 5% of all colon cancers arise in the setting of well-defined inherited syndromes, including Lynch syndrome, familial adenomatous polyposis, MUTYH-associated polyposis, and certain hamartomatous polyposis conditions. Each is associated with a high risk of colon cancer. In addition to the syndromes, up to one-third of colon cancers exhibit increased familial risk, likely related to inheritance. A number of less penetrant, but possibly more frequent susceptibility genes have been identified for this level of inheritance. Clarification of predisposing genes allows for accurate risk assessment and more precise screening approaches. This review examines the colon cancer syndromes, their genetics and management, and also the common familial colon cancers with current genetic advances and screening guidelines. SN - 1528-0012 UR - https://www.unboundmedicine.com/medline/citation/20420945/Hereditary_and_familial_colon_cancer_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0016-5085(10)00168-X DB - PRIME DP - Unbound Medicine ER -