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Reactive oxygen species: stuck in the middle of neurodegeneration.
J Alzheimers Dis. 2010; 20 Suppl 2:S357-67.JA

Abstract

Neuronal cell loss associated with neurodegeneration has recently been linked to mitochondrial dysfunction. Electron transport chain defects and reactive oxygen species (ROS) production are emerging as important players in the etiology of neurodegenerative diseases. Proper management of ROS and disposal of damaged cellular components are vital to the survival and function of neurons. Proteins involved in these pathways are often mutated in neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and Huntington's disease. In this review, we will discuss the roles of ROS in normal physiology, how changes in ROS production affect neuronal survival in neurodegenerative diseases, and the recent advances in mitochondrial antioxidants as potential therapeutics.

Authors+Show Affiliations

Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

20421690

Citation

Patten, David A., et al. "Reactive Oxygen Species: Stuck in the Middle of Neurodegeneration." Journal of Alzheimer's Disease : JAD, vol. 20 Suppl 2, 2010, pp. S357-67.
Patten DA, Germain M, Kelly MA, et al. Reactive oxygen species: stuck in the middle of neurodegeneration. J Alzheimers Dis. 2010;20 Suppl 2:S357-67.
Patten, D. A., Germain, M., Kelly, M. A., & Slack, R. S. (2010). Reactive oxygen species: stuck in the middle of neurodegeneration. Journal of Alzheimer's Disease : JAD, 20 Suppl 2, S357-67. https://doi.org/10.3233/JAD-2010-100498
Patten DA, et al. Reactive Oxygen Species: Stuck in the Middle of Neurodegeneration. J Alzheimers Dis. 2010;20 Suppl 2:S357-67. PubMed PMID: 20421690.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reactive oxygen species: stuck in the middle of neurodegeneration. AU - Patten,David A, AU - Germain,Marc, AU - Kelly,Melissa A, AU - Slack,Ruth S, PY - 2010/4/28/entrez PY - 2010/4/28/pubmed PY - 2010/9/14/medline SP - S357 EP - 67 JF - Journal of Alzheimer's disease : JAD JO - J. Alzheimers Dis. VL - 20 Suppl 2 N2 - Neuronal cell loss associated with neurodegeneration has recently been linked to mitochondrial dysfunction. Electron transport chain defects and reactive oxygen species (ROS) production are emerging as important players in the etiology of neurodegenerative diseases. Proper management of ROS and disposal of damaged cellular components are vital to the survival and function of neurons. Proteins involved in these pathways are often mutated in neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and Huntington's disease. In this review, we will discuss the roles of ROS in normal physiology, how changes in ROS production affect neuronal survival in neurodegenerative diseases, and the recent advances in mitochondrial antioxidants as potential therapeutics. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/20421690/Reactive_oxygen_species:_stuck_in_the_middle_of_neurodegeneration_ L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/JAD-2010-100498 DB - PRIME DP - Unbound Medicine ER -