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[Deep brain stimulation for Parkinson's disease].
Nervenarzt. 2010 Jun; 81(6):669-79.N

Abstract

Deep brain stimulation (DBS) is an effective neurosurgical therapy for treatment of motor symptoms in Parkinson's disease (PD). DBS of the subthalamic nucleus (STN-DBS) leads to a significant reduction of hypokinetic and hyperkinetic symptoms and improvement in quality of life. STN-DBS is, however, associated with severe adverse effects including psychiatric symptoms, such as depression, apathy and increased suicidal tendencies. Pallidal DBS might be just as efficacious with fewer adverse effects. Future studies will prospectively compare the clinical effects of STN and pallidal DBS. Alternative targets for treatment of PD have to be considered including the pedunculopontine nucleus, thalamic CM/Pf complex and zona incerta.

Authors+Show Affiliations

Klinik für Neurologie, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Schittenhelmstrasse 10, Kiel, Germany.No affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

ger

PubMed ID

20422148

Citation

Herzog, J, and G Deuschl. "[Deep Brain Stimulation for Parkinson's Disease]." Der Nervenarzt, vol. 81, no. 6, 2010, pp. 669-79.
Herzog J, Deuschl G. [Deep brain stimulation for Parkinson's disease]. Nervenarzt. 2010;81(6):669-79.
Herzog, J., & Deuschl, G. (2010). [Deep brain stimulation for Parkinson's disease]. Der Nervenarzt, 81(6), 669-79. https://doi.org/10.1007/s00115-010-2938-3
Herzog J, Deuschl G. [Deep Brain Stimulation for Parkinson's Disease]. Nervenarzt. 2010;81(6):669-79. PubMed PMID: 20422148.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Deep brain stimulation for Parkinson's disease]. AU - Herzog,J, AU - Deuschl,G, PY - 2010/4/28/entrez PY - 2010/4/28/pubmed PY - 2010/10/23/medline SP - 669 EP - 79 JF - Der Nervenarzt JO - Nervenarzt VL - 81 IS - 6 N2 - Deep brain stimulation (DBS) is an effective neurosurgical therapy for treatment of motor symptoms in Parkinson's disease (PD). DBS of the subthalamic nucleus (STN-DBS) leads to a significant reduction of hypokinetic and hyperkinetic symptoms and improvement in quality of life. STN-DBS is, however, associated with severe adverse effects including psychiatric symptoms, such as depression, apathy and increased suicidal tendencies. Pallidal DBS might be just as efficacious with fewer adverse effects. Future studies will prospectively compare the clinical effects of STN and pallidal DBS. Alternative targets for treatment of PD have to be considered including the pedunculopontine nucleus, thalamic CM/Pf complex and zona incerta. SN - 1433-0407 UR - https://www.unboundmedicine.com/medline/citation/20422148/[Deep_brain_stimulation_for_Parkinson's_disease]_ L2 - https://dx.doi.org/10.1007/s00115-010-2938-3 DB - PRIME DP - Unbound Medicine ER -