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Traditional Chinese Medicine for treatment of fibromyalgia: a systematic review of randomized controlled trials.
J Altern Complement Med. 2010 Apr; 16(4):397-409.JA

Abstract

BACKGROUND

Traditional Chinese Medicine (TCM) is popular for treatment of fibromyalgia (FM) although there is a lack of comprehensive evaluation of current clinical evidence for TCM's therapeutic effect and safety.

OBJECTIVE

To review systematically the beneficial and harmful effects of TCM therapies for FM.

METHODS

We searched six English and Chinese electronic databases for randomized clinical trials (RCTs) on TCM for treatment of FM. Two authors extracted data and assessed the trial quality independently. RevMan 5 software was used for data analyses with an effect estimate presented as mean difference (MD) with a 95% confidence interval (CI).

RESULTS

Twenty-five RCTs were identified with 1516 participants for this review. Seven trials (28%) were evaluated as having a low risk of bias and the remaining trials were identified as being as unclear or having a high risk of bias. Overall, ten trials were eligible for the meta-analysis, and data from remaining 15 trials were synthesized qualitatively. Acupuncture reduced the number of tender points (MD, -3.21; 95% CI -4.23 to -2.11; p < 0.00001, I(2) = 0%), and pain scores compared with conventional medications (MD, -1.78; 95% CI, -2.24 to -1.32; p < 0.00001; I(2) = 0%). Acupuncture showed no significant effect, with a random-effect model, compared with sham acupuncture (MD, -0.55; 95% CI, -1.35-0.24; p = 0.17; I(2) = 69%), on pain reduction. A combination of acupuncture and cupping therapy was better than conventional medications for reducing pain (MD, -1.66; 95% CI, -2.14 to -1.19; p < 0.00001; I(2) = 0%), and for improving depression scores with related to FM (MD, -4.92; 95% CI, -6.49 to -3.34; p < 0.00001; I(2) = 32%). Other individual trials demonstrated positive effects of Chinese herbal medicine on pain reduction compared with conventional medications. There were no serious adverse effects reported that were related to TCM therapies in these trials.

CONCLUSIONS

TCM therapies appear to be effective for treating FM. However, further large, rigorously designed trials are warranted because of insufficient methodological rigor in the included trials.

Authors+Show Affiliations

Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

20423209

Citation

Cao, Huijuan, et al. "Traditional Chinese Medicine for Treatment of Fibromyalgia: a Systematic Review of Randomized Controlled Trials." Journal of Alternative and Complementary Medicine (New York, N.Y.), vol. 16, no. 4, 2010, pp. 397-409.
Cao H, Liu J, Lewith GT. Traditional Chinese Medicine for treatment of fibromyalgia: a systematic review of randomized controlled trials. J Altern Complement Med. 2010;16(4):397-409.
Cao, H., Liu, J., & Lewith, G. T. (2010). Traditional Chinese Medicine for treatment of fibromyalgia: a systematic review of randomized controlled trials. Journal of Alternative and Complementary Medicine (New York, N.Y.), 16(4), 397-409. https://doi.org/10.1089/acm.2009.0599
Cao H, Liu J, Lewith GT. Traditional Chinese Medicine for Treatment of Fibromyalgia: a Systematic Review of Randomized Controlled Trials. J Altern Complement Med. 2010;16(4):397-409. PubMed PMID: 20423209.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Traditional Chinese Medicine for treatment of fibromyalgia: a systematic review of randomized controlled trials. AU - Cao,Huijuan, AU - Liu,Jianping, AU - Lewith,George T, PY - 2010/4/29/entrez PY - 2010/4/29/pubmed PY - 2010/10/1/medline SP - 397 EP - 409 JF - Journal of alternative and complementary medicine (New York, N.Y.) JO - J Altern Complement Med VL - 16 IS - 4 N2 - BACKGROUND: Traditional Chinese Medicine (TCM) is popular for treatment of fibromyalgia (FM) although there is a lack of comprehensive evaluation of current clinical evidence for TCM's therapeutic effect and safety. OBJECTIVE: To review systematically the beneficial and harmful effects of TCM therapies for FM. METHODS: We searched six English and Chinese electronic databases for randomized clinical trials (RCTs) on TCM for treatment of FM. Two authors extracted data and assessed the trial quality independently. RevMan 5 software was used for data analyses with an effect estimate presented as mean difference (MD) with a 95% confidence interval (CI). RESULTS: Twenty-five RCTs were identified with 1516 participants for this review. Seven trials (28%) were evaluated as having a low risk of bias and the remaining trials were identified as being as unclear or having a high risk of bias. Overall, ten trials were eligible for the meta-analysis, and data from remaining 15 trials were synthesized qualitatively. Acupuncture reduced the number of tender points (MD, -3.21; 95% CI -4.23 to -2.11; p < 0.00001, I(2) = 0%), and pain scores compared with conventional medications (MD, -1.78; 95% CI, -2.24 to -1.32; p < 0.00001; I(2) = 0%). Acupuncture showed no significant effect, with a random-effect model, compared with sham acupuncture (MD, -0.55; 95% CI, -1.35-0.24; p = 0.17; I(2) = 69%), on pain reduction. A combination of acupuncture and cupping therapy was better than conventional medications for reducing pain (MD, -1.66; 95% CI, -2.14 to -1.19; p < 0.00001; I(2) = 0%), and for improving depression scores with related to FM (MD, -4.92; 95% CI, -6.49 to -3.34; p < 0.00001; I(2) = 32%). Other individual trials demonstrated positive effects of Chinese herbal medicine on pain reduction compared with conventional medications. There were no serious adverse effects reported that were related to TCM therapies in these trials. CONCLUSIONS: TCM therapies appear to be effective for treating FM. However, further large, rigorously designed trials are warranted because of insufficient methodological rigor in the included trials. SN - 1557-7708 UR - https://www.unboundmedicine.com/medline/citation/20423209/Traditional_Chinese_Medicine_for_treatment_of_fibromyalgia:_a_systematic_review_of_randomized_controlled_trials_ L2 - https://www.liebertpub.com/doi/10.1089/acm.2009.0599?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -