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Ameliorative effect of a hippocampal metabotropic glutamate- receptor agonist on histamine H1 receptor antagonist-induced memory deficit in rats.
J Pharmacol Sci. 2010; 113(1):41-7.JP

Abstract

This study was performed to investigate the ameliorative effects of metabotropic glutamate (mGlu)-receptor agonists on histamine H(1) receptor antagonist-induced spatial memory deficit and the decrease in hippocampal theta activity in rats. Intraperitoneal injection of pyrilamine (35 mg/kg) resulted in impaired reference and working memory in the radial maze task and decreased hippocampal theta amplitude and power. The working memory deficit and decreased hippocampal theta power induced by pyrilamine were ameliorated by intrahippocampal injection of (RS)-3,5-dihydroxyphenylglycine (DHPG) (1 and 10 microg/side), a group I mGlu-receptor agonist; however, intrahippocampal injection of (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate (APDC), a group II mGlu-receptor agonist, and L-(+)-2-amino-4-phosphonobutyric acid (L-AP4), a group III mGlu-receptor agonist, showed no significant effect on the pyrilamine-induced memory deficit and decreased hippocampal theta activity. These results indicate that the activation of hippocampal group I mGlu receptors, but not group II and III mGlu receptors, improve the histamine H(1) receptor antagonist-induced working memory deficit and decreased hippocampal theta activity.

Authors+Show Affiliations

Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20424385

Citation

Masuoka, Takayoshi, et al. "Ameliorative Effect of a Hippocampal Metabotropic Glutamate- Receptor Agonist On Histamine H1 Receptor Antagonist-induced Memory Deficit in Rats." Journal of Pharmacological Sciences, vol. 113, no. 1, 2010, pp. 41-7.
Masuoka T, Mikami A, Kamei C. Ameliorative effect of a hippocampal metabotropic glutamate- receptor agonist on histamine H1 receptor antagonist-induced memory deficit in rats. J Pharmacol Sci. 2010;113(1):41-7.
Masuoka, T., Mikami, A., & Kamei, C. (2010). Ameliorative effect of a hippocampal metabotropic glutamate- receptor agonist on histamine H1 receptor antagonist-induced memory deficit in rats. Journal of Pharmacological Sciences, 113(1), 41-7.
Masuoka T, Mikami A, Kamei C. Ameliorative Effect of a Hippocampal Metabotropic Glutamate- Receptor Agonist On Histamine H1 Receptor Antagonist-induced Memory Deficit in Rats. J Pharmacol Sci. 2010;113(1):41-7. PubMed PMID: 20424385.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ameliorative effect of a hippocampal metabotropic glutamate- receptor agonist on histamine H1 receptor antagonist-induced memory deficit in rats. AU - Masuoka,Takayoshi, AU - Mikami,Azusa, AU - Kamei,Chiaki, Y1 - 2010/04/16/ PY - 2010/4/29/entrez PY - 2010/4/29/pubmed PY - 2010/9/14/medline SP - 41 EP - 7 JF - Journal of pharmacological sciences JO - J Pharmacol Sci VL - 113 IS - 1 N2 - This study was performed to investigate the ameliorative effects of metabotropic glutamate (mGlu)-receptor agonists on histamine H(1) receptor antagonist-induced spatial memory deficit and the decrease in hippocampal theta activity in rats. Intraperitoneal injection of pyrilamine (35 mg/kg) resulted in impaired reference and working memory in the radial maze task and decreased hippocampal theta amplitude and power. The working memory deficit and decreased hippocampal theta power induced by pyrilamine were ameliorated by intrahippocampal injection of (RS)-3,5-dihydroxyphenylglycine (DHPG) (1 and 10 microg/side), a group I mGlu-receptor agonist; however, intrahippocampal injection of (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate (APDC), a group II mGlu-receptor agonist, and L-(+)-2-amino-4-phosphonobutyric acid (L-AP4), a group III mGlu-receptor agonist, showed no significant effect on the pyrilamine-induced memory deficit and decreased hippocampal theta activity. These results indicate that the activation of hippocampal group I mGlu receptors, but not group II and III mGlu receptors, improve the histamine H(1) receptor antagonist-induced working memory deficit and decreased hippocampal theta activity. SN - 1347-8648 UR - https://www.unboundmedicine.com/medline/citation/20424385/Ameliorative_effect_of_a_hippocampal_metabotropic_glutamate__receptor_agonist_on_histamine_H1_receptor_antagonist_induced_memory_deficit_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/JST.JSTAGE/jphs/10022FP DB - PRIME DP - Unbound Medicine ER -