Shah, Ankoor, and Robert T. Keenan. "Gout, Hyperuricemia, and the Risk of Cardiovascular Disease: Cause and Effect?" Current Rheumatology Reports, vol. 12, no. 2, 2010, pp. 118-24.
Shah A, Keenan RT. Gout, hyperuricemia, and the risk of cardiovascular disease: cause and effect? Curr Rheumatol Rep. 2010;12(2):118-24.
Shah, A., & Keenan, R. T. (2010). Gout, hyperuricemia, and the risk of cardiovascular disease: cause and effect? Current Rheumatology Reports, 12(2), 118-24. https://doi.org/10.1007/s11926-010-0084-3
Shah A, Keenan RT. Gout, Hyperuricemia, and the Risk of Cardiovascular Disease: Cause and Effect. Curr Rheumatol Rep. 2010;12(2):118-24. PubMed PMID: 20425020.
TY - JOUR
T1 - Gout, hyperuricemia, and the risk of cardiovascular disease: cause and effect?
AU - Shah,Ankoor,
AU - Keenan,Robert T,
PY - 2010/4/29/entrez
PY - 2010/4/29/pubmed
PY - 2010/7/23/medline
SP - 118
EP - 24
JF - Current rheumatology reports
JO - Curr Rheumatol Rep
VL - 12
IS - 2
N2 - Gout and hyperuricemia have long been suspected to be risk factors for cardiovascular disease. However, studies have frequently failed to distinguish whether these entities have an independent effect on cardiovascular risk or serve as markers for other risk factors. In vitro and animal studies suggest that uric acid is a biologically active compound that can increase inflammatory mediators known to lead to vascular damage. In contrast, uric acid also has potentially protective effects as a strong antioxidant, approaching the potency of vitamin C. Large clinical trials demonstrate a consistent relationship between elevated serum uric acid and a variety of cardiovascular diseases, although the strength of association varies greatly. We review the evidence for and against an independent role for hyperuricemia and/or gout in cardiovascular pathology.
SN - 1534-6307
UR - https://www.unboundmedicine.com/medline/citation/20425020/Gout_hyperuricemia_and_the_risk_of_cardiovascular_disease:_cause_and_effect
L2 - https://dx.doi.org/10.1007/s11926-010-0084-3
DB - PRIME
DP - Unbound Medicine