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Gout, hyperuricemia, and the risk of cardiovascular disease: cause and effect?
Curr Rheumatol Rep. 2010 Apr; 12(2):118-24.CR

Abstract

Gout and hyperuricemia have long been suspected to be risk factors for cardiovascular disease. However, studies have frequently failed to distinguish whether these entities have an independent effect on cardiovascular risk or serve as markers for other risk factors. In vitro and animal studies suggest that uric acid is a biologically active compound that can increase inflammatory mediators known to lead to vascular damage. In contrast, uric acid also has potentially protective effects as a strong antioxidant, approaching the potency of vitamin C. Large clinical trials demonstrate a consistent relationship between elevated serum uric acid and a variety of cardiovascular diseases, although the strength of association varies greatly. We review the evidence for and against an independent role for hyperuricemia and/or gout in cardiovascular pathology.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Shah A
Division of Rheumatology and Immunology, Duke University School of Medicine, 301 Trent Drive, Durham, NC 27710, USA.
Keenan RT
No affiliation info available

MeSH

AnimalsAntioxidantsCardiovascular DiseasesCells, CulturedClinical Trials as TopicComorbidityDisease Models, AnimalGoutHumansHyperuricemiaInflammation MediatorsMetabolic SyndromeRisk FactorsUric Acid

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20425020

Citation

Shah, Ankoor, and Robert T. Keenan. "Gout, Hyperuricemia, and the Risk of Cardiovascular Disease: Cause and Effect?" Current Rheumatology Reports, vol. 12, no. 2, 2010, pp. 118-24.
Shah A, Keenan RT. Gout, hyperuricemia, and the risk of cardiovascular disease: cause and effect? Curr Rheumatol Rep. 2010;12(2):118-24.
Shah, A., & Keenan, R. T. (2010). Gout, hyperuricemia, and the risk of cardiovascular disease: cause and effect? Current Rheumatology Reports, 12(2), 118-24. https://doi.org/10.1007/s11926-010-0084-3
Shah A, Keenan RT. Gout, Hyperuricemia, and the Risk of Cardiovascular Disease: Cause and Effect. Curr Rheumatol Rep. 2010;12(2):118-24. PubMed PMID: 20425020.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gout, hyperuricemia, and the risk of cardiovascular disease: cause and effect? AU - Shah,Ankoor, AU - Keenan,Robert T, PY - 2010/4/29/entrez PY - 2010/4/29/pubmed PY - 2010/7/23/medline SP - 118 EP - 24 JF - Current rheumatology reports JO - Curr Rheumatol Rep VL - 12 IS - 2 N2 - Gout and hyperuricemia have long been suspected to be risk factors for cardiovascular disease. However, studies have frequently failed to distinguish whether these entities have an independent effect on cardiovascular risk or serve as markers for other risk factors. In vitro and animal studies suggest that uric acid is a biologically active compound that can increase inflammatory mediators known to lead to vascular damage. In contrast, uric acid also has potentially protective effects as a strong antioxidant, approaching the potency of vitamin C. Large clinical trials demonstrate a consistent relationship between elevated serum uric acid and a variety of cardiovascular diseases, although the strength of association varies greatly. We review the evidence for and against an independent role for hyperuricemia and/or gout in cardiovascular pathology. SN - 1534-6307 UR - https://www.unboundmedicine.com/medline/citation/20425020/Gout_hyperuricemia_and_the_risk_of_cardiovascular_disease:_cause_and_effect L2 - https://dx.doi.org/10.1007/s11926-010-0084-3 DB - PRIME DP - Unbound Medicine ER -