Tags

Type your tag names separated by a space and hit enter

Management of the patient with statin intolerance.
Curr Atheroscler Rep. 2010 Jan; 12(1):48-57.CA

Abstract

Current guidelines recommend statins as first-line therapy for reducing low-density lipoprotein cholesterol (LDL-C) and preventing cardiovascular events. Patients taking statins frequently experience adverse effects during therapy. The first step is to determine whether the adverse effects are indeed related to statin therapy by statin dechallenge and rechallenge. Strategies for managing statin intolerance include changing statins, intermittent dosing, intensification of lifestyle modifications, and using other LDL-C-lowering agents such as ezetimibe, bile acid sequestrants, and LDL apheresis in suitable patients. More controversial approaches include red yeast rice, coenzyme Q10, and vitamin D supplementation. New therapies for LDL-C lowering are in development.

Authors+Show Affiliations

Division of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USA. byron-vandenberg@uiowa.eduNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20425271

Citation

Vandenberg, Byron F., and Jennifer Robinson. "Management of the Patient With Statin Intolerance." Current Atherosclerosis Reports, vol. 12, no. 1, 2010, pp. 48-57.
Vandenberg BF, Robinson J. Management of the patient with statin intolerance. Curr Atheroscler Rep. 2010;12(1):48-57.
Vandenberg, B. F., & Robinson, J. (2010). Management of the patient with statin intolerance. Current Atherosclerosis Reports, 12(1), 48-57. https://doi.org/10.1007/s11883-009-0077-8
Vandenberg BF, Robinson J. Management of the Patient With Statin Intolerance. Curr Atheroscler Rep. 2010;12(1):48-57. PubMed PMID: 20425271.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Management of the patient with statin intolerance. AU - Vandenberg,Byron F, AU - Robinson,Jennifer, PY - 2010/4/29/entrez PY - 2010/4/29/pubmed PY - 2010/10/6/medline SP - 48 EP - 57 JF - Current atherosclerosis reports JO - Curr Atheroscler Rep VL - 12 IS - 1 N2 - Current guidelines recommend statins as first-line therapy for reducing low-density lipoprotein cholesterol (LDL-C) and preventing cardiovascular events. Patients taking statins frequently experience adverse effects during therapy. The first step is to determine whether the adverse effects are indeed related to statin therapy by statin dechallenge and rechallenge. Strategies for managing statin intolerance include changing statins, intermittent dosing, intensification of lifestyle modifications, and using other LDL-C-lowering agents such as ezetimibe, bile acid sequestrants, and LDL apheresis in suitable patients. More controversial approaches include red yeast rice, coenzyme Q10, and vitamin D supplementation. New therapies for LDL-C lowering are in development. SN - 1534-6242 UR - https://www.unboundmedicine.com/medline/citation/20425271/Management_of_the_patient_with_statin_intolerance_ L2 - https://dx.doi.org/10.1007/s11883-009-0077-8 DB - PRIME DP - Unbound Medicine ER -