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Risks of overweight and abdominal obesity at age 16 years associated with prenatal exposures to maternal prepregnancy overweight and gestational diabetes mellitus.

Abstract

OBJECTIVE

The associations of prenatal exposures to maternal prepregnancy overweight and gestational diabetes mellitus (GDM) with offspring overweight are controversial. Research estimating risk for offspring overweight due to these exposures, separately and concomitantly, is limited.

RESEARCH DESIGN AND METHODS

Prevalence of overweight and abdominal obesity at age 16 years and odds ratios (ORs) for prenatal exposures to maternal prepregnancy overweight and GDM were estimated in participants of the prospective longitudinal Northern Finland Birth Cohort of 1986 (N = 4,168).

RESULTS

The prevalence and estimates of risk for overweight and abdominal obesity were highest in those exposed to both maternal prepregnancy overweight and GDM (overweight prevalence 40% [OR 4.05], abdominal obesity prevalence 25.7% [3.82]). Even in offspring of mothers with a normal oral glucose tolerance test during pregnancy, maternal prepregnancy overweight is associated with increased risk for these outcomes (overweight prevalence 27.9% [2.56], abdominal obesity prevalence 19.5% [2.60]). In offspring of women with prepregnancy normal weight, the prevalence or risks of the outcomes were not increased by prenatal exposure to GDM. These estimates of risk were adjusted for parental prepregnancy smoking, paternal overweight, and offspring sex and size at birth.

CONCLUSIONS

Maternal prepregnancy overweight is an independent risk factor for offspring overweight and abdominal obesity at age 16 years. The risks are highest in offspring with concomitant prenatal exposure to maternal prepregnancy overweight and GDM, whereas the risks associated with GDM are only small.

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  • Authors+Show Affiliations

    ,

    Department of Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland. jatta.pirkola@gmail.com

    , , , , ,

    Source

    Diabetes care 33:5 2010 May pg 1115-21

    MeSH

    Adolescent
    Adult
    Birth Weight
    Blood Glucose
    Diabetes, Gestational
    Fathers
    Female
    Finland
    Humans
    Infant, Newborn
    Longitudinal Studies
    Male
    Mothers
    Obesity, Abdominal
    Overweight
    Pregnancy
    Prenatal Exposure Delayed Effects
    Prevalence
    Risk Factors

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    20427685

    Citation

    Pirkola, Jatta, et al. "Risks of Overweight and Abdominal Obesity at Age 16 Years Associated With Prenatal Exposures to Maternal Prepregnancy Overweight and Gestational Diabetes Mellitus." Diabetes Care, vol. 33, no. 5, 2010, pp. 1115-21.
    Pirkola J, Pouta A, Bloigu A, et al. Risks of overweight and abdominal obesity at age 16 years associated with prenatal exposures to maternal prepregnancy overweight and gestational diabetes mellitus. Diabetes Care. 2010;33(5):1115-21.
    Pirkola, J., Pouta, A., Bloigu, A., Hartikainen, A. L., Laitinen, J., Järvelin, M. R., & Vääräsmäki, M. (2010). Risks of overweight and abdominal obesity at age 16 years associated with prenatal exposures to maternal prepregnancy overweight and gestational diabetes mellitus. Diabetes Care, 33(5), pp. 1115-21. doi:10.2337/dc09-1871.
    Pirkola J, et al. Risks of Overweight and Abdominal Obesity at Age 16 Years Associated With Prenatal Exposures to Maternal Prepregnancy Overweight and Gestational Diabetes Mellitus. Diabetes Care. 2010;33(5):1115-21. PubMed PMID: 20427685.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Risks of overweight and abdominal obesity at age 16 years associated with prenatal exposures to maternal prepregnancy overweight and gestational diabetes mellitus. AU - Pirkola,Jatta, AU - Pouta,Anneli, AU - Bloigu,Aini, AU - Hartikainen,Anna-Liisa, AU - Laitinen,Jaana, AU - Järvelin,Marjo-Riitta, AU - Vääräsmäki,Marja, PY - 2010/4/30/entrez PY - 2010/4/30/pubmed PY - 2010/7/22/medline SP - 1115 EP - 21 JF - Diabetes care JO - Diabetes Care VL - 33 IS - 5 N2 - OBJECTIVE: The associations of prenatal exposures to maternal prepregnancy overweight and gestational diabetes mellitus (GDM) with offspring overweight are controversial. Research estimating risk for offspring overweight due to these exposures, separately and concomitantly, is limited. RESEARCH DESIGN AND METHODS: Prevalence of overweight and abdominal obesity at age 16 years and odds ratios (ORs) for prenatal exposures to maternal prepregnancy overweight and GDM were estimated in participants of the prospective longitudinal Northern Finland Birth Cohort of 1986 (N = 4,168). RESULTS: The prevalence and estimates of risk for overweight and abdominal obesity were highest in those exposed to both maternal prepregnancy overweight and GDM (overweight prevalence 40% [OR 4.05], abdominal obesity prevalence 25.7% [3.82]). Even in offspring of mothers with a normal oral glucose tolerance test during pregnancy, maternal prepregnancy overweight is associated with increased risk for these outcomes (overweight prevalence 27.9% [2.56], abdominal obesity prevalence 19.5% [2.60]). In offspring of women with prepregnancy normal weight, the prevalence or risks of the outcomes were not increased by prenatal exposure to GDM. These estimates of risk were adjusted for parental prepregnancy smoking, paternal overweight, and offspring sex and size at birth. CONCLUSIONS: Maternal prepregnancy overweight is an independent risk factor for offspring overweight and abdominal obesity at age 16 years. The risks are highest in offspring with concomitant prenatal exposure to maternal prepregnancy overweight and GDM, whereas the risks associated with GDM are only small. SN - 1935-5548 UR - https://www.unboundmedicine.com/medline/citation/20427685/Risks_of_overweight_and_abdominal_obesity_at_age_16_years_associated_with_prenatal_exposures_to_maternal_prepregnancy_overweight_and_gestational_diabetes_mellitus_ L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&pmid=20427685 DB - PRIME DP - Unbound Medicine ER -