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Zinc decreases C-reactive protein, lipid peroxidation, and inflammatory cytokines in elderly subjects: a potential implication of zinc as an atheroprotective agent.
Am J Clin Nutr. 2010 Jun; 91(6):1634-41.AJ

Abstract

BACKGROUND

Chronic inflammation and oxidative stress are common risk factors for atherosclerosis. Zinc is an essential micronutrient that can function as an antiinflammatory and antioxidative agent, and as such, it may have atheroprotective properties.

OBJECTIVE

We hypothesized that zinc down-regulates the production of atherosclerosis-related cytokines/molecules in humans.

DESIGN

To examine these effects, we conducted a randomized, double-blinded, placebo trial of zinc supplementation in elderly subjects. We recruited 40 healthy elderly subjects (aged 56-83 y) and randomly assigned them to 2 groups. One group was given an oral dose of 45 mg zinc/d as a gluconate for 6 mo. The other group was given a placebo. Cell culture models were conducted to study the mechanism of zinc as an atheroprotective agent.

RESULTS

After 6 mo of supplementation, the intake of zinc, compared with intake of placebo, increased the concentrations of plasma zinc and decreased the concentrations of plasma high-sensitivity C-reactive protein (hsCRP), interleukin (IL)-6, macrophage chemoattractant protein 1 (MCP-1), vascular cell adhesion molecule 1 (VCAM-1), secretory phospholipase A2, and malondialdehyde and hydroxyalkenals (MDA+HAE) in elderly subjects. Regression analysis showed that changes in concentrations of plasma zinc were inversely associated with changes in concentrations of plasma hsCRP, MCP-1, VCAM-1, and MDA+HAE after 6 mo of supplementation. In cell culture studies, we showed that zinc decreased the generation of tumor necrosis factor-alpha, IL-1beta, VCAM-1, and MDA+HAE and the activation of nuclear transcription factor kappaB and increased antiinflammatory proteins A20 and peroxisome proliferator-activated receptor-alpha in human monocytic leukemia THP-1 cells and human aortic endothelial cells compared with zinc-deficient cells.

CONCLUSION

These findings suggest that zinc may have a protective effect in atherosclerosis because of its antiinflammatory and antioxidant functions.

Authors+Show Affiliations

Department of Internal Medicine, Wayne State University, Detroit, MI, USA. bbao@med.wayne.edu <bbao@med.wayne.edu>No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20427734

Citation

Bao, Bin, et al. "Zinc Decreases C-reactive Protein, Lipid Peroxidation, and Inflammatory Cytokines in Elderly Subjects: a Potential Implication of Zinc as an Atheroprotective Agent." The American Journal of Clinical Nutrition, vol. 91, no. 6, 2010, pp. 1634-41.
Bao B, Prasad AS, Beck FW, et al. Zinc decreases C-reactive protein, lipid peroxidation, and inflammatory cytokines in elderly subjects: a potential implication of zinc as an atheroprotective agent. Am J Clin Nutr. 2010;91(6):1634-41.
Bao, B., Prasad, A. S., Beck, F. W., Fitzgerald, J. T., Snell, D., Bao, G. W., Singh, T., & Cardozo, L. J. (2010). Zinc decreases C-reactive protein, lipid peroxidation, and inflammatory cytokines in elderly subjects: a potential implication of zinc as an atheroprotective agent. The American Journal of Clinical Nutrition, 91(6), 1634-41. https://doi.org/10.3945/ajcn.2009.28836
Bao B, et al. Zinc Decreases C-reactive Protein, Lipid Peroxidation, and Inflammatory Cytokines in Elderly Subjects: a Potential Implication of Zinc as an Atheroprotective Agent. Am J Clin Nutr. 2010;91(6):1634-41. PubMed PMID: 20427734.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Zinc decreases C-reactive protein, lipid peroxidation, and inflammatory cytokines in elderly subjects: a potential implication of zinc as an atheroprotective agent. AU - Bao,Bin, AU - Prasad,Ananda S, AU - Beck,Frances W J, AU - Fitzgerald,James T, AU - Snell,Diane, AU - Bao,Ginny W, AU - Singh,Tapinder, AU - Cardozo,Lavoisier J, Y1 - 2010/04/28/ PY - 2010/4/30/entrez PY - 2010/4/30/pubmed PY - 2010/6/11/medline SP - 1634 EP - 41 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 91 IS - 6 N2 - BACKGROUND: Chronic inflammation and oxidative stress are common risk factors for atherosclerosis. Zinc is an essential micronutrient that can function as an antiinflammatory and antioxidative agent, and as such, it may have atheroprotective properties. OBJECTIVE: We hypothesized that zinc down-regulates the production of atherosclerosis-related cytokines/molecules in humans. DESIGN: To examine these effects, we conducted a randomized, double-blinded, placebo trial of zinc supplementation in elderly subjects. We recruited 40 healthy elderly subjects (aged 56-83 y) and randomly assigned them to 2 groups. One group was given an oral dose of 45 mg zinc/d as a gluconate for 6 mo. The other group was given a placebo. Cell culture models were conducted to study the mechanism of zinc as an atheroprotective agent. RESULTS: After 6 mo of supplementation, the intake of zinc, compared with intake of placebo, increased the concentrations of plasma zinc and decreased the concentrations of plasma high-sensitivity C-reactive protein (hsCRP), interleukin (IL)-6, macrophage chemoattractant protein 1 (MCP-1), vascular cell adhesion molecule 1 (VCAM-1), secretory phospholipase A2, and malondialdehyde and hydroxyalkenals (MDA+HAE) in elderly subjects. Regression analysis showed that changes in concentrations of plasma zinc were inversely associated with changes in concentrations of plasma hsCRP, MCP-1, VCAM-1, and MDA+HAE after 6 mo of supplementation. In cell culture studies, we showed that zinc decreased the generation of tumor necrosis factor-alpha, IL-1beta, VCAM-1, and MDA+HAE and the activation of nuclear transcription factor kappaB and increased antiinflammatory proteins A20 and peroxisome proliferator-activated receptor-alpha in human monocytic leukemia THP-1 cells and human aortic endothelial cells compared with zinc-deficient cells. CONCLUSION: These findings suggest that zinc may have a protective effect in atherosclerosis because of its antiinflammatory and antioxidant functions. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/20427734/Zinc_decreases_C_reactive_protein_lipid_peroxidation_and_inflammatory_cytokines_in_elderly_subjects:_a_potential_implication_of_zinc_as_an_atheroprotective_agent_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.2009.28836 DB - PRIME DP - Unbound Medicine ER -