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Cannabidiol attenuates the appetitive effects of Delta 9-tetrahydrocannabinol in humans smoking their chosen cannabis.
Neuropsychopharmacology 2010; 35(9):1879-85N

Abstract

Worldwide cannabis dependence is increasing, as is the concentration of Delta(9)-tetrahydrocannabinol (THC) in street cannabis. At the same time, the concentration of the second most abundant cannabinoid in street cannabis, cannabidiol (CBD), is decreasing. These two cannabinoids have opposing effects both pharmacologically and behaviorally when administered in the laboratory. No research has yet examined how the ratio of these constituents impacts on the appetitive/reinforcing effects of cannabis in humans. A total of 94 cannabis users were tested 7 days apart, once while non-intoxicated and once while acutely under the influence of their own chosen smoked cannabis on dependence-related measures. Using an unprecedented methodology, a sample of cannabis (as well as saliva) was collected from each user and analyzed for levels of cannabinoids. On the basis of CBD : THC ratios in the cannabis, individuals from the top and bottom tertiles were directly compared on indices of the reinforcing effects of drugs, explicit liking, and implicit attentional bias to drug stimuli. When intoxicated, smokers of high CBD : THC strains showed reduced attentional bias to drug and food stimuli compared with smokers of low CBD : THC. Those smoking higher CBD : THC strains also showed lower self-rated liking of cannabis stimuli on both test days. Our findings suggest that CBD has potential as a treatment for cannabis dependence. The acute modulation of the incentive salience of drug cues by CBD may possibly generalize to a treatment for other addictive disorders.

Authors+Show Affiliations

Clinical Psychopharmacology Unit, Research Department of Clinical, Health and Educational Psychology, University College London, London, UK. c.morgan@ucl.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20428110

Citation

Morgan, Celia J A., et al. "Cannabidiol Attenuates the Appetitive Effects of Delta 9-tetrahydrocannabinol in Humans Smoking Their Chosen Cannabis." Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, vol. 35, no. 9, 2010, pp. 1879-85.
Morgan CJ, Freeman TP, Schafer GL, et al. Cannabidiol attenuates the appetitive effects of Delta 9-tetrahydrocannabinol in humans smoking their chosen cannabis. Neuropsychopharmacology. 2010;35(9):1879-85.
Morgan, C. J., Freeman, T. P., Schafer, G. L., & Curran, H. V. (2010). Cannabidiol attenuates the appetitive effects of Delta 9-tetrahydrocannabinol in humans smoking their chosen cannabis. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 35(9), pp. 1879-85. doi:10.1038/npp.2010.58.
Morgan CJ, et al. Cannabidiol Attenuates the Appetitive Effects of Delta 9-tetrahydrocannabinol in Humans Smoking Their Chosen Cannabis. Neuropsychopharmacology. 2010;35(9):1879-85. PubMed PMID: 20428110.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cannabidiol attenuates the appetitive effects of Delta 9-tetrahydrocannabinol in humans smoking their chosen cannabis. AU - Morgan,Celia J A, AU - Freeman,Tom P, AU - Schafer,Gráinne L, AU - Curran,H Valerie, Y1 - 2010/04/28/ PY - 2010/4/30/entrez PY - 2010/4/30/pubmed PY - 2010/10/29/medline SP - 1879 EP - 85 JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology JO - Neuropsychopharmacology VL - 35 IS - 9 N2 - Worldwide cannabis dependence is increasing, as is the concentration of Delta(9)-tetrahydrocannabinol (THC) in street cannabis. At the same time, the concentration of the second most abundant cannabinoid in street cannabis, cannabidiol (CBD), is decreasing. These two cannabinoids have opposing effects both pharmacologically and behaviorally when administered in the laboratory. No research has yet examined how the ratio of these constituents impacts on the appetitive/reinforcing effects of cannabis in humans. A total of 94 cannabis users were tested 7 days apart, once while non-intoxicated and once while acutely under the influence of their own chosen smoked cannabis on dependence-related measures. Using an unprecedented methodology, a sample of cannabis (as well as saliva) was collected from each user and analyzed for levels of cannabinoids. On the basis of CBD : THC ratios in the cannabis, individuals from the top and bottom tertiles were directly compared on indices of the reinforcing effects of drugs, explicit liking, and implicit attentional bias to drug stimuli. When intoxicated, smokers of high CBD : THC strains showed reduced attentional bias to drug and food stimuli compared with smokers of low CBD : THC. Those smoking higher CBD : THC strains also showed lower self-rated liking of cannabis stimuli on both test days. Our findings suggest that CBD has potential as a treatment for cannabis dependence. The acute modulation of the incentive salience of drug cues by CBD may possibly generalize to a treatment for other addictive disorders. SN - 1740-634X UR - https://www.unboundmedicine.com/medline/citation/20428110/Cannabidiol_attenuates_the_appetitive_effects_of_Delta_9_tetrahydrocannabinol_in_humans_smoking_their_chosen_cannabis_ L2 - http://dx.doi.org/10.1038/npp.2010.58 DB - PRIME DP - Unbound Medicine ER -