Tags

Type your tag names separated by a space and hit enter

A prospective study of maturity-onset diabetes mellitus and risk of coronary heart disease and stroke in women.
Arch Intern Med. 1991 Jun; 151(6):1141-7.AI

Abstract

We examined the relationship of maturity-onset clinical diabetes mellitus with the subsequent incidence of coronary heart disease, stroke, total cardiovascular mortality, and all-cause mortality in a cohort of 116,177 US women who were 30 to 55 years of age and free of known coronary heart disease, stroke, and cancer in 1976. During 8 years of follow-up (889 255 person-years), we identified 338 nonfatal myocardial infarctions, 111 coronary deaths, 259 strokes, 238 cardiovascular deaths, and 1349 deaths from all causes. Diabetes was associated with a markedly increased risk of nonfatal myocardial infarction and fatal coronary heart disease (age-adjusted relative risk [RR] = 6.7; 95% confidence interval [CI], 5.3 to 8.4), ischemic stroke (RR = 5.4; 95% CI, 3.3 to 9.0), total cardiovascular mortality (RR = 6.3; 95% CI, 4.6 to 8.6), and all-cause mortality (RR = 3.0; 95% CI, 2.5 to 3.7). A major independent effect of diabetes persisted in multivariate analyses after simultaneous control for other known coronary risk factors (for these end points, RR [95% CI] = 3.1 [2.3 to 4.2], 3.0 [1.6 to 5.7], 3.0 [1.9 to 4.8], and 1.9 [1.4 to 2.4], respectively). The absolute excess coronary risk due to diabetes was greater in the presence of other risk factors, including cigarette smoking, hypertension, and obesity. These prospective data indicate that maturity-onset clinical diabetes is a strong determinant of coronary heart disease, ischemic stroke, and cardiovascular mortality among middle-aged women. The adverse effect of diabetes is amplified in the presence of other cardiovascular risk factors, many of which are modifiable.

Authors+Show Affiliations

Channing Laboratory, Department of Medicine, Harvard Medical School, Boston, MA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2043016

Citation

Manson, J E., et al. "A Prospective Study of Maturity-onset Diabetes Mellitus and Risk of Coronary Heart Disease and Stroke in Women." Archives of Internal Medicine, vol. 151, no. 6, 1991, pp. 1141-7.
Manson JE, Colditz GA, Stampfer MJ, et al. A prospective study of maturity-onset diabetes mellitus and risk of coronary heart disease and stroke in women. Arch Intern Med. 1991;151(6):1141-7.
Manson, J. E., Colditz, G. A., Stampfer, M. J., Willett, W. C., Krolewski, A. S., Rosner, B., Arky, R. A., Speizer, F. E., & Hennekens, C. H. (1991). A prospective study of maturity-onset diabetes mellitus and risk of coronary heart disease and stroke in women. Archives of Internal Medicine, 151(6), 1141-7.
Manson JE, et al. A Prospective Study of Maturity-onset Diabetes Mellitus and Risk of Coronary Heart Disease and Stroke in Women. Arch Intern Med. 1991;151(6):1141-7. PubMed PMID: 2043016.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A prospective study of maturity-onset diabetes mellitus and risk of coronary heart disease and stroke in women. AU - Manson,J E, AU - Colditz,G A, AU - Stampfer,M J, AU - Willett,W C, AU - Krolewski,A S, AU - Rosner,B, AU - Arky,R A, AU - Speizer,F E, AU - Hennekens,C H, PY - 1991/6/1/pubmed PY - 1991/6/1/medline PY - 1991/6/1/entrez SP - 1141 EP - 7 JF - Archives of internal medicine JO - Arch. Intern. Med. VL - 151 IS - 6 N2 - We examined the relationship of maturity-onset clinical diabetes mellitus with the subsequent incidence of coronary heart disease, stroke, total cardiovascular mortality, and all-cause mortality in a cohort of 116,177 US women who were 30 to 55 years of age and free of known coronary heart disease, stroke, and cancer in 1976. During 8 years of follow-up (889 255 person-years), we identified 338 nonfatal myocardial infarctions, 111 coronary deaths, 259 strokes, 238 cardiovascular deaths, and 1349 deaths from all causes. Diabetes was associated with a markedly increased risk of nonfatal myocardial infarction and fatal coronary heart disease (age-adjusted relative risk [RR] = 6.7; 95% confidence interval [CI], 5.3 to 8.4), ischemic stroke (RR = 5.4; 95% CI, 3.3 to 9.0), total cardiovascular mortality (RR = 6.3; 95% CI, 4.6 to 8.6), and all-cause mortality (RR = 3.0; 95% CI, 2.5 to 3.7). A major independent effect of diabetes persisted in multivariate analyses after simultaneous control for other known coronary risk factors (for these end points, RR [95% CI] = 3.1 [2.3 to 4.2], 3.0 [1.6 to 5.7], 3.0 [1.9 to 4.8], and 1.9 [1.4 to 2.4], respectively). The absolute excess coronary risk due to diabetes was greater in the presence of other risk factors, including cigarette smoking, hypertension, and obesity. These prospective data indicate that maturity-onset clinical diabetes is a strong determinant of coronary heart disease, ischemic stroke, and cardiovascular mortality among middle-aged women. The adverse effect of diabetes is amplified in the presence of other cardiovascular risk factors, many of which are modifiable. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/2043016/A_prospective_study_of_maturity_onset_diabetes_mellitus_and_risk_of_coronary_heart_disease_and_stroke_in_women_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/vol/151/pg/1141 DB - PRIME DP - Unbound Medicine ER -