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Dietary isoflavone intake, polymorphisms in the CYP17, CYP19, 17beta-HSD1, and SHBG genes, and risk of breast cancer in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians.
Nutr Cancer. 2010; 62(4):466-75.NC

Abstract

We tested the hypothesis that polymorphisms in cytochrome P450c17alpha (CYP17), aromatase (CYP19), 17beta-hydroxysteroid dehydrogenase type I (17beta-HSD1) and sex hormone-binding globulin (SHBG) genes may modify the association between isoflavone intake and breast cancer risk. We conducted hospital-based, case-control studies in Nagano, Japan and Sao Paulo, Brazil. A total of 846 pairs (388 Japanese, 79 Japanese Brazilians, and 379 non-Japanese Brazilians) completed validated food frequency questionnaires. Four single nucleotide polymorphisms (SNPs) in CYP17 (rs743572), CYP19 (rs10046), 17beta-HSD1 (rs605059), and SHBG (rs6259) genes were genotyped. We found no association between the 4 SNPs and breast cancer risk. In combination analyses of isoflavone intake and SNPs, an inverse association between intake and risk was limited to women with at least one A allele of the rs605059 polymorphism for all 3 populations, albeit without statistical significance. For the rs6259 polymorphism, the inverse association was limited to postmenopausal Japanese with the GG genotype (odds ratio [OR] for highest vs. lowest tertile = 0.50, 95% confidence interval [CI] = 0.29-0.87; P for trend < 0.01), and to non-Japanese Brazilians with at least one A allele (OR for consumers vs. nonconsumer = 0.21, 95% CI = 0.06-0.77). We found no remarkable difference for the rs743572 and rs10046 polymorphisms. Our findings suggest that polymorphisms in the 17beta-HSD1 and SHBG genes may modify the association between isoflavone intake and breast cancer risk.

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    • Authors+Show Affiliations

    Iwasaki M
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 104-0045, Japan. moiwasak@ncc.go.jp
    Hamada GS
    No affiliation info available
    Nishimoto IN
    No affiliation info available
    Netto MM
    No affiliation info available
    Motola J
    No affiliation info available
    Laginha FM
    No affiliation info available
    Kasuga Y
    No affiliation info available
    Yokoyama S
    No affiliation info available
    Onuma H
    No affiliation info available
    Nishimura H
    No affiliation info available
    Kusama R
    No affiliation info available
    Kobayashi M
    No affiliation info available
    Ishihara J
    No affiliation info available
    Yamamoto S
    No affiliation info available
    Hanaoka T
    No affiliation info available
    Tsugane S
    No affiliation info available

    MeSH

    Aconitate HydrataseAdultAgedAromataseBrazilBreast NeoplasmsCase-Control StudiesDietEstradiol DehydrogenasesFemaleGene FrequencyGenetic Association StudiesGonadal Steroid HormonesHumansIsoflavonesJapanMiddle AgedPolymorphism, Single NucleotideRisk AssessmentSex Hormone-Binding GlobulinSteroid 17-alpha-HydroxylaseSteroid HydroxylasesSurveys and QuestionnairesYoung Adult

    Pub Type(s)

    Comparative Study
    Journal Article
    Multicenter Study
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    20432167

    Citation

    Iwasaki, Motoki, et al. "Dietary Isoflavone Intake, Polymorphisms in the CYP17, CYP19, 17beta-HSD1, and SHBG Genes, and Risk of Breast Cancer in Case-control Studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians." Nutrition and Cancer, vol. 62, no. 4, 2010, pp. 466-75.
    Iwasaki M, Hamada GS, Nishimoto IN, et al. Dietary isoflavone intake, polymorphisms in the CYP17, CYP19, 17beta-HSD1, and SHBG genes, and risk of breast cancer in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians. Nutr Cancer. 2010;62(4):466-75.
    Iwasaki, M., Hamada, G. S., Nishimoto, I. N., Netto, M. M., Motola, J., Laginha, F. M., Kasuga, Y., Yokoyama, S., Onuma, H., Nishimura, H., Kusama, R., Kobayashi, M., Ishihara, J., Yamamoto, S., Hanaoka, T., & Tsugane, S. (2010). Dietary isoflavone intake, polymorphisms in the CYP17, CYP19, 17beta-HSD1, and SHBG genes, and risk of breast cancer in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians. Nutrition and Cancer, 62(4), 466-75. https://doi.org/10.1080/01635580903441279
    Iwasaki M, et al. Dietary Isoflavone Intake, Polymorphisms in the CYP17, CYP19, 17beta-HSD1, and SHBG Genes, and Risk of Breast Cancer in Case-control Studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians. Nutr Cancer. 2010;62(4):466-75. PubMed PMID: 20432167.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary isoflavone intake, polymorphisms in the CYP17, CYP19, 17beta-HSD1, and SHBG genes, and risk of breast cancer in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians. AU - Iwasaki,Motoki, AU - Hamada,Gerson Shigeaki, AU - Nishimoto,Ines Nobuko, AU - Netto,Mario Mourão, AU - Motola,Juvenal,Jr AU - Laginha,Fábio Martins, AU - Kasuga,Yoshio, AU - Yokoyama,Shiro, AU - Onuma,Hiroshi, AU - Nishimura,Hideki, AU - Kusama,Ritsu, AU - Kobayashi,Minatsu, AU - Ishihara,Junko, AU - Yamamoto,Seiichiro, AU - Hanaoka,Tomoyuki, AU - Tsugane,Shoichiro, PY - 2010/5/1/entrez PY - 2010/5/1/pubmed PY - 2010/8/13/medline SP - 466 EP - 75 JF - Nutrition and cancer JO - Nutr Cancer VL - 62 IS - 4 N2 - We tested the hypothesis that polymorphisms in cytochrome P450c17alpha (CYP17), aromatase (CYP19), 17beta-hydroxysteroid dehydrogenase type I (17beta-HSD1) and sex hormone-binding globulin (SHBG) genes may modify the association between isoflavone intake and breast cancer risk. We conducted hospital-based, case-control studies in Nagano, Japan and Sao Paulo, Brazil. A total of 846 pairs (388 Japanese, 79 Japanese Brazilians, and 379 non-Japanese Brazilians) completed validated food frequency questionnaires. Four single nucleotide polymorphisms (SNPs) in CYP17 (rs743572), CYP19 (rs10046), 17beta-HSD1 (rs605059), and SHBG (rs6259) genes were genotyped. We found no association between the 4 SNPs and breast cancer risk. In combination analyses of isoflavone intake and SNPs, an inverse association between intake and risk was limited to women with at least one A allele of the rs605059 polymorphism for all 3 populations, albeit without statistical significance. For the rs6259 polymorphism, the inverse association was limited to postmenopausal Japanese with the GG genotype (odds ratio [OR] for highest vs. lowest tertile = 0.50, 95% confidence interval [CI] = 0.29-0.87; P for trend < 0.01), and to non-Japanese Brazilians with at least one A allele (OR for consumers vs. nonconsumer = 0.21, 95% CI = 0.06-0.77). We found no remarkable difference for the rs743572 and rs10046 polymorphisms. Our findings suggest that polymorphisms in the 17beta-HSD1 and SHBG genes may modify the association between isoflavone intake and breast cancer risk. SN - 1532-7914 UR - https://www.unboundmedicine.com/medline/citation/20432167/Dietary_isoflavone_intake_polymorphisms_in_the_CYP17_CYP19_17beta_HSD1_and_SHBG_genes_and_risk_of_breast_cancer_in_case_control_studies_in_Japanese_Japanese_Brazilians_and_non_Japanese_Brazilians_ L2 - http://www.tandfonline.com/doi/full/10.1080/01635580903441279 DB - PRIME DP - Unbound Medicine ER -