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Dietary isoflavone intake, polymorphisms in the CYP17, CYP19, 17beta-HSD1, and SHBG genes, and risk of breast cancer in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians.
Nutr Cancer. 2010; 62(4):466-75.NC

Abstract

We tested the hypothesis that polymorphisms in cytochrome P450c17alpha (CYP17), aromatase (CYP19), 17beta-hydroxysteroid dehydrogenase type I (17beta-HSD1) and sex hormone-binding globulin (SHBG) genes may modify the association between isoflavone intake and breast cancer risk. We conducted hospital-based, case-control studies in Nagano, Japan and Sao Paulo, Brazil. A total of 846 pairs (388 Japanese, 79 Japanese Brazilians, and 379 non-Japanese Brazilians) completed validated food frequency questionnaires. Four single nucleotide polymorphisms (SNPs) in CYP17 (rs743572), CYP19 (rs10046), 17beta-HSD1 (rs605059), and SHBG (rs6259) genes were genotyped. We found no association between the 4 SNPs and breast cancer risk. In combination analyses of isoflavone intake and SNPs, an inverse association between intake and risk was limited to women with at least one A allele of the rs605059 polymorphism for all 3 populations, albeit without statistical significance. For the rs6259 polymorphism, the inverse association was limited to postmenopausal Japanese with the GG genotype (odds ratio [OR] for highest vs. lowest tertile = 0.50, 95% confidence interval [CI] = 0.29-0.87; P for trend < 0.01), and to non-Japanese Brazilians with at least one A allele (OR for consumers vs. nonconsumer = 0.21, 95% CI = 0.06-0.77). We found no remarkable difference for the rs743572 and rs10046 polymorphisms. Our findings suggest that polymorphisms in the 17beta-HSD1 and SHBG genes may modify the association between isoflavone intake and breast cancer risk.

Authors+Show Affiliations

Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 104-0045, Japan. moiwasak@ncc.go.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20432167

Citation

Iwasaki, Motoki, et al. "Dietary Isoflavone Intake, Polymorphisms in the CYP17, CYP19, 17beta-HSD1, and SHBG Genes, and Risk of Breast Cancer in Case-control Studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians." Nutrition and Cancer, vol. 62, no. 4, 2010, pp. 466-75.
Iwasaki M, Hamada GS, Nishimoto IN, et al. Dietary isoflavone intake, polymorphisms in the CYP17, CYP19, 17beta-HSD1, and SHBG genes, and risk of breast cancer in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians. Nutr Cancer. 2010;62(4):466-75.
Iwasaki, M., Hamada, G. S., Nishimoto, I. N., Netto, M. M., Motola, J., Laginha, F. M., Kasuga, Y., Yokoyama, S., Onuma, H., Nishimura, H., Kusama, R., Kobayashi, M., Ishihara, J., Yamamoto, S., Hanaoka, T., & Tsugane, S. (2010). Dietary isoflavone intake, polymorphisms in the CYP17, CYP19, 17beta-HSD1, and SHBG genes, and risk of breast cancer in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians. Nutrition and Cancer, 62(4), 466-75. https://doi.org/10.1080/01635580903441279
Iwasaki M, et al. Dietary Isoflavone Intake, Polymorphisms in the CYP17, CYP19, 17beta-HSD1, and SHBG Genes, and Risk of Breast Cancer in Case-control Studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians. Nutr Cancer. 2010;62(4):466-75. PubMed PMID: 20432167.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary isoflavone intake, polymorphisms in the CYP17, CYP19, 17beta-HSD1, and SHBG genes, and risk of breast cancer in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians. AU - Iwasaki,Motoki, AU - Hamada,Gerson Shigeaki, AU - Nishimoto,Ines Nobuko, AU - Netto,Mario Mourão, AU - Motola,Juvenal,Jr AU - Laginha,Fábio Martins, AU - Kasuga,Yoshio, AU - Yokoyama,Shiro, AU - Onuma,Hiroshi, AU - Nishimura,Hideki, AU - Kusama,Ritsu, AU - Kobayashi,Minatsu, AU - Ishihara,Junko, AU - Yamamoto,Seiichiro, AU - Hanaoka,Tomoyuki, AU - Tsugane,Shoichiro, PY - 2010/5/1/entrez PY - 2010/5/1/pubmed PY - 2010/8/13/medline SP - 466 EP - 75 JF - Nutrition and cancer JO - Nutr Cancer VL - 62 IS - 4 N2 - We tested the hypothesis that polymorphisms in cytochrome P450c17alpha (CYP17), aromatase (CYP19), 17beta-hydroxysteroid dehydrogenase type I (17beta-HSD1) and sex hormone-binding globulin (SHBG) genes may modify the association between isoflavone intake and breast cancer risk. We conducted hospital-based, case-control studies in Nagano, Japan and Sao Paulo, Brazil. A total of 846 pairs (388 Japanese, 79 Japanese Brazilians, and 379 non-Japanese Brazilians) completed validated food frequency questionnaires. Four single nucleotide polymorphisms (SNPs) in CYP17 (rs743572), CYP19 (rs10046), 17beta-HSD1 (rs605059), and SHBG (rs6259) genes were genotyped. We found no association between the 4 SNPs and breast cancer risk. In combination analyses of isoflavone intake and SNPs, an inverse association between intake and risk was limited to women with at least one A allele of the rs605059 polymorphism for all 3 populations, albeit without statistical significance. For the rs6259 polymorphism, the inverse association was limited to postmenopausal Japanese with the GG genotype (odds ratio [OR] for highest vs. lowest tertile = 0.50, 95% confidence interval [CI] = 0.29-0.87; P for trend < 0.01), and to non-Japanese Brazilians with at least one A allele (OR for consumers vs. nonconsumer = 0.21, 95% CI = 0.06-0.77). We found no remarkable difference for the rs743572 and rs10046 polymorphisms. Our findings suggest that polymorphisms in the 17beta-HSD1 and SHBG genes may modify the association between isoflavone intake and breast cancer risk. SN - 1532-7914 UR - https://www.unboundmedicine.com/medline/citation/20432167/Dietary_isoflavone_intake_polymorphisms_in_the_CYP17_CYP19_17beta_HSD1_and_SHBG_genes_and_risk_of_breast_cancer_in_case_control_studies_in_Japanese_Japanese_Brazilians_and_non_Japanese_Brazilians_ L2 - http://www.tandfonline.com/doi/full/10.1080/01635580903441279 DB - PRIME DP - Unbound Medicine ER -