Citation
Iwasaki, Motoki, et al. "Dietary Isoflavone Intake, Polymorphisms in the CYP17, CYP19, 17beta-HSD1, and SHBG Genes, and Risk of Breast Cancer in Case-control Studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians." Nutrition and Cancer, vol. 62, no. 4, 2010, pp. 466-75.
Iwasaki M, Hamada GS, Nishimoto IN, et al. Dietary isoflavone intake, polymorphisms in the CYP17, CYP19, 17beta-HSD1, and SHBG genes, and risk of breast cancer in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians. Nutr Cancer. 2010;62(4):466-75.
Iwasaki, M., Hamada, G. S., Nishimoto, I. N., Netto, M. M., Motola, J., Laginha, F. M., Kasuga, Y., Yokoyama, S., Onuma, H., Nishimura, H., Kusama, R., Kobayashi, M., Ishihara, J., Yamamoto, S., Hanaoka, T., & Tsugane, S. (2010). Dietary isoflavone intake, polymorphisms in the CYP17, CYP19, 17beta-HSD1, and SHBG genes, and risk of breast cancer in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians. Nutrition and Cancer, 62(4), 466-75. https://doi.org/10.1080/01635580903441279
Iwasaki M, et al. Dietary Isoflavone Intake, Polymorphisms in the CYP17, CYP19, 17beta-HSD1, and SHBG Genes, and Risk of Breast Cancer in Case-control Studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians. Nutr Cancer. 2010;62(4):466-75. PubMed PMID: 20432167.
TY - JOUR
T1 - Dietary isoflavone intake, polymorphisms in the CYP17, CYP19, 17beta-HSD1, and SHBG genes, and risk of breast cancer in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians.
AU - Iwasaki,Motoki,
AU - Hamada,Gerson Shigeaki,
AU - Nishimoto,Ines Nobuko,
AU - Netto,Mario Mourão,
AU - Motola,Juvenal,Jr
AU - Laginha,Fábio Martins,
AU - Kasuga,Yoshio,
AU - Yokoyama,Shiro,
AU - Onuma,Hiroshi,
AU - Nishimura,Hideki,
AU - Kusama,Ritsu,
AU - Kobayashi,Minatsu,
AU - Ishihara,Junko,
AU - Yamamoto,Seiichiro,
AU - Hanaoka,Tomoyuki,
AU - Tsugane,Shoichiro,
PY - 2010/5/1/entrez
PY - 2010/5/1/pubmed
PY - 2010/8/13/medline
SP - 466
EP - 75
JF - Nutrition and cancer
JO - Nutr Cancer
VL - 62
IS - 4
N2 - We tested the hypothesis that polymorphisms in cytochrome P450c17alpha (CYP17), aromatase (CYP19), 17beta-hydroxysteroid dehydrogenase type I (17beta-HSD1) and sex hormone-binding globulin (SHBG) genes may modify the association between isoflavone intake and breast cancer risk. We conducted hospital-based, case-control studies in Nagano, Japan and Sao Paulo, Brazil. A total of 846 pairs (388 Japanese, 79 Japanese Brazilians, and 379 non-Japanese Brazilians) completed validated food frequency questionnaires. Four single nucleotide polymorphisms (SNPs) in CYP17 (rs743572), CYP19 (rs10046), 17beta-HSD1 (rs605059), and SHBG (rs6259) genes were genotyped. We found no association between the 4 SNPs and breast cancer risk. In combination analyses of isoflavone intake and SNPs, an inverse association between intake and risk was limited to women with at least one A allele of the rs605059 polymorphism for all 3 populations, albeit without statistical significance. For the rs6259 polymorphism, the inverse association was limited to postmenopausal Japanese with the GG genotype (odds ratio [OR] for highest vs. lowest tertile = 0.50, 95% confidence interval [CI] = 0.29-0.87; P for trend < 0.01), and to non-Japanese Brazilians with at least one A allele (OR for consumers vs. nonconsumer = 0.21, 95% CI = 0.06-0.77). We found no remarkable difference for the rs743572 and rs10046 polymorphisms. Our findings suggest that polymorphisms in the 17beta-HSD1 and SHBG genes may modify the association between isoflavone intake and breast cancer risk.
SN - 1532-7914
UR - https://www.unboundmedicine.com/medline/citation/20432167/Dietary_isoflavone_intake_polymorphisms_in_the_CYP17_CYP19_17beta_HSD1_and_SHBG_genes_and_risk_of_breast_cancer_in_case_control_studies_in_Japanese_Japanese_Brazilians_and_non_Japanese_Brazilians_
L2 - http://www.tandfonline.com/doi/full/10.1080/01635580903441279
DB - PRIME
DP - Unbound Medicine
ER -
