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Insulin and blood pressure regulation.
J Intern Med Suppl 1991; 735:49-64JI

Abstract

Epidemiological evidence suggests that there is a close association between obesity, non-insulin-dependent diabetes (NIDDM) and hypertension. Obesity and NIDDM are the classical insulin-resistant states. Even in the absence of these conditions, essential hypertension is associated with insulin resistance. In view of the acute effects of insulin on renal sodium reabsorption, the sympathetic nervous system, the renin-angiotensin-aldosterone system, the transmembranous cation transport, the cardiovascular reactivity, the atrial natriuretic peptide and the kallikrein-kinin system, hyperinsulinaemia may contribute to the development of hypertension in these diseases. Preliminary evidence suggests that sensitivity to these possible blood-pressure-elevating action(s) of insulin is still present despite the resistance to the glucose-lowering action of the hormone. However, extrapolation of the epidemiological data and results of acute experiments indicate that the impact on blood pressure is rather small. The pathophysiological mechanisms of hypertension in the above-mentioned conditions are also not always consistent with insulin action(s). Moreover, some data suggest that insulin resistance, and not hyperinsulinaemia per se, underlies the blood pressure elevation, while the possibility cannot be excluded that both hypertension and insulin resistance are co-inherited, but unrelated, abnormalities.

Authors+Show Affiliations

Department of Medicine, Free University Hospital, Amsterdam, The Netherlands.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

2043223

Citation

Gans, R O., and A J. Donker. "Insulin and Blood Pressure Regulation." Journal of Internal Medicine. Supplement, vol. 735, 1991, pp. 49-64.
Gans RO, Donker AJ. Insulin and blood pressure regulation. J Intern Med Suppl. 1991;735:49-64.
Gans, R. O., & Donker, A. J. (1991). Insulin and blood pressure regulation. Journal of Internal Medicine. Supplement, 735, pp. 49-64.
Gans RO, Donker AJ. Insulin and Blood Pressure Regulation. J Intern Med Suppl. 1991;735:49-64. PubMed PMID: 2043223.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Insulin and blood pressure regulation. AU - Gans,R O, AU - Donker,A J, PY - 1991/1/1/pubmed PY - 1991/1/1/medline PY - 1991/1/1/entrez SP - 49 EP - 64 JF - Journal of internal medicine. Supplement JO - J Intern Med Suppl VL - 735 N2 - Epidemiological evidence suggests that there is a close association between obesity, non-insulin-dependent diabetes (NIDDM) and hypertension. Obesity and NIDDM are the classical insulin-resistant states. Even in the absence of these conditions, essential hypertension is associated with insulin resistance. In view of the acute effects of insulin on renal sodium reabsorption, the sympathetic nervous system, the renin-angiotensin-aldosterone system, the transmembranous cation transport, the cardiovascular reactivity, the atrial natriuretic peptide and the kallikrein-kinin system, hyperinsulinaemia may contribute to the development of hypertension in these diseases. Preliminary evidence suggests that sensitivity to these possible blood-pressure-elevating action(s) of insulin is still present despite the resistance to the glucose-lowering action of the hormone. However, extrapolation of the epidemiological data and results of acute experiments indicate that the impact on blood pressure is rather small. The pathophysiological mechanisms of hypertension in the above-mentioned conditions are also not always consistent with insulin action(s). Moreover, some data suggest that insulin resistance, and not hyperinsulinaemia per se, underlies the blood pressure elevation, while the possibility cannot be excluded that both hypertension and insulin resistance are co-inherited, but unrelated, abnormalities. SN - 0955-7873 UR - https://www.unboundmedicine.com/medline/citation/2043223/Insulin_and_blood_pressure_regulation_ L2 - https://medlineplus.gov/diabetesmedicines.html DB - PRIME DP - Unbound Medicine ER -