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Anodic voltammetry of zolmitriptan at boron-doped diamond electrode and its analytical applications.
Pharmazie. 2010 Apr; 65(4):245-50.P

Abstract

The electrooxidative behavior and determination of zolmitriptan at a boron-doped diamond electrode were investigated using cyclic, linear sweep, differential pulse and square wave voltammetric techniques. Zolmitriptan undergoes irreversible oxidation at a peak potential of about +0.9 V (vs Ag/AgCl/3 M KCl). DPV and SWV techniques are proposed for the determination of zolmitriptan in phosphate buffer at pH 3.03, which allows quantitation over the two different ranges (8 x 10(-7) - 8 x 10(-6) M and 1 x 10(-5) - 1 x 10(-4) M) in supporting electrolyte for both methods. A linear response was obtained in phosphate buffer over two different ranges (6 x 10(-7) - 8 x 10(-6) M and 1 x 10(-5) - 1 x 10(-4) M) for spiked serum samples at pH 3.03 for both techniques. The repeatability and reproducibility of the methods for all media were determined. The standard addition method was used in serum. Precision and accuracy were also checked in all media. No electroactive interferences from the excipients and endegenous substances were found in the pharmaceutical dosage form and the biological sample, respectively.

Authors+Show Affiliations

Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry, Tandogan, Ankara, Turkey. buslu@pharmacy.ankara.edu.trNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20432618

Citation

Uslu, B, and D Canbaz. "Anodic Voltammetry of Zolmitriptan at Boron-doped Diamond Electrode and Its Analytical Applications." Die Pharmazie, vol. 65, no. 4, 2010, pp. 245-50.
Uslu B, Canbaz D. Anodic voltammetry of zolmitriptan at boron-doped diamond electrode and its analytical applications. Pharmazie. 2010;65(4):245-50.
Uslu, B., & Canbaz, D. (2010). Anodic voltammetry of zolmitriptan at boron-doped diamond electrode and its analytical applications. Die Pharmazie, 65(4), 245-50.
Uslu B, Canbaz D. Anodic Voltammetry of Zolmitriptan at Boron-doped Diamond Electrode and Its Analytical Applications. Pharmazie. 2010;65(4):245-50. PubMed PMID: 20432618.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anodic voltammetry of zolmitriptan at boron-doped diamond electrode and its analytical applications. AU - Uslu,B, AU - Canbaz,D, PY - 2010/5/4/entrez PY - 2010/5/4/pubmed PY - 2010/5/27/medline SP - 245 EP - 50 JF - Die Pharmazie JO - Pharmazie VL - 65 IS - 4 N2 - The electrooxidative behavior and determination of zolmitriptan at a boron-doped diamond electrode were investigated using cyclic, linear sweep, differential pulse and square wave voltammetric techniques. Zolmitriptan undergoes irreversible oxidation at a peak potential of about +0.9 V (vs Ag/AgCl/3 M KCl). DPV and SWV techniques are proposed for the determination of zolmitriptan in phosphate buffer at pH 3.03, which allows quantitation over the two different ranges (8 x 10(-7) - 8 x 10(-6) M and 1 x 10(-5) - 1 x 10(-4) M) in supporting electrolyte for both methods. A linear response was obtained in phosphate buffer over two different ranges (6 x 10(-7) - 8 x 10(-6) M and 1 x 10(-5) - 1 x 10(-4) M) for spiked serum samples at pH 3.03 for both techniques. The repeatability and reproducibility of the methods for all media were determined. The standard addition method was used in serum. Precision and accuracy were also checked in all media. No electroactive interferences from the excipients and endegenous substances were found in the pharmaceutical dosage form and the biological sample, respectively. SN - 0031-7144 UR - https://www.unboundmedicine.com/medline/citation/20432618/Anodic_voltammetry_of_zolmitriptan_at_boron_doped_diamond_electrode_and_its_analytical_applications_ DB - PRIME DP - Unbound Medicine ER -