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[Primary studies on chemical constituents from butanol extraction of the thorny elaeagnus leaf and their cytotoxicity].
Zhong Yao Cai. 2009 Dec; 32(12):1848-50.ZY

Abstract

OBJECTIVE

To study the chemical constituents and test the cytotoxicity of the purified compounds from the Thorny Elaeagnus Leaf.

METHODS

The constituents were isolated by column chromatography and their structures were elucidated by chemical properties and spectroscopic analysis. The cytotoxicity of the chemical components for SGC-7901 and Hela cells was measured by MuT method.

RESULTS

Four components were isolated and identified as 3'-O-methylquercetin(1),kaempferol-3-O-beta-D-6-O-(p-hydroxycinnamoyl) -glucopyranoside(2), kakkalide(3),3'-O-methyl-ellagic acid-4-O-alpha-L-rhamnicoside(4). These components had cytotoxicity for SGC-7901 and Hela cells.

CONCLUSION

Compounds 1,3 and 4 are isolated from Thorny Elaeagnus Leaf for the first time. The results of pharmacological experiments indicate that compounds 1 and 2 show strong cytotoxicity to Hela cells.

Authors+Show Affiliations

Institute of Materia Medica of Shandong Academy of Medical Sciences, Key Laboratory for Modern Medicine and Technology of Shan-dong Province, Jinan 250062, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

20432901

Citation

Fu, Yi-cheng, et al. "[Primary Studies On Chemical Constituents From Butanol Extraction of the Thorny Elaeagnus Leaf and Their Cytotoxicity]." Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal Materials, vol. 32, no. 12, 2009, pp. 1848-50.
Fu YC, Wang XJ, Jia XH, et al. [Primary studies on chemical constituents from butanol extraction of the thorny elaeagnus leaf and their cytotoxicity]. Zhong Yao Cai. 2009;32(12):1848-50.
Fu, Y. C., Wang, X. J., Jia, X. H., & Zhou, L. (2009). [Primary studies on chemical constituents from butanol extraction of the thorny elaeagnus leaf and their cytotoxicity]. Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal Materials, 32(12), 1848-50.
Fu YC, et al. [Primary Studies On Chemical Constituents From Butanol Extraction of the Thorny Elaeagnus Leaf and Their Cytotoxicity]. Zhong Yao Cai. 2009;32(12):1848-50. PubMed PMID: 20432901.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Primary studies on chemical constituents from butanol extraction of the thorny elaeagnus leaf and their cytotoxicity]. AU - Fu,Yi-cheng, AU - Wang,Xiao-jing, AU - Jia,Xian-hui, AU - Zhou,Ling, PY - 2010/5/4/entrez PY - 2010/5/4/pubmed PY - 2011/5/17/medline SP - 1848 EP - 50 JF - Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials JO - Zhong Yao Cai VL - 32 IS - 12 N2 - OBJECTIVE: To study the chemical constituents and test the cytotoxicity of the purified compounds from the Thorny Elaeagnus Leaf. METHODS: The constituents were isolated by column chromatography and their structures were elucidated by chemical properties and spectroscopic analysis. The cytotoxicity of the chemical components for SGC-7901 and Hela cells was measured by MuT method. RESULTS: Four components were isolated and identified as 3'-O-methylquercetin(1),kaempferol-3-O-beta-D-6-O-(p-hydroxycinnamoyl) -glucopyranoside(2), kakkalide(3),3'-O-methyl-ellagic acid-4-O-alpha-L-rhamnicoside(4). These components had cytotoxicity for SGC-7901 and Hela cells. CONCLUSION: Compounds 1,3 and 4 are isolated from Thorny Elaeagnus Leaf for the first time. The results of pharmacological experiments indicate that compounds 1 and 2 show strong cytotoxicity to Hela cells. SN - 1001-4454 UR - https://www.unboundmedicine.com/medline/citation/20432901/[Primary_studies_on_chemical_constituents_from_butanol_extraction_of_the_thorny_elaeagnus_leaf_and_their_cytotoxicity]_ DB - PRIME DP - Unbound Medicine ER -