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Unravelling the nature of postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: the role of elastase, complement C4a and interleukin-1beta.
J Intern Med. 2010 Apr; 267(4):418-35.JI

Abstract

OBJECTIVES

Too vigorous exercise or activity increase frequently triggers postexertional malaise in people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), a primary characteristic evident in up to 95% of people with ME/CFS. The present study aimed at examining whether two different types of exercise results in changes in health status, circulating elastase activity, interleukin (IL)-1beta and complement C4a levels.

DESIGN

Comparative experimental design.

SETTING

University.

SUBJECTS

Twenty-two women with ME/CFS and 22 healthy sedentary controls

INTERVENTIONS

participants were subjected to a submaximal exercise (day 8) and a self-paced, physiologically limited exercise (day 16). Each bout of exercise was preceded and followed by blood sampling, actigraphy and assessment of their health status.

RESULTS

Both submaximal exercise and self-paced, physiologically limited exercise resulted in postexertional malaise in people with ME/CFS. However, neither exercise bout altered elastase activity, IL-1beta or complement C4a split product levels in people with ME/CFS or healthy sedentary control subjects (P > 0.05). Postexercise complement C4a level was identified as a clinically important biomarker for postexertional malaise in people with ME/CFS.

CONCLUSIONS

Submaximal exercise as well as self-paced, physiologically limited exercise triggers postexertional malaise in people with ME/CFS, but neither types of exercise alter acute circulating levels of IL-1beta, complement C4a split product or elastase activity. Further studying of immune alterations in relation to postexertional malaise in people with ME/CFS using multiple measurement points postexercise is required.

Authors+Show Affiliations

Department of Human Physiology, Faculty of Physical Education & Physiotherapy, Vrije Universiteit Brussel, Brussels, Belgium. jo.nijs@vub.ac.beNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20433584

Citation

Nijs, J, et al. "Unravelling the Nature of Postexertional Malaise in Myalgic Encephalomyelitis/chronic Fatigue Syndrome: the Role of Elastase, Complement C4a and Interleukin-1beta." Journal of Internal Medicine, vol. 267, no. 4, 2010, pp. 418-35.
Nijs J, Van Oosterwijck J, Meeus M, et al. Unravelling the nature of postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: the role of elastase, complement C4a and interleukin-1beta. J Intern Med. 2010;267(4):418-35.
Nijs, J., Van Oosterwijck, J., Meeus, M., Lambrecht, L., Metzger, K., Frémont, M., & Paul, L. (2010). Unravelling the nature of postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: the role of elastase, complement C4a and interleukin-1beta. Journal of Internal Medicine, 267(4), 418-35. https://doi.org/10.1111/j.1365-2796.2009.02178.x
Nijs J, et al. Unravelling the Nature of Postexertional Malaise in Myalgic Encephalomyelitis/chronic Fatigue Syndrome: the Role of Elastase, Complement C4a and Interleukin-1beta. J Intern Med. 2010;267(4):418-35. PubMed PMID: 20433584.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Unravelling the nature of postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: the role of elastase, complement C4a and interleukin-1beta. AU - Nijs,J, AU - Van Oosterwijck,J, AU - Meeus,M, AU - Lambrecht,L, AU - Metzger,K, AU - Frémont,M, AU - Paul,L, PY - 2010/5/4/entrez PY - 2010/5/4/pubmed PY - 2010/6/15/medline SP - 418 EP - 35 JF - Journal of internal medicine JO - J Intern Med VL - 267 IS - 4 N2 - OBJECTIVES: Too vigorous exercise or activity increase frequently triggers postexertional malaise in people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), a primary characteristic evident in up to 95% of people with ME/CFS. The present study aimed at examining whether two different types of exercise results in changes in health status, circulating elastase activity, interleukin (IL)-1beta and complement C4a levels. DESIGN: Comparative experimental design. SETTING: University. SUBJECTS: Twenty-two women with ME/CFS and 22 healthy sedentary controls INTERVENTIONS: participants were subjected to a submaximal exercise (day 8) and a self-paced, physiologically limited exercise (day 16). Each bout of exercise was preceded and followed by blood sampling, actigraphy and assessment of their health status. RESULTS: Both submaximal exercise and self-paced, physiologically limited exercise resulted in postexertional malaise in people with ME/CFS. However, neither exercise bout altered elastase activity, IL-1beta or complement C4a split product levels in people with ME/CFS or healthy sedentary control subjects (P > 0.05). Postexercise complement C4a level was identified as a clinically important biomarker for postexertional malaise in people with ME/CFS. CONCLUSIONS: Submaximal exercise as well as self-paced, physiologically limited exercise triggers postexertional malaise in people with ME/CFS, but neither types of exercise alter acute circulating levels of IL-1beta, complement C4a split product or elastase activity. Further studying of immune alterations in relation to postexertional malaise in people with ME/CFS using multiple measurement points postexercise is required. SN - 1365-2796 UR - https://www.unboundmedicine.com/medline/citation/20433584/Unravelling_the_nature_of_postexertional_malaise_in_myalgic_encephalomyelitis/chronic_fatigue_syndrome:_the_role_of_elastase_complement_C4a_and_interleukin_1beta_ L2 - https://doi.org/10.1111/j.1365-2796.2009.02178.x DB - PRIME DP - Unbound Medicine ER -