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Lipoic acid effects on monoaminergic system after pilocarpine-induced seizures.
Neurosci Lett. 2010 Jun 25; 477(3):129-33.NL

Abstract

Systemic injection of pilocarpine has been shown to induce recurrent seizures and epileptic discharges demonstrated by EEG monitoring. It also has been reported that antioxidants are able to diminish or prevent the occurrence of epileptic discharges induced by pilocarpine through the inhibition of free radical formation and neurotransmitter metabolic alterations. The purpose of this work was to determine the effects of lipoic acid (LA) on the levels of dopamine (DA), serotonin (5-HT), norepinephrine (NE) and subsequent metabolites in the hippocampus of rats after seizure induction by pilocarpine. Seizures dramatically decreased the levels of DA, 5-hydroxyindoleacetic acid (5-HIAA) and NE, whereas significantly increased the levels of neurotransmitter metabolites. The administration of lipoic acid before seizure induction resulted in normalized levels of DA and 5-HA. However, the lipoic acid administration in similar conditions produced a reduction of the metabolites levels when compared with the pilocarpine group. These results suggest that the establishment of acute phase of seizures induced by pilocarpine might be produced by consequent the activation of serotonergic neurons. In addition, the lipoic acid inhibits hyperactivity of this system during the installation of pilocarpine-induced seizures.

Authors+Show Affiliations

Laboratory of Physiology and Pharmacology of Federal University of Piauí, Picos, Piauí, Brazil. rivelilson@pq.cnpq.brNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20433896

Citation

Freitas, R M., et al. "Lipoic Acid Effects On Monoaminergic System After Pilocarpine-induced Seizures." Neuroscience Letters, vol. 477, no. 3, 2010, pp. 129-33.
Freitas RM, Jordán J, Feng D. Lipoic acid effects on monoaminergic system after pilocarpine-induced seizures. Neurosci Lett. 2010;477(3):129-33.
Freitas, R. M., Jordán, J., & Feng, D. (2010). Lipoic acid effects on monoaminergic system after pilocarpine-induced seizures. Neuroscience Letters, 477(3), 129-33. https://doi.org/10.1016/j.neulet.2010.04.048
Freitas RM, Jordán J, Feng D. Lipoic Acid Effects On Monoaminergic System After Pilocarpine-induced Seizures. Neurosci Lett. 2010 Jun 25;477(3):129-33. PubMed PMID: 20433896.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lipoic acid effects on monoaminergic system after pilocarpine-induced seizures. AU - Freitas,R M, AU - Jordán,J, AU - Feng,D, Y1 - 2010/04/28/ PY - 2010/03/15/received PY - 2010/04/20/revised PY - 2010/04/20/accepted PY - 2010/5/4/entrez PY - 2010/5/4/pubmed PY - 2010/8/21/medline SP - 129 EP - 33 JF - Neuroscience letters JO - Neurosci Lett VL - 477 IS - 3 N2 - Systemic injection of pilocarpine has been shown to induce recurrent seizures and epileptic discharges demonstrated by EEG monitoring. It also has been reported that antioxidants are able to diminish or prevent the occurrence of epileptic discharges induced by pilocarpine through the inhibition of free radical formation and neurotransmitter metabolic alterations. The purpose of this work was to determine the effects of lipoic acid (LA) on the levels of dopamine (DA), serotonin (5-HT), norepinephrine (NE) and subsequent metabolites in the hippocampus of rats after seizure induction by pilocarpine. Seizures dramatically decreased the levels of DA, 5-hydroxyindoleacetic acid (5-HIAA) and NE, whereas significantly increased the levels of neurotransmitter metabolites. The administration of lipoic acid before seizure induction resulted in normalized levels of DA and 5-HA. However, the lipoic acid administration in similar conditions produced a reduction of the metabolites levels when compared with the pilocarpine group. These results suggest that the establishment of acute phase of seizures induced by pilocarpine might be produced by consequent the activation of serotonergic neurons. In addition, the lipoic acid inhibits hyperactivity of this system during the installation of pilocarpine-induced seizures. SN - 1872-7972 UR - https://www.unboundmedicine.com/medline/citation/20433896/Lipoic_acid_effects_on_monoaminergic_system_after_pilocarpine_induced_seizures_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(10)00509-4 DB - PRIME DP - Unbound Medicine ER -