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Is two better than one? A cross-modal oddball paradigm reveals greater sensitivity of the P300 to emotional face-voice associations.
Clin Neurophysiol. 2010 Nov; 121(11):1855-62.CN

Abstract

OBJECTIVE

Studies exploring neurophysiological correlates of main psychiatric disorders have commonly used event-related potentials (ERP) during a visual or an auditory oddball task. The main results concern modulations of the P3b amplitude and/or latency. The present study aims to increase the clinical sensitivity of these P3b modulations by using a more ecological oddball design, using synchronized pairs of audio-visual emotional stimuli.

METHOD

Two groups of healthy participants, one composed of controls and the other of students displaying anxious and depressive tendencies completed visual, auditory and audio-visual (cross-modal) oddball tasks, in which they had to detect deviant happy and sad stimuli among neutral ones as quickly as possible. Behavioral performance and P3b ERP data were analyzed.

RESULTS

Subjects displaying anxious and depressive tendencies exhibited lower P3b amplitude than the controls, but only in the cross-modal oddball task.

CONCLUSIONS

Although the two groups of subjects differed in their levels of co-morbid anxiety and depression, unimodal visual and auditory oddball tasks did not allow us to detect this difference by P3b amplitude modulations, but the cross-modal task did.

SIGNIFICANCE

These results suggest that a cross-modal oddball design should be used in future studies to increase the sensitivity of the P300 amplitude differences between healthy participants and those with clinical symptoms.

Authors+Show Affiliations

Laboratory of Psychological Medicine, Free University of Brussels, Brussels, Belgium. salvatore.campanella@chu-brugmann.beNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20434394

Citation

Campanella, Salvatore, et al. "Is Two Better Than One? a Cross-modal Oddball Paradigm Reveals Greater Sensitivity of the P300 to Emotional Face-voice Associations." Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, vol. 121, no. 11, 2010, pp. 1855-62.
Campanella S, Bruyer R, Froidbise S, et al. Is two better than one? A cross-modal oddball paradigm reveals greater sensitivity of the P300 to emotional face-voice associations. Clin Neurophysiol. 2010;121(11):1855-62.
Campanella, S., Bruyer, R., Froidbise, S., Rossignol, M., Joassin, F., Kornreich, C., Noël, X., & Verbanck, P. (2010). Is two better than one? A cross-modal oddball paradigm reveals greater sensitivity of the P300 to emotional face-voice associations. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, 121(11), 1855-62. https://doi.org/10.1016/j.clinph.2010.04.004
Campanella S, et al. Is Two Better Than One? a Cross-modal Oddball Paradigm Reveals Greater Sensitivity of the P300 to Emotional Face-voice Associations. Clin Neurophysiol. 2010;121(11):1855-62. PubMed PMID: 20434394.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is two better than one? A cross-modal oddball paradigm reveals greater sensitivity of the P300 to emotional face-voice associations. AU - Campanella,Salvatore, AU - Bruyer,Raymond, AU - Froidbise,Sophie, AU - Rossignol,Mandy, AU - Joassin,Frédéric, AU - Kornreich,Charles, AU - Noël,Xavier, AU - Verbanck,Paul, PY - 2009/12/04/received PY - 2010/03/26/revised PY - 2010/04/06/accepted PY - 2010/5/4/entrez PY - 2010/5/4/pubmed PY - 2010/10/15/medline SP - 1855 EP - 62 JF - Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology JO - Clin Neurophysiol VL - 121 IS - 11 N2 - OBJECTIVE: Studies exploring neurophysiological correlates of main psychiatric disorders have commonly used event-related potentials (ERP) during a visual or an auditory oddball task. The main results concern modulations of the P3b amplitude and/or latency. The present study aims to increase the clinical sensitivity of these P3b modulations by using a more ecological oddball design, using synchronized pairs of audio-visual emotional stimuli. METHOD: Two groups of healthy participants, one composed of controls and the other of students displaying anxious and depressive tendencies completed visual, auditory and audio-visual (cross-modal) oddball tasks, in which they had to detect deviant happy and sad stimuli among neutral ones as quickly as possible. Behavioral performance and P3b ERP data were analyzed. RESULTS: Subjects displaying anxious and depressive tendencies exhibited lower P3b amplitude than the controls, but only in the cross-modal oddball task. CONCLUSIONS: Although the two groups of subjects differed in their levels of co-morbid anxiety and depression, unimodal visual and auditory oddball tasks did not allow us to detect this difference by P3b amplitude modulations, but the cross-modal task did. SIGNIFICANCE: These results suggest that a cross-modal oddball design should be used in future studies to increase the sensitivity of the P300 amplitude differences between healthy participants and those with clinical symptoms. SN - 1872-8952 UR - https://www.unboundmedicine.com/medline/citation/20434394/Is_two_better_than_one_A_cross_modal_oddball_paradigm_reveals_greater_sensitivity_of_the_P300_to_emotional_face_voice_associations_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1388-2457(10)00355-X DB - PRIME DP - Unbound Medicine ER -