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Endoplasmic reticulum stress contributes to vitamin E succinate-induced apoptosis in human gastric cancer SGC-7901 cells.
Cancer Lett. 2010 Oct 01; 296(1):123-31.CL

Abstract

Vitamin E succinate (RRR-alpha-tocopheryl succinate, VES), an efficient inducer of apoptosis, acts as a potent agent for cancer therapy. However, the mechanism by which VES mediates the effects are not yet fully understood. Here we studied the effect of endoplasmic reticulum (ER) stress and unfolded protein response (UPR) on VES-induced apoptosis of SGC-7901 human gastric cancer cells. VES caused cytological changes typical of apoptosis, increased ER dilation and cytosolic Ca(2+) concentration. And endogenous ER stress markers, GRP78 and GRP94 were transcriptionally and translationally altered. In response to VES, induction of CHOP, activation of caspase-4 and JNK were observed. Furthermore, VES also triggered activation of UPR components, including RNA-dependent protein kinase (PKR)-like ER kinase (PERK), activating transcription factor 6 (ATF6), X-box-binding protein 1 (XBP1), and ATF4 in a concentration- and time-dependent manner. Consequently, our results suggest that VES-induced apoptosis is coupled to ER stress and UPR activation in SGC-7901 human gastric cancer cells.

Authors+Show Affiliations

Department of Nutrition and Food, Harbin Medical University, Harbin, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20435408

Citation

Huang, Xiaoli, et al. "Endoplasmic Reticulum Stress Contributes to Vitamin E Succinate-induced Apoptosis in Human Gastric Cancer SGC-7901 Cells." Cancer Letters, vol. 296, no. 1, 2010, pp. 123-31.
Huang X, Zhang Z, Jia L, et al. Endoplasmic reticulum stress contributes to vitamin E succinate-induced apoptosis in human gastric cancer SGC-7901 cells. Cancer Lett. 2010;296(1):123-31.
Huang, X., Zhang, Z., Jia, L., Zhao, Y., Zhang, X., & Wu, K. (2010). Endoplasmic reticulum stress contributes to vitamin E succinate-induced apoptosis in human gastric cancer SGC-7901 cells. Cancer Letters, 296(1), 123-31. https://doi.org/10.1016/j.canlet.2010.04.002
Huang X, et al. Endoplasmic Reticulum Stress Contributes to Vitamin E Succinate-induced Apoptosis in Human Gastric Cancer SGC-7901 Cells. Cancer Lett. 2010 Oct 1;296(1):123-31. PubMed PMID: 20435408.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endoplasmic reticulum stress contributes to vitamin E succinate-induced apoptosis in human gastric cancer SGC-7901 cells. AU - Huang,Xiaoli, AU - Zhang,Zhihong, AU - Jia,Li, AU - Zhao,Yan, AU - Zhang,Xuguang, AU - Wu,Kun, PY - 2010/03/01/received PY - 2010/04/02/revised PY - 2010/04/08/accepted PY - 2010/5/4/entrez PY - 2010/5/4/pubmed PY - 2010/8/11/medline SP - 123 EP - 31 JF - Cancer letters JO - Cancer Lett VL - 296 IS - 1 N2 - Vitamin E succinate (RRR-alpha-tocopheryl succinate, VES), an efficient inducer of apoptosis, acts as a potent agent for cancer therapy. However, the mechanism by which VES mediates the effects are not yet fully understood. Here we studied the effect of endoplasmic reticulum (ER) stress and unfolded protein response (UPR) on VES-induced apoptosis of SGC-7901 human gastric cancer cells. VES caused cytological changes typical of apoptosis, increased ER dilation and cytosolic Ca(2+) concentration. And endogenous ER stress markers, GRP78 and GRP94 were transcriptionally and translationally altered. In response to VES, induction of CHOP, activation of caspase-4 and JNK were observed. Furthermore, VES also triggered activation of UPR components, including RNA-dependent protein kinase (PKR)-like ER kinase (PERK), activating transcription factor 6 (ATF6), X-box-binding protein 1 (XBP1), and ATF4 in a concentration- and time-dependent manner. Consequently, our results suggest that VES-induced apoptosis is coupled to ER stress and UPR activation in SGC-7901 human gastric cancer cells. SN - 1872-7980 UR - https://www.unboundmedicine.com/medline/citation/20435408/Endoplasmic_reticulum_stress_contributes_to_vitamin_E_succinate_induced_apoptosis_in_human_gastric_cancer_SGC_7901_cells_ DB - PRIME DP - Unbound Medicine ER -