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Evolving spectrum: the pathogenesis of endometriosis.
Clin Obstet Gynecol. 2010 Jun; 53(2):379-88.CO

Abstract

Although the exact etiology of endometriosis is unknown, several hypotheses about its origin exist. Of these, Sampson's theory of retrograde menstruation is the most widely accepted. Multiple in-vitro and in vivo models have been developed to study endometriosis. Several key steps are required to establish an endometriotic implant: presence of ectopic endometrial glands and stroma, attachment of endometrial cells to the peritoneum, invasion into the mesothelium, and survival and growth of the ectopic tissue. Many of these steps are similar to those associated with neoplasia, and numerous biologic pathways are involved. It is likely that both intrinsic factors within the ectopic endometrium and permissive alterations within the host are important to the development of endometriosis.

Authors+Show Affiliations

Division of Reproductive Medicine, Mayo Clinic, Rochester, Minnesota, MN 55901, USA.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20436314

Citation

Jensen, Jani R., and Charles C. Coddington. "Evolving Spectrum: the Pathogenesis of Endometriosis." Clinical Obstetrics and Gynecology, vol. 53, no. 2, 2010, pp. 379-88.
Jensen JR, Coddington CC. Evolving spectrum: the pathogenesis of endometriosis. Clin Obstet Gynecol. 2010;53(2):379-88.
Jensen, J. R., & Coddington, C. C. (2010). Evolving spectrum: the pathogenesis of endometriosis. Clinical Obstetrics and Gynecology, 53(2), 379-88. https://doi.org/10.1097/GRF.0b013e3181db7b84
Jensen JR, Coddington CC. Evolving Spectrum: the Pathogenesis of Endometriosis. Clin Obstet Gynecol. 2010;53(2):379-88. PubMed PMID: 20436314.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evolving spectrum: the pathogenesis of endometriosis. AU - Jensen,Jani R, AU - Coddington,Charles C,3rd PY - 2010/5/4/entrez PY - 2010/5/4/pubmed PY - 2010/9/21/medline SP - 379 EP - 88 JF - Clinical obstetrics and gynecology JO - Clin Obstet Gynecol VL - 53 IS - 2 N2 - Although the exact etiology of endometriosis is unknown, several hypotheses about its origin exist. Of these, Sampson's theory of retrograde menstruation is the most widely accepted. Multiple in-vitro and in vivo models have been developed to study endometriosis. Several key steps are required to establish an endometriotic implant: presence of ectopic endometrial glands and stroma, attachment of endometrial cells to the peritoneum, invasion into the mesothelium, and survival and growth of the ectopic tissue. Many of these steps are similar to those associated with neoplasia, and numerous biologic pathways are involved. It is likely that both intrinsic factors within the ectopic endometrium and permissive alterations within the host are important to the development of endometriosis. SN - 1532-5520 UR - https://www.unboundmedicine.com/medline/citation/20436314/Evolving_spectrum:_the_pathogenesis_of_endometriosis_ L2 - https://dx.doi.org/10.1097/GRF.0b013e3181db7b84 DB - PRIME DP - Unbound Medicine ER -