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[Gender, age and plasma lipids differences associated with apolipoprotein E polymorphism in school children].
Biomedica 2009; 29(3):382-91B

Abstract

INTRODUCTION

Apolipoprotein E (apoE) polymorphism is a genetic determinant of total cholesterol and LDL-c levels. Several studies have examined the relationship between variations at the APO E and cardiovascular disease. It is important to determine this relationship in the Colombian population.

OBJECTIVES

The relationship of apoE polymorphisms was associated with lipid profile by age and sex.

MATERIALS AND METHODS

A sample of 500 children aged 8 to 18 years, were selected from school populations in Quindio Province, Colombia. ApoE genotypes were determined by polymerase chain reaction and restriction enzyme. Lipid profiles were obtained by commercial kits.

RESULTS

The apoE allele frequencies were as follows: E3 - 91.6%, E2 - 5.3, and E4 - 3.1%. Genotypic frequencies were as follows: E3/E3 - 90.8%, E2/E3 - 5.6%, and E3/E4 - 3.2%. No homozygotes for E2/E2 and E4/E4 were recovered. Similar genotypic and allelic distribution was found for each gender. ApoE genotype and gender had a significant effect on total serum cholesterol (CT) and low density lipoprotein cholesterol (c-LDL). In boys these variables were related as follows: E4>E3>E2 (p<0.05); in girls the relationships were somewhat changed (E3>E4>E2). High density lipoprotein cholesterol (c-HDL) levels in boys were related as follows: E2>E4>E3; for girls, E4>E2>E3. In boys, for all variables, the protector effect was in E2; but in girls this allele was only a protector for CT and c-LDL, For triacylglycerol (TAG), very low density lipoprotein cholesterol (c-VLDL) and c-HDL, this the protector effect was associated with the E4 allele, (p<0.05).

CONCLUSION

The results suggested that modulation of apoE genotype on plasma lipids was influenced by gender and age, especially in girls older than 10 years.

Authors+Show Affiliations

Universidad del Quindío, Armenia, Colombia. plandazu@uniquindio.edu.co <plandazu@uniquindio.edu.co>No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

spa

PubMed ID

20436990

Citation

Landázuri, Patricia, et al. "[Gender, Age and Plasma Lipids Differences Associated With Apolipoprotein E Polymorphism in School Children]." Biomedica : Revista Del Instituto Nacional De Salud, vol. 29, no. 3, 2009, pp. 382-91.
Landázuri P, Loango N, Gallego ML, et al. [Gender, age and plasma lipids differences associated with apolipoprotein E polymorphism in school children]. Biomedica. 2009;29(3):382-91.
Landázuri, P., Loango, N., Gallego, M. L., & Restrepo, B. (2009). [Gender, age and plasma lipids differences associated with apolipoprotein E polymorphism in school children]. Biomedica : Revista Del Instituto Nacional De Salud, 29(3), pp. 382-91.
Landázuri P, et al. [Gender, Age and Plasma Lipids Differences Associated With Apolipoprotein E Polymorphism in School Children]. Biomedica. 2009;29(3):382-91. PubMed PMID: 20436990.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Gender, age and plasma lipids differences associated with apolipoprotein E polymorphism in school children]. AU - Landázuri,Patricia, AU - Loango,Nelsy, AU - Gallego,Martha Lucía, AU - Restrepo,Beatriz, PY - 2008/08/04/received PY - 2009/03/13/accepted PY - 2010/5/4/entrez PY - 2010/5/4/pubmed PY - 2010/8/27/medline SP - 382 EP - 91 JF - Biomedica : revista del Instituto Nacional de Salud JO - Biomedica VL - 29 IS - 3 N2 - INTRODUCTION: Apolipoprotein E (apoE) polymorphism is a genetic determinant of total cholesterol and LDL-c levels. Several studies have examined the relationship between variations at the APO E and cardiovascular disease. It is important to determine this relationship in the Colombian population. OBJECTIVES: The relationship of apoE polymorphisms was associated with lipid profile by age and sex. MATERIALS AND METHODS: A sample of 500 children aged 8 to 18 years, were selected from school populations in Quindio Province, Colombia. ApoE genotypes were determined by polymerase chain reaction and restriction enzyme. Lipid profiles were obtained by commercial kits. RESULTS: The apoE allele frequencies were as follows: E3 - 91.6%, E2 - 5.3, and E4 - 3.1%. Genotypic frequencies were as follows: E3/E3 - 90.8%, E2/E3 - 5.6%, and E3/E4 - 3.2%. No homozygotes for E2/E2 and E4/E4 were recovered. Similar genotypic and allelic distribution was found for each gender. ApoE genotype and gender had a significant effect on total serum cholesterol (CT) and low density lipoprotein cholesterol (c-LDL). In boys these variables were related as follows: E4>E3>E2 (p<0.05); in girls the relationships were somewhat changed (E3>E4>E2). High density lipoprotein cholesterol (c-HDL) levels in boys were related as follows: E2>E4>E3; for girls, E4>E2>E3. In boys, for all variables, the protector effect was in E2; but in girls this allele was only a protector for CT and c-LDL, For triacylglycerol (TAG), very low density lipoprotein cholesterol (c-VLDL) and c-HDL, this the protector effect was associated with the E4 allele, (p<0.05). CONCLUSION: The results suggested that modulation of apoE genotype on plasma lipids was influenced by gender and age, especially in girls older than 10 years. SN - 0120-4157 UR - https://www.unboundmedicine.com/medline/citation/20436990/[Gender_age_and_plasma_lipids_differences_associated_with_apolipoprotein_E_polymorphism_in_school_children]_ L2 - https://medlineplus.gov/cholesterollevelswhatyouneedtoknow.html DB - PRIME DP - Unbound Medicine ER -