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Crossover trial of gabapentin and memantine as treatment for acquired nystagmus.
Ann Neurol. 2010 May; 67(5):676-80.AN

Abstract

We conducted a masked, crossover, therapeutic trial of gabapentin (1,200mg/day) versus memantine (40 mg/day) for acquired nystagmus in 10 patients (aged 28-61 years; 7 female; 3 multiple sclerosis [MS]; 6 post-stroke; 1 post-traumatic). Nystagmus was pendular in 6 patients (4 oculopalatal tremor; 2 MS) and jerk upbeat, hemi-seesaw, torsional, or upbeat-diagonal in each of the others. For the group, both drugs reduced median eye speed (p < 0.001), gabapentin by 32.8% and memantine by 27.8%, and improved visual acuity (p < 0.05). Each patient improved with 1 or both drugs. Side effects included unsteadiness with gabapentin and lethargy with memantine. Both drugs should be considered as treatment for acquired forms of nystagmus.

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Publisher Full Text
ncbi.nlm.nih.gov
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Authors+Show Affiliations

Thurtell MJ
Neurology Service, Veterans Affairs Medical Center, Cleveland OH, USA.
Joshi AC
No affiliation info available
Leone AC
No affiliation info available
Tomsak RL
No affiliation info available
Kosmorsky GS
No affiliation info available
Stahl JS
No affiliation info available
Leigh RJ
No affiliation info available

MeSH

AdultAminesCross-Over StudiesCyclohexanecarboxylic AcidsExcitatory Amino Acid AntagonistsEye MovementsFemaleGabapentinHumansMaleMemantineMiddle AgedNystagmus, Pathologicgamma-Aminobutyric Acid

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

20437565

Citation

Thurtell, Matthew J., et al. "Crossover Trial of Gabapentin and Memantine as Treatment for Acquired Nystagmus." Annals of Neurology, vol. 67, no. 5, 2010, pp. 676-80.
Thurtell MJ, Joshi AC, Leone AC, et al. Crossover trial of gabapentin and memantine as treatment for acquired nystagmus. Ann Neurol. 2010;67(5):676-80.
Thurtell, M. J., Joshi, A. C., Leone, A. C., Tomsak, R. L., Kosmorsky, G. S., Stahl, J. S., & Leigh, R. J. (2010). Crossover trial of gabapentin and memantine as treatment for acquired nystagmus. Annals of Neurology, 67(5), 676-80. https://doi.org/10.1002/ana.21991
Thurtell MJ, et al. Crossover Trial of Gabapentin and Memantine as Treatment for Acquired Nystagmus. Ann Neurol. 2010;67(5):676-80. PubMed PMID: 20437565.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Crossover trial of gabapentin and memantine as treatment for acquired nystagmus. AU - Thurtell,Matthew J, AU - Joshi,Anand C, AU - Leone,Alice C, AU - Tomsak,Robert L, AU - Kosmorsky,Gregory S, AU - Stahl,John S, AU - Leigh,R John, PY - 2010/5/4/entrez PY - 2010/5/4/pubmed PY - 2010/5/19/medline SP - 676 EP - 80 JF - Annals of neurology JO - Ann Neurol VL - 67 IS - 5 N2 - We conducted a masked, crossover, therapeutic trial of gabapentin (1,200mg/day) versus memantine (40 mg/day) for acquired nystagmus in 10 patients (aged 28-61 years; 7 female; 3 multiple sclerosis [MS]; 6 post-stroke; 1 post-traumatic). Nystagmus was pendular in 6 patients (4 oculopalatal tremor; 2 MS) and jerk upbeat, hemi-seesaw, torsional, or upbeat-diagonal in each of the others. For the group, both drugs reduced median eye speed (p < 0.001), gabapentin by 32.8% and memantine by 27.8%, and improved visual acuity (p < 0.05). Each patient improved with 1 or both drugs. Side effects included unsteadiness with gabapentin and lethargy with memantine. Both drugs should be considered as treatment for acquired forms of nystagmus. SN - 1531-8249 UR - https://www.unboundmedicine.com/medline/citation/20437565/Crossover_trial_of_gabapentin_and_memantine_as_treatment_for_acquired_nystagmus_ L2 - https://doi.org/10.1002/ana.21991 DB - PRIME DP - Unbound Medicine ER -