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Evidence that part of the NANC relaxant response of guinea-pig trachea to electrical field stimulation is mediated by nitric oxide.
Br J Pharmacol. 1991 Jan; 102(1):91-4.BJ

Abstract

1. The nitric oxide (NO) synthesis inhibitors NG-monomethyl L-arginine (L-NMMA) and L-nitroarginine methyl ester (L-NAME) reduced relaxations of guinea-pig tracheal smooth muscle elicited by stimulation of intramural non-adrenergic, non-cholinergic (NANC) nerves, but D-NMMA had no effect. L-NAME was 10-30 times more potent than L-NMMA. Relaxations produced by sodium nitroprusside and vasoactive intestinal polypeptide (VIP) were not affected by L-NMMA or L-NAME. 2. The inhibitory effect of L-NMMA on NANC-mediated relaxations was partially reversed by L-arginine but was not affected by D-arginine. 3. VIP antibody and alpha-chymotrypsin abolished or greatly reduced the relaxant action of VIP and reduced relaxations elicited by stimulation of NANC nerves; the residual NANC relaxation was further reduced by L-NAME. 4. The results suggest that NO and VIP are mediators of NANC-induced relaxations of guinea-pig tracheal smooth muscle. We propose the term 'nitrergic' to describe transmission processes which are mediated by NO.

Authors+Show Affiliations

Department of Pharmacology, University of Melbourne, Victoria, Australia.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2043935

Citation

Li, C G., and M J. Rand. "Evidence That Part of the NANC Relaxant Response of Guinea-pig Trachea to Electrical Field Stimulation Is Mediated By Nitric Oxide." British Journal of Pharmacology, vol. 102, no. 1, 1991, pp. 91-4.
Li CG, Rand MJ. Evidence that part of the NANC relaxant response of guinea-pig trachea to electrical field stimulation is mediated by nitric oxide. Br J Pharmacol. 1991;102(1):91-4.
Li, C. G., & Rand, M. J. (1991). Evidence that part of the NANC relaxant response of guinea-pig trachea to electrical field stimulation is mediated by nitric oxide. British Journal of Pharmacology, 102(1), 91-4.
Li CG, Rand MJ. Evidence That Part of the NANC Relaxant Response of Guinea-pig Trachea to Electrical Field Stimulation Is Mediated By Nitric Oxide. Br J Pharmacol. 1991;102(1):91-4. PubMed PMID: 2043935.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evidence that part of the NANC relaxant response of guinea-pig trachea to electrical field stimulation is mediated by nitric oxide. AU - Li,C G, AU - Rand,M J, PY - 1991/1/1/pubmed PY - 1991/1/1/medline PY - 1991/1/1/entrez SP - 91 EP - 4 JF - British journal of pharmacology JO - Br J Pharmacol VL - 102 IS - 1 N2 - 1. The nitric oxide (NO) synthesis inhibitors NG-monomethyl L-arginine (L-NMMA) and L-nitroarginine methyl ester (L-NAME) reduced relaxations of guinea-pig tracheal smooth muscle elicited by stimulation of intramural non-adrenergic, non-cholinergic (NANC) nerves, but D-NMMA had no effect. L-NAME was 10-30 times more potent than L-NMMA. Relaxations produced by sodium nitroprusside and vasoactive intestinal polypeptide (VIP) were not affected by L-NMMA or L-NAME. 2. The inhibitory effect of L-NMMA on NANC-mediated relaxations was partially reversed by L-arginine but was not affected by D-arginine. 3. VIP antibody and alpha-chymotrypsin abolished or greatly reduced the relaxant action of VIP and reduced relaxations elicited by stimulation of NANC nerves; the residual NANC relaxation was further reduced by L-NAME. 4. The results suggest that NO and VIP are mediators of NANC-induced relaxations of guinea-pig tracheal smooth muscle. We propose the term 'nitrergic' to describe transmission processes which are mediated by NO. SN - 0007-1188 UR - https://www.unboundmedicine.com/medline/citation/2043935/Evidence_that_part_of_the_NANC_relaxant_response_of_guinea_pig_trachea_to_electrical_field_stimulation_is_mediated_by_nitric_oxide_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0007-1188&date=1991&volume=102&issue=1&spage=91 DB - PRIME DP - Unbound Medicine ER -