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Correcting poor vitamin D status: do older adults need higher repletion doses of vitamin D3 than younger adults?
Mol Nutr Food Res 2010; 54(8):1077-84MN

Abstract

We conducted an examination of recent studies to determine whether older adults (>or=65 years) need higher levels of supplementary vitamin D than young adults when attempting to replete vitamin D status in deficient subjects, i.e. those with levels of 25-hydroxyvitamin D less than 75 nmol/L. As data on repletion with vitamin D(2) have recently been published, we restricted our discussion to the use of vitamin D(3) from dietary supplements, prescriptions for large oral doses, and bolus dosing or injections. Most published dosing regimens failed to achieve 75 nmol/L in most all subjects, whether young adults (<65 years) or older adults (>or=65 years). Whether as daily or bolus oral supplementation, elderly subjects appeared to need more vitamin D3 compared with younger adults, however, baseline levels, endpoints, study duration, compliance, and other factors were different among studies. To ensure most subjects are replete in vitamin D, a daily dose of more than 50 microg (2000 IU) in younger and 125 microg (5000 IU) is required. Other strategies including bolus and loading doses are described. No study reported adverse effects of using oral intakes about the current upper level of 50 microg (2000 IU).

Authors+Show Affiliations

College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada. susan.whiting@usask.caNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20440693

Citation

Whiting, Susan J., and Mona S. Calvo. "Correcting Poor Vitamin D Status: Do Older Adults Need Higher Repletion Doses of Vitamin D3 Than Younger Adults?" Molecular Nutrition & Food Research, vol. 54, no. 8, 2010, pp. 1077-84.
Whiting SJ, Calvo MS. Correcting poor vitamin D status: do older adults need higher repletion doses of vitamin D3 than younger adults? Mol Nutr Food Res. 2010;54(8):1077-84.
Whiting, S. J., & Calvo, M. S. (2010). Correcting poor vitamin D status: do older adults need higher repletion doses of vitamin D3 than younger adults? Molecular Nutrition & Food Research, 54(8), pp. 1077-84. doi:10.1002/mnfr.200900536.
Whiting SJ, Calvo MS. Correcting Poor Vitamin D Status: Do Older Adults Need Higher Repletion Doses of Vitamin D3 Than Younger Adults. Mol Nutr Food Res. 2010;54(8):1077-84. PubMed PMID: 20440693.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correcting poor vitamin D status: do older adults need higher repletion doses of vitamin D3 than younger adults? AU - Whiting,Susan J, AU - Calvo,Mona S, PY - 2010/5/5/entrez PY - 2010/5/5/pubmed PY - 2010/12/14/medline SP - 1077 EP - 84 JF - Molecular nutrition & food research JO - Mol Nutr Food Res VL - 54 IS - 8 N2 - We conducted an examination of recent studies to determine whether older adults (>or=65 years) need higher levels of supplementary vitamin D than young adults when attempting to replete vitamin D status in deficient subjects, i.e. those with levels of 25-hydroxyvitamin D less than 75 nmol/L. As data on repletion with vitamin D(2) have recently been published, we restricted our discussion to the use of vitamin D(3) from dietary supplements, prescriptions for large oral doses, and bolus dosing or injections. Most published dosing regimens failed to achieve 75 nmol/L in most all subjects, whether young adults (<65 years) or older adults (>or=65 years). Whether as daily or bolus oral supplementation, elderly subjects appeared to need more vitamin D3 compared with younger adults, however, baseline levels, endpoints, study duration, compliance, and other factors were different among studies. To ensure most subjects are replete in vitamin D, a daily dose of more than 50 microg (2000 IU) in younger and 125 microg (5000 IU) is required. Other strategies including bolus and loading doses are described. No study reported adverse effects of using oral intakes about the current upper level of 50 microg (2000 IU). SN - 1613-4133 UR - https://www.unboundmedicine.com/medline/citation/20440693/Correcting_poor_vitamin_D_status:_do_older_adults_need_higher_repletion_doses_of_vitamin_D3_than_younger_adults L2 - https://doi.org/10.1002/mnfr.200900536 DB - PRIME DP - Unbound Medicine ER -