Tags

Type your tag names separated by a space and hit enter

Rhodium(III)-catalyzed intermolecular hydroarylation of alkynes.
J Am Chem Soc. 2010 May 26; 132(20):6910-1.JA

Abstract

The rhodium(III)-catalyzed hydroarylation of internal alkynes is described. Good yields are obtained for a variety of alkynes, and excellent regioselectivity is observed for unsymmetrically substituted alkynes. The reaction also gives good yields for a range of arenes. Preliminary mechanistic investigations suggest that this reaction proceeds through arene metalation with the cationic rhodium catalyst, which enables challenging intermolecular reactivity.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Schipper DJ
Centre for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Ontario, Canada K1N 6N5. dschi064@uottawa.ca
Hutchinson M
No affiliation info available
Fagnou K
No affiliation info available

MeSH

AlkynesCatalysisRhodiumStereoisomerismSubstrate Specificity

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20441195

Citation

Schipper, Derek J., et al. "Rhodium(III)-catalyzed Intermolecular Hydroarylation of Alkynes." Journal of the American Chemical Society, vol. 132, no. 20, 2010, pp. 6910-1.
Schipper DJ, Hutchinson M, Fagnou K. Rhodium(III)-catalyzed intermolecular hydroarylation of alkynes. J Am Chem Soc. 2010;132(20):6910-1.
Schipper, D. J., Hutchinson, M., & Fagnou, K. (2010). Rhodium(III)-catalyzed intermolecular hydroarylation of alkynes. Journal of the American Chemical Society, 132(20), 6910-1. https://doi.org/10.1021/ja103080d
Schipper DJ, Hutchinson M, Fagnou K. Rhodium(III)-catalyzed Intermolecular Hydroarylation of Alkynes. J Am Chem Soc. 2010 May 26;132(20):6910-1. PubMed PMID: 20441195.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rhodium(III)-catalyzed intermolecular hydroarylation of alkynes. AU - Schipper,Derek J, AU - Hutchinson,Marieke, AU - Fagnou,Keith, PY - 2010/5/6/entrez PY - 2010/5/6/pubmed PY - 2010/8/12/medline SP - 6910 EP - 1 JF - Journal of the American Chemical Society JO - J Am Chem Soc VL - 132 IS - 20 N2 - The rhodium(III)-catalyzed hydroarylation of internal alkynes is described. Good yields are obtained for a variety of alkynes, and excellent regioselectivity is observed for unsymmetrically substituted alkynes. The reaction also gives good yields for a range of arenes. Preliminary mechanistic investigations suggest that this reaction proceeds through arene metalation with the cationic rhodium catalyst, which enables challenging intermolecular reactivity. SN - 1520-5126 UR - https://www.unboundmedicine.com/medline/citation/20441195/Rhodium_III__catalyzed_intermolecular_hydroarylation_of_alkynes_ L2 - https://doi.org/10.1021/ja103080d DB - PRIME DP - Unbound Medicine ER -