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Square-wave voltammetric determination of propranolol and atenolol in pharmaceuticals using a boron-doped diamond electrode.
Talanta. 2010 Jun 15; 81(4-5):1418-24.T

Abstract

The independent determination of two beta-blocker agents, namely propranolol (PROP) and atenolol (ATN), in pharmaceutical formulations using square-wave voltammetry and a cathodically pretreated boron-doped diamond electrode is described. These electroanalytical determinations of propranolol or atenolol were carried out in 0.1molL(-1) H(2)SO(4) or 0.5molL(-1) NaNO(3) (pH 1.0, adjusted with concentrated HNO(3)), respectively. Excellent linear calibration curves, ranging from 0.20 to 9.0micromolL(-1) for PROP and from 2.0 to 41micromolL(-1) for ATN, with detection limits of 0.18 and 0.93micromolL(-1), respectively, were obtained. The obtained recoveries range from 93.9% to 105.0%, for PROP, and from 92.5% to 106.0%, for ATN. The proposed method was successfully applied in the determination of both beta-blockers in several pharmaceutical formulations (tablets), with results in close agreement at a 95% confidence level with those obtained using official spectrophotometric methods.

Authors+Show Affiliations

Departamento de Química, Universidade Federal de São Carlos, São Carlos, SP, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20441917

Citation

Sartori, Elen Romão, et al. "Square-wave Voltammetric Determination of Propranolol and Atenolol in Pharmaceuticals Using a Boron-doped Diamond Electrode." Talanta, vol. 81, no. 4-5, 2010, pp. 1418-24.
Sartori ER, Medeiros RA, Rocha-Filho RC, et al. Square-wave voltammetric determination of propranolol and atenolol in pharmaceuticals using a boron-doped diamond electrode. Talanta. 2010;81(4-5):1418-24.
Sartori, E. R., Medeiros, R. A., Rocha-Filho, R. C., & Fatibello-Filho, O. (2010). Square-wave voltammetric determination of propranolol and atenolol in pharmaceuticals using a boron-doped diamond electrode. Talanta, 81(4-5), 1418-24. https://doi.org/10.1016/j.talanta.2010.02.046
Sartori ER, et al. Square-wave Voltammetric Determination of Propranolol and Atenolol in Pharmaceuticals Using a Boron-doped Diamond Electrode. Talanta. 2010 Jun 15;81(4-5):1418-24. PubMed PMID: 20441917.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Square-wave voltammetric determination of propranolol and atenolol in pharmaceuticals using a boron-doped diamond electrode. AU - Sartori,Elen Romão, AU - Medeiros,Roberta Antigo, AU - Rocha-Filho,Romeu C, AU - Fatibello-Filho,Orlando, Y1 - 2010/02/24/ PY - 2009/12/11/received PY - 2010/02/11/revised PY - 2010/02/15/accepted PY - 2010/5/6/entrez PY - 2010/5/6/pubmed PY - 2010/10/22/medline SP - 1418 EP - 24 JF - Talanta JO - Talanta VL - 81 IS - 4-5 N2 - The independent determination of two beta-blocker agents, namely propranolol (PROP) and atenolol (ATN), in pharmaceutical formulations using square-wave voltammetry and a cathodically pretreated boron-doped diamond electrode is described. These electroanalytical determinations of propranolol or atenolol were carried out in 0.1molL(-1) H(2)SO(4) or 0.5molL(-1) NaNO(3) (pH 1.0, adjusted with concentrated HNO(3)), respectively. Excellent linear calibration curves, ranging from 0.20 to 9.0micromolL(-1) for PROP and from 2.0 to 41micromolL(-1) for ATN, with detection limits of 0.18 and 0.93micromolL(-1), respectively, were obtained. The obtained recoveries range from 93.9% to 105.0%, for PROP, and from 92.5% to 106.0%, for ATN. The proposed method was successfully applied in the determination of both beta-blockers in several pharmaceutical formulations (tablets), with results in close agreement at a 95% confidence level with those obtained using official spectrophotometric methods. SN - 1873-3573 UR - https://www.unboundmedicine.com/medline/citation/20441917/Square_wave_voltammetric_determination_of_propranolol_and_atenolol_in_pharmaceuticals_using_a_boron_doped_diamond_electrode_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0039-9140(10)00161-X DB - PRIME DP - Unbound Medicine ER -