Tags

Type your tag names separated by a space and hit enter

Ultraviolet B irradiance and vitamin D status are inversely associated with incidence rates of pancreatic cancer worldwide.
Pancreas. 2010 Jul; 39(5):669-74.P

Abstract

OBJECTIVES

To determine if an inverse association exits between latitude, ultraviolet B (UVB) irradiance and incidence rates of pancreatic cancer worldwide.

METHODS

Multiple linear regression was used to investigate the relationship and between UVB irradiance incidence rates of pancreatic cancer and while controlling for cigarette, alcohol and sugar consumption, and proportion overweight. Serum 25-hydroxyvitamin D [25(OH)D] levels were estimated, and their association with incidence rates also was analyzed.

RESULTS

Incidence rates were higher at higher latitudes (R2 for latitude for men, 0.51; P < 0.001; R2 for latitude for women, 0.32; P < 0.001). Ultraviolet B irradiance also was independently inversely associated with incidence in men (P < 0.01) and women (P = 0.02). Alcohol (P < 0.0001) and cigarette (P < or = 0.01) consumption were positively associated with incidence in men (R2 for overall model for men, 0.76; P < 0.0001). Alcohol (P < 0.0001) and sugar (P = 0.001) consumption were positively associated with incidence rates in women (R2 for overall model for women, 0.64; P < 0.0001). Incidence rates were half as high in countries with estimated serum 25(OH)D >30 ng/mL (75 nmol/L) than in those with < or =30 ng/mL.

CONCLUSIONS

Countries with lower UVB irradiance had higher incidence rates of pancreatic cancer in both hemispheres, with occasional exceptions.

Authors+Show Affiliations

Naval Health Research Center, San Diego, CA, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

20442683

Citation

Mohr, Sharif B., et al. "Ultraviolet B Irradiance and Vitamin D Status Are Inversely Associated With Incidence Rates of Pancreatic Cancer Worldwide." Pancreas, vol. 39, no. 5, 2010, pp. 669-74.
Mohr SB, Garland CF, Gorham ED, et al. Ultraviolet B irradiance and vitamin D status are inversely associated with incidence rates of pancreatic cancer worldwide. Pancreas. 2010;39(5):669-74.
Mohr, S. B., Garland, C. F., Gorham, E. D., Grant, W. B., & Garland, F. C. (2010). Ultraviolet B irradiance and vitamin D status are inversely associated with incidence rates of pancreatic cancer worldwide. Pancreas, 39(5), 669-74. https://doi.org/10.1097/MPA.0b013e3181ce654d
Mohr SB, et al. Ultraviolet B Irradiance and Vitamin D Status Are Inversely Associated With Incidence Rates of Pancreatic Cancer Worldwide. Pancreas. 2010;39(5):669-74. PubMed PMID: 20442683.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ultraviolet B irradiance and vitamin D status are inversely associated with incidence rates of pancreatic cancer worldwide. AU - Mohr,Sharif B, AU - Garland,Cedric F, AU - Gorham,Edward D, AU - Grant,William B, AU - Garland,Frank C, PY - 2010/5/6/entrez PY - 2010/5/6/pubmed PY - 2010/10/12/medline SP - 669 EP - 74 JF - Pancreas JO - Pancreas VL - 39 IS - 5 N2 - OBJECTIVES: To determine if an inverse association exits between latitude, ultraviolet B (UVB) irradiance and incidence rates of pancreatic cancer worldwide. METHODS: Multiple linear regression was used to investigate the relationship and between UVB irradiance incidence rates of pancreatic cancer and while controlling for cigarette, alcohol and sugar consumption, and proportion overweight. Serum 25-hydroxyvitamin D [25(OH)D] levels were estimated, and their association with incidence rates also was analyzed. RESULTS: Incidence rates were higher at higher latitudes (R2 for latitude for men, 0.51; P < 0.001; R2 for latitude for women, 0.32; P < 0.001). Ultraviolet B irradiance also was independently inversely associated with incidence in men (P < 0.01) and women (P = 0.02). Alcohol (P < 0.0001) and cigarette (P < or = 0.01) consumption were positively associated with incidence in men (R2 for overall model for men, 0.76; P < 0.0001). Alcohol (P < 0.0001) and sugar (P = 0.001) consumption were positively associated with incidence rates in women (R2 for overall model for women, 0.64; P < 0.0001). Incidence rates were half as high in countries with estimated serum 25(OH)D >30 ng/mL (75 nmol/L) than in those with < or =30 ng/mL. CONCLUSIONS: Countries with lower UVB irradiance had higher incidence rates of pancreatic cancer in both hemispheres, with occasional exceptions. SN - 1536-4828 UR - https://www.unboundmedicine.com/medline/citation/20442683/Ultraviolet_B_irradiance_and_vitamin_D_status_are_inversely_associated_with_incidence_rates_of_pancreatic_cancer_worldwide_ L2 - http://dx.doi.org/10.1097/MPA.0b013e3181ce654d DB - PRIME DP - Unbound Medicine ER -