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Does dietary protein reduce hip fracture risk in elders? The Framingham Osteoporosis Study.
Osteoporos Int 2011; 22(1):345-9OI

Abstract

Association between dietary protein and fracture risk is unclear. We examined association between energy-adjusted protein intake and hip fracture risk in elders. The risk of hip fracture was reduced in upper quartiles of protein intake when compared with lowest quartile.

INTRODUCTION

Studies of the association between dietary protein intake and hip fracture risk are conflicting. Therefore, we examined protein intake and hip fracture risk in a population-based group of elderly men and women.

METHODS

Five hundred seventy-six women and 370 men from the Framingham Osteoporosis Study with no previous history of hip fracture completed Food Frequency Questionnaires. Energy-adjusted protein intake was evaluated as a continuous variable and as quartiles. Incidence rates and hazard ratios were calculated, adjusting for age, BMI, sex, and energy intake.

RESULTS

Among 946 participants (mean age 75 years), mean protein intake was found to be 68 gm/d. Increased protein intake was associated with a decreased risk of hip fracture compared to those in the lowest quartile of protein intake (Q2 HR = 0.70, Q3 HR = 0.56, and Q4 HR = 0.63; all p values ≥ 0.044), p for trend was 0.07. When a threshold effect was considered (Q2-4 vs Q1), intakes in the higher quartiles combined were associated with a significantly lower risk for hip fracture (HR = 0.63; p = 0.04).

CONCLUSION

Our results are consistent with reduced risk of hip fracture with higher dietary protein intake. Larger prospective studies are needed to confirm and extend this finding in elderly men and women.

Authors+Show Affiliations

Department of Rheumatology, Boston University Medical Center, Boston, MA, USA. devyani.misra@bmc.org

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

20442986

Citation

Misra, D, et al. "Does Dietary Protein Reduce Hip Fracture Risk in Elders? the Framingham Osteoporosis Study." Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, vol. 22, no. 1, 2011, pp. 345-9.
Misra D, Berry SD, Broe KE, et al. Does dietary protein reduce hip fracture risk in elders? The Framingham Osteoporosis Study. Osteoporos Int. 2011;22(1):345-9.
Misra, D., Berry, S. D., Broe, K. E., McLean, R. R., Cupples, L. A., Tucker, K. L., ... Hannan, M. T. (2011). Does dietary protein reduce hip fracture risk in elders? The Framingham Osteoporosis Study. Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 22(1), pp. 345-9. doi:10.1007/s00198-010-1179-4.
Misra D, et al. Does Dietary Protein Reduce Hip Fracture Risk in Elders? the Framingham Osteoporosis Study. Osteoporos Int. 2011;22(1):345-9. PubMed PMID: 20442986.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does dietary protein reduce hip fracture risk in elders? The Framingham Osteoporosis Study. AU - Misra,D, AU - Berry,S D, AU - Broe,K E, AU - McLean,R R, AU - Cupples,L A, AU - Tucker,K L, AU - Kiel,D P, AU - Hannan,M T, Y1 - 2010/05/05/ PY - 2009/08/11/received PY - 2009/12/18/accepted PY - 2010/5/6/entrez PY - 2010/5/6/pubmed PY - 2011/8/31/medline SP - 345 EP - 9 JF - Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA JO - Osteoporos Int VL - 22 IS - 1 N2 - UNLABELLED: Association between dietary protein and fracture risk is unclear. We examined association between energy-adjusted protein intake and hip fracture risk in elders. The risk of hip fracture was reduced in upper quartiles of protein intake when compared with lowest quartile. INTRODUCTION: Studies of the association between dietary protein intake and hip fracture risk are conflicting. Therefore, we examined protein intake and hip fracture risk in a population-based group of elderly men and women. METHODS: Five hundred seventy-six women and 370 men from the Framingham Osteoporosis Study with no previous history of hip fracture completed Food Frequency Questionnaires. Energy-adjusted protein intake was evaluated as a continuous variable and as quartiles. Incidence rates and hazard ratios were calculated, adjusting for age, BMI, sex, and energy intake. RESULTS: Among 946 participants (mean age 75 years), mean protein intake was found to be 68 gm/d. Increased protein intake was associated with a decreased risk of hip fracture compared to those in the lowest quartile of protein intake (Q2 HR = 0.70, Q3 HR = 0.56, and Q4 HR = 0.63; all p values ≥ 0.044), p for trend was 0.07. When a threshold effect was considered (Q2-4 vs Q1), intakes in the higher quartiles combined were associated with a significantly lower risk for hip fracture (HR = 0.63; p = 0.04). CONCLUSION: Our results are consistent with reduced risk of hip fracture with higher dietary protein intake. Larger prospective studies are needed to confirm and extend this finding in elderly men and women. SN - 1433-2965 UR - https://www.unboundmedicine.com/medline/citation/20442986/Does_dietary_protein_reduce_hip_fracture_risk_in_elders_The_Framingham_Osteoporosis_Study_ L2 - https://dx.doi.org/10.1007/s00198-010-1179-4 DB - PRIME DP - Unbound Medicine ER -