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A meta-analysis of alcohol drinking and oral and pharyngeal cancers. Part 1: overall results and dose-risk relation.
Oral Oncol 2010; 46(7):497-503OO

Abstract

Alcohol consumption, together with tobacco, is the best recognised risk factor for oral and pharyngeal cancers (OPC), but several important aspects of this association need to be further explored. In order to provide up to date and more precise quantification of the association between alcohol drinking and OPC risk, we conducted a meta-analysis of available data. We performed a PubMed search of articles published up to September 2009, and we identified 43 case-control and two cohort studies presenting results for at least three categories of alcohol drinking, including a total of 17,085 OPC cases. We derived meta-analytic summary estimates using random-effects models, and taking into account correlation between estimates. We also performed a dose-risk analysis using non-linear random-effects meta-regression models. The pooled relative risk (RR) was 1.21 (95% confidence interval, CI, 1.10-1.33) for <or=1 drink per day, and rose to 5.24 (95% CI, 4.36-6.30) for heavy alcohol drinking (>or=4 drinks per day). The dose-risk analysis resulted in RR of 1.29 for 10g ethanol/day, 3.24 for 50g ethanol/day, 8.61 for 100g ethanol/day, and 13.02 for 125g ethanol/day. This meta-analysis provides more precise evidence of a gross excess of OPC risk for heavy alcohol drinkers. It also indicates an increased risk for moderate doses, i.e., <or=1 drink or 10g ethanol/day.

Authors+Show Affiliations

Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

20444641

Citation

Tramacere, Irene, et al. "A Meta-analysis of Alcohol Drinking and Oral and Pharyngeal Cancers. Part 1: Overall Results and Dose-risk Relation." Oral Oncology, vol. 46, no. 7, 2010, pp. 497-503.
Tramacere I, Negri E, Bagnardi V, et al. A meta-analysis of alcohol drinking and oral and pharyngeal cancers. Part 1: overall results and dose-risk relation. Oral Oncol. 2010;46(7):497-503.
Tramacere, I., Negri, E., Bagnardi, V., Garavello, W., Rota, M., Scotti, L., ... La Vecchia, C. (2010). A meta-analysis of alcohol drinking and oral and pharyngeal cancers. Part 1: overall results and dose-risk relation. Oral Oncology, 46(7), pp. 497-503. doi:10.1016/j.oraloncology.2010.03.024.
Tramacere I, et al. A Meta-analysis of Alcohol Drinking and Oral and Pharyngeal Cancers. Part 1: Overall Results and Dose-risk Relation. Oral Oncol. 2010;46(7):497-503. PubMed PMID: 20444641.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A meta-analysis of alcohol drinking and oral and pharyngeal cancers. Part 1: overall results and dose-risk relation. AU - Tramacere,Irene, AU - Negri,Eva, AU - Bagnardi,Vincenzo, AU - Garavello,Werner, AU - Rota,Matteo, AU - Scotti,Lorenza, AU - Islami,Farhad, AU - Corrao,Giovanni, AU - Boffetta,Paolo, AU - La Vecchia,Carlo, Y1 - 2010/05/04/ PY - 2010/02/22/received PY - 2010/03/30/revised PY - 2010/03/30/accepted PY - 2010/5/7/entrez PY - 2010/5/7/pubmed PY - 2011/4/19/medline SP - 497 EP - 503 JF - Oral oncology JO - Oral Oncol. VL - 46 IS - 7 N2 - Alcohol consumption, together with tobacco, is the best recognised risk factor for oral and pharyngeal cancers (OPC), but several important aspects of this association need to be further explored. In order to provide up to date and more precise quantification of the association between alcohol drinking and OPC risk, we conducted a meta-analysis of available data. We performed a PubMed search of articles published up to September 2009, and we identified 43 case-control and two cohort studies presenting results for at least three categories of alcohol drinking, including a total of 17,085 OPC cases. We derived meta-analytic summary estimates using random-effects models, and taking into account correlation between estimates. We also performed a dose-risk analysis using non-linear random-effects meta-regression models. The pooled relative risk (RR) was 1.21 (95% confidence interval, CI, 1.10-1.33) for <or=1 drink per day, and rose to 5.24 (95% CI, 4.36-6.30) for heavy alcohol drinking (>or=4 drinks per day). The dose-risk analysis resulted in RR of 1.29 for 10g ethanol/day, 3.24 for 50g ethanol/day, 8.61 for 100g ethanol/day, and 13.02 for 125g ethanol/day. This meta-analysis provides more precise evidence of a gross excess of OPC risk for heavy alcohol drinkers. It also indicates an increased risk for moderate doses, i.e., <or=1 drink or 10g ethanol/day. SN - 1879-0593 UR - https://www.unboundmedicine.com/medline/citation/20444641/A_meta_analysis_of_alcohol_drinking_and_oral_and_pharyngeal_cancers__Part_1:_overall_results_and_dose_risk_relation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1368-8375(10)00136-3 DB - PRIME DP - Unbound Medicine ER -