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Stability of hemoglobin mass during a 6-day UCI ProTour cycling race.
Clin J Sport Med. 2010 May; 20(3):200-4.CJ

Abstract

OBJECTIVE

Blood doping in endurance sport is a growing problem. The purpose of this study was to determine the reliability of total hemoglobin mass (Hb(mass)) measurement in the field and to establish the variability of Hb(mass) during a cycling race, to assess its viability as an additional antidoping detection parameter.

DESIGN

Control-matched longitudinal study.

SETTING

International Cycling Union's (UCI) ProTour stage race.

PARTICIPANTS

Six professional cyclists and 5 recreationally active controls.

INTERVENTIONS

Seventy-two Hb(mass) tests using the optimized carbon monoxide rebreathing method were performed over 7 consecutive days, before and throughout the tour. Fasted venous blood was obtained for measurement of hematocrit (Hct) and hemoglobin concentration [Hb] in the morning before stages 1, 3, and 6 (D1, D3, and D6).

MAIN OUTCOME MEASURES

Reliability of Hb(mass) measurement was established using typical error calculated from 2 baseline measures. Individual change scores and coefficients of variation were used to assess stability during racing.

RESULTS

Typical error for Hb(mass) was 1.3% [95% confidence limits (CL): 0.9%, 2.5%]. Calculated 95% and 99.99% CL for percent change in Hb(mass) were +/-3.6% and +/-7.2%, respectively. Mean Hb(mass) remained within +/-1.9% of baseline in cyclists and +/-0.5% in controls. In all cases, individual change scores for both cyclists and controls fell within the 95% CL. There was a decrease in Hct (8.1% +/- 2.8%) and [Hb] (9.7% +/- 3.2%) throughout the tour in cyclists but not in controls.

CONCLUSIONS

We demonstrate that Hb(mass) can be measured reliably via CO-rebreathing during a cycling tour. Unlike [Hb] and Hct, Hb(mass) remains stable over 6 days of racing in professional cyclists and may have potential in an antidoping context.

Links

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Authors+Show Affiliations

Garvican LA
Department of Physiology, Australian Institute of Sport, Canberra, Australia. laura.garvican@ausport.gov.au
Eastwood A
No affiliation info available
Martin DT
No affiliation info available
Ross ML
No affiliation info available
Gripper A
No affiliation info available
Gore CJ
No affiliation info available

MeSH

AdultBicyclingCarbon MonoxideDoping in SportsHemoglobinsHumansLongitudinal StudiesMalePhysical ExertionReproducibility of ResultsYoung Adult

Pub Type(s)

Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20445361

Citation

Garvican, Laura A., et al. "Stability of Hemoglobin Mass During a 6-day UCI ProTour Cycling Race." Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine, vol. 20, no. 3, 2010, pp. 200-4.
Garvican LA, Eastwood A, Martin DT, et al. Stability of hemoglobin mass during a 6-day UCI ProTour cycling race. Clin J Sport Med. 2010;20(3):200-4.
Garvican, L. A., Eastwood, A., Martin, D. T., Ross, M. L., Gripper, A., & Gore, C. J. (2010). Stability of hemoglobin mass during a 6-day UCI ProTour cycling race. Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine, 20(3), 200-4. https://doi.org/10.1097/JSM.0b013e3181ddcd5b
Garvican LA, et al. Stability of Hemoglobin Mass During a 6-day UCI ProTour Cycling Race. Clin J Sport Med. 2010;20(3):200-4. PubMed PMID: 20445361.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stability of hemoglobin mass during a 6-day UCI ProTour cycling race. AU - Garvican,Laura A, AU - Eastwood,Annette, AU - Martin,David T, AU - Ross,Megan L R, AU - Gripper,Anne, AU - Gore,Christopher J, PY - 2010/5/7/entrez PY - 2010/5/7/pubmed PY - 2010/8/27/medline SP - 200 EP - 4 JF - Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine JO - Clin J Sport Med VL - 20 IS - 3 N2 - OBJECTIVE: Blood doping in endurance sport is a growing problem. The purpose of this study was to determine the reliability of total hemoglobin mass (Hb(mass)) measurement in the field and to establish the variability of Hb(mass) during a cycling race, to assess its viability as an additional antidoping detection parameter. DESIGN: Control-matched longitudinal study. SETTING: International Cycling Union's (UCI) ProTour stage race. PARTICIPANTS: Six professional cyclists and 5 recreationally active controls. INTERVENTIONS: Seventy-two Hb(mass) tests using the optimized carbon monoxide rebreathing method were performed over 7 consecutive days, before and throughout the tour. Fasted venous blood was obtained for measurement of hematocrit (Hct) and hemoglobin concentration [Hb] in the morning before stages 1, 3, and 6 (D1, D3, and D6). MAIN OUTCOME MEASURES: Reliability of Hb(mass) measurement was established using typical error calculated from 2 baseline measures. Individual change scores and coefficients of variation were used to assess stability during racing. RESULTS: Typical error for Hb(mass) was 1.3% [95% confidence limits (CL): 0.9%, 2.5%]. Calculated 95% and 99.99% CL for percent change in Hb(mass) were +/-3.6% and +/-7.2%, respectively. Mean Hb(mass) remained within +/-1.9% of baseline in cyclists and +/-0.5% in controls. In all cases, individual change scores for both cyclists and controls fell within the 95% CL. There was a decrease in Hct (8.1% +/- 2.8%) and [Hb] (9.7% +/- 3.2%) throughout the tour in cyclists but not in controls. CONCLUSIONS: We demonstrate that Hb(mass) can be measured reliably via CO-rebreathing during a cycling tour. Unlike [Hb] and Hct, Hb(mass) remains stable over 6 days of racing in professional cyclists and may have potential in an antidoping context. SN - 1536-3724 UR - https://www.unboundmedicine.com/medline/citation/20445361/Stability_of_hemoglobin_mass_during_a_6_day_UCI_ProTour_cycling_race_ L2 - https://doi.org/10.1097/JSM.0b013e3181ddcd5b DB - PRIME DP - Unbound Medicine ER -