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White matter in aging and cognition: a cross-sectional study of microstructure in adults aged eighteen to eighty-three.
Dev Neuropsychol 2010; 35(3):257-77DN

Abstract

Structural brain change and concomitant cognitive decline are the seemingly unavoidable escorts of aging. Despite accumulating studies detailing the effects of age on the brain and cognition, the relationship between white matter features and cognitive function in aging have only recently received attention and remain incompletely understood. White matter microstructure can be measured with diffusion tensor imaging (DTI), but whether DTI can provide unique information on brain aging that is not explained by white matter volume is not known. In the current study, the relationship between white matter microstructure, age, and neuropsychological function was assessed using DTI in a statistical framework that employed white matter volume as a voxel-wise covariate in a sample of 120 healthy adults across a broad age range (18-83). Memory function and executive function were modestly correlated with the DTI measures while processing speed showed the greatest extent of correlation. The results suggest that age-related white matter alterations underlie age-related declines in cognitive function. Mean diffusivity and fractional anisotropy in several white matter brain regions exhibited a nonlinear relationship with age, while white matter volume showed a primarily linear relationship with age. The complex relationships between cognition, white matter microstructure, and white matter volume still require further investigation.

Authors+Show Affiliations

Geriatric Research Educational and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin 53705, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

20446132

Citation

Bendlin, Barbara B., et al. "White Matter in Aging and Cognition: a Cross-sectional Study of Microstructure in Adults Aged Eighteen to Eighty-three." Developmental Neuropsychology, vol. 35, no. 3, 2010, pp. 257-77.
Bendlin BB, Fitzgerald ME, Ries ML, et al. White matter in aging and cognition: a cross-sectional study of microstructure in adults aged eighteen to eighty-three. Dev Neuropsychol. 2010;35(3):257-77.
Bendlin, B. B., Fitzgerald, M. E., Ries, M. L., Xu, G., Kastman, E. K., Thiel, B. W., ... Johnson, S. C. (2010). White matter in aging and cognition: a cross-sectional study of microstructure in adults aged eighteen to eighty-three. Developmental Neuropsychology, 35(3), pp. 257-77. doi:10.1080/87565641003696775.
Bendlin BB, et al. White Matter in Aging and Cognition: a Cross-sectional Study of Microstructure in Adults Aged Eighteen to Eighty-three. Dev Neuropsychol. 2010;35(3):257-77. PubMed PMID: 20446132.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - White matter in aging and cognition: a cross-sectional study of microstructure in adults aged eighteen to eighty-three. AU - Bendlin,Barbara B, AU - Fitzgerald,Michele E, AU - Ries,Michele L, AU - Xu,Guofan, AU - Kastman,Erik K, AU - Thiel,Brent W, AU - Rowley,Howard A, AU - Lazar,Mariana, AU - Alexander,Andrew L, AU - Johnson,Sterling C, PY - 2010/5/7/entrez PY - 2010/5/7/pubmed PY - 2010/8/14/medline SP - 257 EP - 77 JF - Developmental neuropsychology JO - Dev Neuropsychol VL - 35 IS - 3 N2 - Structural brain change and concomitant cognitive decline are the seemingly unavoidable escorts of aging. Despite accumulating studies detailing the effects of age on the brain and cognition, the relationship between white matter features and cognitive function in aging have only recently received attention and remain incompletely understood. White matter microstructure can be measured with diffusion tensor imaging (DTI), but whether DTI can provide unique information on brain aging that is not explained by white matter volume is not known. In the current study, the relationship between white matter microstructure, age, and neuropsychological function was assessed using DTI in a statistical framework that employed white matter volume as a voxel-wise covariate in a sample of 120 healthy adults across a broad age range (18-83). Memory function and executive function were modestly correlated with the DTI measures while processing speed showed the greatest extent of correlation. The results suggest that age-related white matter alterations underlie age-related declines in cognitive function. Mean diffusivity and fractional anisotropy in several white matter brain regions exhibited a nonlinear relationship with age, while white matter volume showed a primarily linear relationship with age. The complex relationships between cognition, white matter microstructure, and white matter volume still require further investigation. SN - 1532-6942 UR - https://www.unboundmedicine.com/medline/citation/20446132/White_matter_in_aging_and_cognition:_a_cross_sectional_study_of_microstructure_in_adults_aged_eighteen_to_eighty_three_ L2 - http://www.tandfonline.com/doi/full/10.1080/87565641003696775 DB - PRIME DP - Unbound Medicine ER -