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Neoandrographolide from Andrographis paniculata as a potential natural chemosensitizer.
Planta Med. 2010 Oct; 76(15):1698-700.PM

Abstract

Extracts of the traditional medicinal herb Andrographis paniculata and its main constituents are described in the literature as showing anticancer activity. The aim of this study was to isolate the main constituents of a commercially available phytotherapeutic preparation of A. paniculata and to determine their chemosensitizing potential in a leukemia cell line. Chromatographic separation steps resulted in the isolation of the diterpenes andrographolide (1) and 14-deoxy-11,12-didehydroandrographolide (3) and the diterpene glucoside neoandrographolide (2). The combination of these constituents with suboptimal concentrations of etoposide revealed compound 2 as chemosensitizer in S-Jurkat and X chromosome-linked inhibitor of apoptosis protein (XIAP)-overexpressing Jurkat cells, a model for chemoresistance.

Authors+Show Affiliations

Institute of Pharmacy/Pharmacognosy, Center for Molecular Biosciences Innsbruck, Leopold-Franzens University of Innsbruck, Innsbruck, Austria.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20446243

Citation

Pfisterer, Petra H., et al. "Neoandrographolide From Andrographis Paniculata as a Potential Natural Chemosensitizer." Planta Medica, vol. 76, no. 15, 2010, pp. 1698-700.
Pfisterer PH, Rollinger JM, Schyschka L, et al. Neoandrographolide from Andrographis paniculata as a potential natural chemosensitizer. Planta Med. 2010;76(15):1698-700.
Pfisterer, P. H., Rollinger, J. M., Schyschka, L., Rudy, A., Vollmar, A. M., & Stuppner, H. (2010). Neoandrographolide from Andrographis paniculata as a potential natural chemosensitizer. Planta Medica, 76(15), 1698-700. https://doi.org/10.1055/s-0030-1249876
Pfisterer PH, et al. Neoandrographolide From Andrographis Paniculata as a Potential Natural Chemosensitizer. Planta Med. 2010;76(15):1698-700. PubMed PMID: 20446243.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neoandrographolide from Andrographis paniculata as a potential natural chemosensitizer. AU - Pfisterer,Petra H, AU - Rollinger,Judith M, AU - Schyschka,Lilianna, AU - Rudy,Anita, AU - Vollmar,Angelika M, AU - Stuppner,Hermann, Y1 - 2010/05/05/ PY - 2010/5/7/entrez PY - 2010/5/7/pubmed PY - 2011/4/16/medline SP - 1698 EP - 700 JF - Planta medica JO - Planta Med VL - 76 IS - 15 N2 - Extracts of the traditional medicinal herb Andrographis paniculata and its main constituents are described in the literature as showing anticancer activity. The aim of this study was to isolate the main constituents of a commercially available phytotherapeutic preparation of A. paniculata and to determine their chemosensitizing potential in a leukemia cell line. Chromatographic separation steps resulted in the isolation of the diterpenes andrographolide (1) and 14-deoxy-11,12-didehydroandrographolide (3) and the diterpene glucoside neoandrographolide (2). The combination of these constituents with suboptimal concentrations of etoposide revealed compound 2 as chemosensitizer in S-Jurkat and X chromosome-linked inhibitor of apoptosis protein (XIAP)-overexpressing Jurkat cells, a model for chemoresistance. SN - 1439-0221 UR - https://www.unboundmedicine.com/medline/citation/20446243/Neoandrographolide_from_Andrographis_paniculata_as_a_potential_natural_chemosensitizer_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0030-1249876 DB - PRIME DP - Unbound Medicine ER -