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Protection of Monascus-fermented dioscorea against DMBA-induced oral injury in hamster by anti-inflammatory and antioxidative potentials.
J Agric Food Chem. 2010 Jun 09; 58(11):6715-20.JA

Abstract

Monascus -fermented products offer valuable therapeutic benefits and have been extensively used in East Asia. This study investigated the prevention of oral tumor formation and antioxidative ability of the ethanol extracts from red mold dioscorea (RMDE) on 7,12-dimethyl-1,2-benz[a]anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinogenesis. The HBP was painted with DMBA three times per week for 14 weeks, and animals were painted with celecoxib, RMDE (50, 100, and 200 mg/kg of bw), and ethanol extracts from dioscorea (200 mg/kg of bw) on days alternate to the DMBA application. The results demonstrated that RMDE attenuated tumor formation by elevating the antioxidase activity and suppressing the overproduction of reactive oxygen species, nitric oxide, prostaglandin E(2), and pro-inflammatory cytokines in the HBP caused by DMBA induction. These results indicated that RMDE exerted anti-inflammatory and antioxidative activity to prevent oral cancer. Therefore, the metabolite from Monascus fermentation may serve as a possible functional edible substance for the prevention of oral cancer.

Authors+Show Affiliations

Institute of Microbiology and Biochemistry, College of Life Science, National Taiwan University, No 1, Sec 4, Roosevelt Road, Taipei, Taiwan.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20446737

Citation

Hsu, Wei-Hsuan, et al. "Protection of Monascus-fermented Dioscorea Against DMBA-induced Oral Injury in Hamster By Anti-inflammatory and Antioxidative Potentials." Journal of Agricultural and Food Chemistry, vol. 58, no. 11, 2010, pp. 6715-20.
Hsu WH, Lee BH, Pan TM. Protection of Monascus-fermented dioscorea against DMBA-induced oral injury in hamster by anti-inflammatory and antioxidative potentials. J Agric Food Chem. 2010;58(11):6715-20.
Hsu, W. H., Lee, B. H., & Pan, T. M. (2010). Protection of Monascus-fermented dioscorea against DMBA-induced oral injury in hamster by anti-inflammatory and antioxidative potentials. Journal of Agricultural and Food Chemistry, 58(11), 6715-20. https://doi.org/10.1021/jf100889w
Hsu WH, Lee BH, Pan TM. Protection of Monascus-fermented Dioscorea Against DMBA-induced Oral Injury in Hamster By Anti-inflammatory and Antioxidative Potentials. J Agric Food Chem. 2010 Jun 9;58(11):6715-20. PubMed PMID: 20446737.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protection of Monascus-fermented dioscorea against DMBA-induced oral injury in hamster by anti-inflammatory and antioxidative potentials. AU - Hsu,Wei-Hsuan, AU - Lee,Bao-Hong, AU - Pan,Tzu-Ming, PY - 2010/5/8/entrez PY - 2010/5/8/pubmed PY - 2010/8/28/medline SP - 6715 EP - 20 JF - Journal of agricultural and food chemistry JO - J. Agric. Food Chem. VL - 58 IS - 11 N2 - Monascus -fermented products offer valuable therapeutic benefits and have been extensively used in East Asia. This study investigated the prevention of oral tumor formation and antioxidative ability of the ethanol extracts from red mold dioscorea (RMDE) on 7,12-dimethyl-1,2-benz[a]anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinogenesis. The HBP was painted with DMBA three times per week for 14 weeks, and animals were painted with celecoxib, RMDE (50, 100, and 200 mg/kg of bw), and ethanol extracts from dioscorea (200 mg/kg of bw) on days alternate to the DMBA application. The results demonstrated that RMDE attenuated tumor formation by elevating the antioxidase activity and suppressing the overproduction of reactive oxygen species, nitric oxide, prostaglandin E(2), and pro-inflammatory cytokines in the HBP caused by DMBA induction. These results indicated that RMDE exerted anti-inflammatory and antioxidative activity to prevent oral cancer. Therefore, the metabolite from Monascus fermentation may serve as a possible functional edible substance for the prevention of oral cancer. SN - 1520-5118 UR - https://www.unboundmedicine.com/medline/citation/20446737/Protection_of_Monascus_fermented_dioscorea_against_DMBA_induced_oral_injury_in_hamster_by_anti_inflammatory_and_antioxidative_potentials_ L2 - https://dx.doi.org/10.1021/jf100889w DB - PRIME DP - Unbound Medicine ER -