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Neurobehavioral effects of acute exposure to aromatic hydrocarbons.
Int J Toxicol. 2010 May-Jun; 29(3):277-90.IJ

Abstract

This article reports the results of neurobehavioral tests on representative aromatic constituents, specifically C(9) to C(11) species. The testing evaluated effects in several domains including clinical effects, motor activity, functional observations, and visual discrimination performance. Exposures ranging from 600 to 5000 mg/m(3), depending on the molecular weights of the specific aromatic constituents, produced minor, reversible effects on the central nervous system (CNS), particularly in the domains of gait and visual discrimination. There was little evidence of effects at lower exposure levels. There was some evidence of respiratory effects at 5000 mg/m(3) in 1 study, and there were also minor changes in body weight and temperature. The CNS effects became less pronounced with repeated exposures, corresponding to lower concentrations in the brain of 1 representative substance, 1,2,4-trimethyl benzene (TMB). At high exposure levels, the alkyl benzenes apparently induced their own metabolism, increasing elimination rates.

Authors+Show Affiliations

ExxonMobil Biomedical Sciences, Inc., 1545 Route 22 East, Annandale, NJ 08801, USA. richard.h.mckee@exxonmobil.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20448260

Citation

McKee, Richard H., et al. "Neurobehavioral Effects of Acute Exposure to Aromatic Hydrocarbons." International Journal of Toxicology, vol. 29, no. 3, 2010, pp. 277-90.
McKee RH, Lammers JH, Muijser H, et al. Neurobehavioral effects of acute exposure to aromatic hydrocarbons. Int J Toxicol. 2010;29(3):277-90.
McKee, R. H., Lammers, J. H., Muijser, H., Owen, D. E., & Kulig, B. M. (2010). Neurobehavioral effects of acute exposure to aromatic hydrocarbons. International Journal of Toxicology, 29(3), 277-90. https://doi.org/10.1177/1091581810365089
McKee RH, et al. Neurobehavioral Effects of Acute Exposure to Aromatic Hydrocarbons. Int J Toxicol. 2010 May-Jun;29(3):277-90. PubMed PMID: 20448260.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurobehavioral effects of acute exposure to aromatic hydrocarbons. AU - McKee,Richard H, AU - Lammers,J H C M, AU - Muijser,H, AU - Owen,D E, AU - Kulig,B M, PY - 2010/5/8/entrez PY - 2010/5/8/pubmed PY - 2010/8/28/medline SP - 277 EP - 90 JF - International journal of toxicology JO - Int J Toxicol VL - 29 IS - 3 N2 - This article reports the results of neurobehavioral tests on representative aromatic constituents, specifically C(9) to C(11) species. The testing evaluated effects in several domains including clinical effects, motor activity, functional observations, and visual discrimination performance. Exposures ranging from 600 to 5000 mg/m(3), depending on the molecular weights of the specific aromatic constituents, produced minor, reversible effects on the central nervous system (CNS), particularly in the domains of gait and visual discrimination. There was little evidence of effects at lower exposure levels. There was some evidence of respiratory effects at 5000 mg/m(3) in 1 study, and there were also minor changes in body weight and temperature. The CNS effects became less pronounced with repeated exposures, corresponding to lower concentrations in the brain of 1 representative substance, 1,2,4-trimethyl benzene (TMB). At high exposure levels, the alkyl benzenes apparently induced their own metabolism, increasing elimination rates. SN - 1092-874X UR - https://www.unboundmedicine.com/medline/citation/20448260/Neurobehavioral_effects_of_acute_exposure_to_aromatic_hydrocarbons_ L2 - https://journals.sagepub.com/doi/10.1177/1091581810365089?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -