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Dorsal raphe nucleus regulation of a panic-like defensive behavior evoked by chemical stimulation of the rat dorsal periaqueductal gray matter.
Behav Brain Res. 2010 Dec 01; 213(2):195-200.BB

Abstract

Electrical or chemical stimulation of the dorsal periaqueductal gray matter (DPAG) evokes escape, a defensive behavior that has been related to panic attacks. Injection of 5-HT(1A) or 5-HT(2A) receptor agonists into this midbrain area inhibits this response. It has been proposed that the impairment of 5-HT mechanisms controlling escape at the level of the DPAG may underlie the susceptibility to panic attacks that characterizes the panic disorder. In this study we evaluated the effects of the pharmacological manipulation of the dorsal raphe nucleus (DRN), which are the main source of 5-HT input to the DPAG, on the escape response evoked in rats by the intra-DPAG injection of the nitric oxide donor SIN-1. The results showed that DRN administration of the 5-HT(1A) receptor agonist 8-OH-DPAT which inhibits the activity of 5-HT neurons favored the expression of escape induced by SIN-1. Intra-DRN injection of the excitatory amino acid kainic acid or the 5-HT(1A) receptor antagonist WAY-100635 did not change escape expression. However, both compounds fully blocked the escape reaction generated by intra-DPAG injection of the excitatory amino acid d,l-homocysteic acid (DLH). Overall, the results indicate that 5-HT neurons in the DRN exert a bidirectional control upon escape behavior generated by the DPAG. Taking into account the effect of WAY-100635 on DLH-induced escape, they also strengthen the view that DRN 5-HT(1A) autoreceptors are under tonic inhibitory influence by 5-HT.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Miguel TL
Department of Pharmacology, School of Medicine, University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto, CEP, Brazil.
Pobbe RL
No affiliation info available
Spiacci Junior A
No affiliation info available
Zangrossi Junior H
No affiliation info available

MeSH

8-Hydroxy-2-(di-n-propylamino)tetralinAnimalsDisease Models, AnimalEscape ReactionHomocysteineKainic AcidMaleMolsidominePanic DisorderPeriaqueductal GrayPiperazinesPyridinesRaphe NucleiRatsRats, WistarSerotonin 5-HT1 Receptor AgonistsSerotonin 5-HT1 Receptor Antagonists

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20451559

Citation

Miguel, Tatiana Longo Borges, et al. "Dorsal Raphe Nucleus Regulation of a Panic-like Defensive Behavior Evoked By Chemical Stimulation of the Rat Dorsal Periaqueductal Gray Matter." Behavioural Brain Research, vol. 213, no. 2, 2010, pp. 195-200.
Miguel TL, Pobbe RL, Spiacci Junior A, et al. Dorsal raphe nucleus regulation of a panic-like defensive behavior evoked by chemical stimulation of the rat dorsal periaqueductal gray matter. Behav Brain Res. 2010;213(2):195-200.
Miguel, T. L., Pobbe, R. L., Spiacci Junior, A., & Zangrossi Junior, H. (2010). Dorsal raphe nucleus regulation of a panic-like defensive behavior evoked by chemical stimulation of the rat dorsal periaqueductal gray matter. Behavioural Brain Research, 213(2), 195-200. https://doi.org/10.1016/j.bbr.2010.04.055
Miguel TL, et al. Dorsal Raphe Nucleus Regulation of a Panic-like Defensive Behavior Evoked By Chemical Stimulation of the Rat Dorsal Periaqueductal Gray Matter. Behav Brain Res. 2010 Dec 1;213(2):195-200. PubMed PMID: 20451559.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dorsal raphe nucleus regulation of a panic-like defensive behavior evoked by chemical stimulation of the rat dorsal periaqueductal gray matter. AU - Miguel,Tatiana Longo Borges, AU - Pobbe,Roger Luis Henschel, AU - Spiacci Junior,Ailton, AU - Zangrossi Junior,Hélio, Y1 - 2010/05/06/ PY - 2010/03/18/received PY - 2010/04/26/revised PY - 2010/04/29/accepted PY - 2010/5/11/entrez PY - 2010/5/11/pubmed PY - 2010/10/20/medline SP - 195 EP - 200 JF - Behavioural brain research JO - Behav Brain Res VL - 213 IS - 2 N2 - Electrical or chemical stimulation of the dorsal periaqueductal gray matter (DPAG) evokes escape, a defensive behavior that has been related to panic attacks. Injection of 5-HT(1A) or 5-HT(2A) receptor agonists into this midbrain area inhibits this response. It has been proposed that the impairment of 5-HT mechanisms controlling escape at the level of the DPAG may underlie the susceptibility to panic attacks that characterizes the panic disorder. In this study we evaluated the effects of the pharmacological manipulation of the dorsal raphe nucleus (DRN), which are the main source of 5-HT input to the DPAG, on the escape response evoked in rats by the intra-DPAG injection of the nitric oxide donor SIN-1. The results showed that DRN administration of the 5-HT(1A) receptor agonist 8-OH-DPAT which inhibits the activity of 5-HT neurons favored the expression of escape induced by SIN-1. Intra-DRN injection of the excitatory amino acid kainic acid or the 5-HT(1A) receptor antagonist WAY-100635 did not change escape expression. However, both compounds fully blocked the escape reaction generated by intra-DPAG injection of the excitatory amino acid d,l-homocysteic acid (DLH). Overall, the results indicate that 5-HT neurons in the DRN exert a bidirectional control upon escape behavior generated by the DPAG. Taking into account the effect of WAY-100635 on DLH-induced escape, they also strengthen the view that DRN 5-HT(1A) autoreceptors are under tonic inhibitory influence by 5-HT. SN - 1872-7549 UR - https://www.unboundmedicine.com/medline/citation/20451559/Dorsal_raphe_nucleus_regulation_of_a_panic_like_defensive_behavior_evoked_by_chemical_stimulation_of_the_rat_dorsal_periaqueductal_gray_matter_ DB - PRIME DP - Unbound Medicine ER -