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Patterns of tooth agenesis in patients with Down syndrome in relation to hypothyroidism and congenital heart disease: an aid for treatment planning.
Am J Orthod Dentofacial Orthop. 2010 May; 137(5):584.e1-9; discussion 584-5.AJ

Abstract

INTRODUCTION

The purposes of this study were to investigate the patterns of tooth agenesis (oligodontia and nonoligodontia), maxillary canine impaction, and tooth transposition in subjects with Down syndrome and to determine whether congenital heart disease and hypothyroidism are parameters in tooth agenesis.

METHODS

The study included 114 patients with Down syndrome. The data were quantified by using standardized records, clinical examinations, panoramic radiographs, and solo roentgenograms. The subjects were differentiated into oligodontia (6 or more teeth missing) and nonoligodontia (5 or fewer teeth missing).

RESULTS

In these patients with Down syndrome, 59.6% had missing teeth. Those in the nonoligodontia group showed a tendency toward a negative correlation between congenital heart disease and agenesis (P = 0.093; odds ratio = 0.49) but a slight positive correlation between hypothyroidism and agenesis (P = 0.060; odds ratio = 3.71). In the oligodontia group, there was a quantitatively and qualitatively different pattern, indicating another phenotype. When both mandibular central incisors were missing, there was a remarkable chance for oligodontia (P = 0.001; odds ratio = 38.8). In the mandible, symmetrical agenesis of the canines and lateral incisors was more frequent in the nonoligodontia group.

CONCLUSIONS

The oligodontia (with a different phenotype) and nonoligodontia groups had different patterns of agenesis. Maxillary canine impaction was not related to absence of the lateral incisors. Absence of both mandibular central incisors was a high predictor for oligodontia. Congenital heart disease and hypothyroidism are parameters involved in tooth agenesis.

Authors+Show Affiliations

Dentist, Centre for Special Care Dentistry, CBT Rijnmond, Rotterdam, The Netherlands. wimke@reuland.nlNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20451772

Citation

Reuland-Bosma, Wimke, et al. "Patterns of Tooth Agenesis in Patients With Down Syndrome in Relation to Hypothyroidism and Congenital Heart Disease: an Aid for Treatment Planning." American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics, vol. 137, no. 5, 2010, pp. 584.e1-9; discussion 584-5.
Reuland-Bosma W, Reuland MC, Bronkhorst E, et al. Patterns of tooth agenesis in patients with Down syndrome in relation to hypothyroidism and congenital heart disease: an aid for treatment planning. Am J Orthod Dentofacial Orthop. 2010;137(5):584.e1-9; discussion 584-5.
Reuland-Bosma, W., Reuland, M. C., Bronkhorst, E., & Phoa, K. H. (2010). Patterns of tooth agenesis in patients with Down syndrome in relation to hypothyroidism and congenital heart disease: an aid for treatment planning. American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics, 137(5), e1-9; discussion 584-5. https://doi.org/10.1016/j.ajodo.2009.10.032
Reuland-Bosma W, et al. Patterns of Tooth Agenesis in Patients With Down Syndrome in Relation to Hypothyroidism and Congenital Heart Disease: an Aid for Treatment Planning. Am J Orthod Dentofacial Orthop. 2010;137(5):584.e1-9; discussion 584-5. PubMed PMID: 20451772.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Patterns of tooth agenesis in patients with Down syndrome in relation to hypothyroidism and congenital heart disease: an aid for treatment planning. AU - Reuland-Bosma,Wimke, AU - Reuland,Merijn C, AU - Bronkhorst,Ewald, AU - Phoa,Khee Hian, PY - 2009/07/01/received PY - 2009/10/01/revised PY - 2009/10/01/accepted PY - 2010/5/11/entrez PY - 2010/5/11/pubmed PY - 2010/7/14/medline SP - 584.e1-9; discussion 584-5 JF - American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics JO - Am J Orthod Dentofacial Orthop VL - 137 IS - 5 N2 - INTRODUCTION: The purposes of this study were to investigate the patterns of tooth agenesis (oligodontia and nonoligodontia), maxillary canine impaction, and tooth transposition in subjects with Down syndrome and to determine whether congenital heart disease and hypothyroidism are parameters in tooth agenesis. METHODS: The study included 114 patients with Down syndrome. The data were quantified by using standardized records, clinical examinations, panoramic radiographs, and solo roentgenograms. The subjects were differentiated into oligodontia (6 or more teeth missing) and nonoligodontia (5 or fewer teeth missing). RESULTS: In these patients with Down syndrome, 59.6% had missing teeth. Those in the nonoligodontia group showed a tendency toward a negative correlation between congenital heart disease and agenesis (P = 0.093; odds ratio = 0.49) but a slight positive correlation between hypothyroidism and agenesis (P = 0.060; odds ratio = 3.71). In the oligodontia group, there was a quantitatively and qualitatively different pattern, indicating another phenotype. When both mandibular central incisors were missing, there was a remarkable chance for oligodontia (P = 0.001; odds ratio = 38.8). In the mandible, symmetrical agenesis of the canines and lateral incisors was more frequent in the nonoligodontia group. CONCLUSIONS: The oligodontia (with a different phenotype) and nonoligodontia groups had different patterns of agenesis. Maxillary canine impaction was not related to absence of the lateral incisors. Absence of both mandibular central incisors was a high predictor for oligodontia. Congenital heart disease and hypothyroidism are parameters involved in tooth agenesis. SN - 1097-6752 UR - https://www.unboundmedicine.com/medline/citation/20451772/Patterns_of_tooth_agenesis_in_patients_with_Down_syndrome_in_relation_to_hypothyroidism_and_congenital_heart_disease:_an_aid_for_treatment_planning_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0889-5406(10)00021-1 DB - PRIME DP - Unbound Medicine ER -