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Cholesterol, CSF 5-HIAA, violence and intent in suicidal men.
Psychiatry Res. 2010 Jun 30; 178(1):217-9.PR

Abstract

Associations between suicide, violent behaviour and both hypocholesterolaemia and low 5-hydroxyindolacetic acid (5-HIAA) in the cerebrospinal fluid (CSF) have been suggested. The relationships between lipids, the serotonergic system, suicidal and aggressive behaviors are complex. We explored relationships between serum cholesterol, CSF 5-HIAA, the planning subscale of suicide intent and violence of attempted suicide method in 13 medication-free male suicide attempters and eight healthy volunteers. Serum high-density lipoprotein cholesterol (HDL-C) levels were significantly lower in suicide attempters than in controls. HDL-C showed a significant positive correlation with the planning subscale of suicide intent in non-violent suicide attempters. A positive association was observed between CSF 5-HIAA and serum cholesterol in suicides. The role of cholesterol may be different in planned non-violent suicide attempts compared with violent suicide attempts.

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Authors+Show Affiliations

Jokinen J
Department of Clinical Neuroscience/Psychiatry, Karolinska Institutet, Karolinska University Hospital, Solna, Stockholm, Sweden. jussi.jokinen@ki.se
Nordström AL
No affiliation info available
Nordström P
No affiliation info available

MeSH

CholesterolHumansHydroxyindoleacetic AcidLipoproteinsMaleMass SpectrometryPsychiatric Status Rating ScalesRetrospective StudiesSuicideSuicide, AttemptedViolence

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20452040

Citation

Jokinen, Jussi, et al. "Cholesterol, CSF 5-HIAA, Violence and Intent in Suicidal Men." Psychiatry Research, vol. 178, no. 1, 2010, pp. 217-9.
Jokinen J, Nordström AL, Nordström P. Cholesterol, CSF 5-HIAA, violence and intent in suicidal men. Psychiatry Res. 2010;178(1):217-9.
Jokinen, J., Nordström, A. L., & Nordström, P. (2010). Cholesterol, CSF 5-HIAA, violence and intent in suicidal men. Psychiatry Research, 178(1), 217-9. https://doi.org/10.1016/j.psychres.2008.07.020
Jokinen J, Nordström AL, Nordström P. Cholesterol, CSF 5-HIAA, Violence and Intent in Suicidal Men. Psychiatry Res. 2010 Jun 30;178(1):217-9. PubMed PMID: 20452040.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cholesterol, CSF 5-HIAA, violence and intent in suicidal men. AU - Jokinen,Jussi, AU - Nordström,Anna-Lena, AU - Nordström,Peter, Y1 - 2010/05/08/ PY - 2008/01/16/received PY - 2008/04/19/revised PY - 2008/07/31/accepted PY - 2010/5/11/entrez PY - 2010/5/11/pubmed PY - 2014/6/4/medline SP - 217 EP - 9 JF - Psychiatry research JO - Psychiatry Res VL - 178 IS - 1 N2 - Associations between suicide, violent behaviour and both hypocholesterolaemia and low 5-hydroxyindolacetic acid (5-HIAA) in the cerebrospinal fluid (CSF) have been suggested. The relationships between lipids, the serotonergic system, suicidal and aggressive behaviors are complex. We explored relationships between serum cholesterol, CSF 5-HIAA, the planning subscale of suicide intent and violence of attempted suicide method in 13 medication-free male suicide attempters and eight healthy volunteers. Serum high-density lipoprotein cholesterol (HDL-C) levels were significantly lower in suicide attempters than in controls. HDL-C showed a significant positive correlation with the planning subscale of suicide intent in non-violent suicide attempters. A positive association was observed between CSF 5-HIAA and serum cholesterol in suicides. The role of cholesterol may be different in planned non-violent suicide attempts compared with violent suicide attempts. SN - 0165-1781 UR - https://www.unboundmedicine.com/medline/citation/20452040/Cholesterol_CSF_5_HIAA_violence_and_intent_in_suicidal_men_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-1781(08)00248-5 DB - PRIME DP - Unbound Medicine ER -