Tags

Type your tag names separated by a space and hit enter

Oxidative stress, extracellular matrix targets, and idiopathic pulmonary fibrosis.
Free Radic Biol Med 2010; 49(5):707-17FR

Abstract

Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterized by progressive fibrosis of the alveolar interstitium. The pathogenesis is thought to involve abnormal reepithelialization and dysregulated remodeling of the extracellular matrix after alveolar injury. There is growing evidence through human and animal studies that oxidative stress plays a role in this dysregulation. Markers of oxidative stress have been identified in the lungs of IPF patients and aberrant antioxidant activity exacerbates pulmonary fibrosis in animal models. In addition, the extracellular matrix is a critical component in regulating cellular homeostasis and appropriate wound healing. Recent investigations support that the matrix is a target of oxidative stress in the lung and IPF. Extracellular matrix degradation products, produced by reactive oxygen species, may promote fibrogenesis by influencing epithelial, mesenchymal, and inflammatory cell activity. The impact of the interactions of oxidative stress and the matrix of the lung remains unclear and may prove to be an important target for new therapies in IPF. Utilizing oxidative enzymes, antioxidants, or the matrix as therapeutic targets to control oxidative stress in IPF will continue be an area of active research and innovative discoveries in the coming years.

Authors+Show Affiliations

Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20452419

Citation

Kliment, Corrine R., and Tim D. Oury. "Oxidative Stress, Extracellular Matrix Targets, and Idiopathic Pulmonary Fibrosis." Free Radical Biology & Medicine, vol. 49, no. 5, 2010, pp. 707-17.
Kliment CR, Oury TD. Oxidative stress, extracellular matrix targets, and idiopathic pulmonary fibrosis. Free Radic Biol Med. 2010;49(5):707-17.
Kliment, C. R., & Oury, T. D. (2010). Oxidative stress, extracellular matrix targets, and idiopathic pulmonary fibrosis. Free Radical Biology & Medicine, 49(5), pp. 707-17. doi:10.1016/j.freeradbiomed.2010.04.036.
Kliment CR, Oury TD. Oxidative Stress, Extracellular Matrix Targets, and Idiopathic Pulmonary Fibrosis. Free Radic Biol Med. 2010 Sep 1;49(5):707-17. PubMed PMID: 20452419.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidative stress, extracellular matrix targets, and idiopathic pulmonary fibrosis. AU - Kliment,Corrine R, AU - Oury,Tim D, Y1 - 2010/05/07/ PY - 2009/12/19/received PY - 2010/04/27/revised PY - 2010/04/29/accepted PY - 2010/5/11/entrez PY - 2010/5/11/pubmed PY - 2010/12/16/medline SP - 707 EP - 17 JF - Free radical biology & medicine JO - Free Radic. Biol. Med. VL - 49 IS - 5 N2 - Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterized by progressive fibrosis of the alveolar interstitium. The pathogenesis is thought to involve abnormal reepithelialization and dysregulated remodeling of the extracellular matrix after alveolar injury. There is growing evidence through human and animal studies that oxidative stress plays a role in this dysregulation. Markers of oxidative stress have been identified in the lungs of IPF patients and aberrant antioxidant activity exacerbates pulmonary fibrosis in animal models. In addition, the extracellular matrix is a critical component in regulating cellular homeostasis and appropriate wound healing. Recent investigations support that the matrix is a target of oxidative stress in the lung and IPF. Extracellular matrix degradation products, produced by reactive oxygen species, may promote fibrogenesis by influencing epithelial, mesenchymal, and inflammatory cell activity. The impact of the interactions of oxidative stress and the matrix of the lung remains unclear and may prove to be an important target for new therapies in IPF. Utilizing oxidative enzymes, antioxidants, or the matrix as therapeutic targets to control oxidative stress in IPF will continue be an area of active research and innovative discoveries in the coming years. SN - 1873-4596 UR - https://www.unboundmedicine.com/medline/citation/20452419/Oxidative_stress_extracellular_matrix_targets_and_idiopathic_pulmonary_fibrosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0891-5849(10)00282-0 DB - PRIME DP - Unbound Medicine ER -