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A meta-analytic review of polyunsaturated fatty acid compositions in patients with depression.
Biol Psychiatry. 2010 Jul 15; 68(2):140-7.BP

Abstract

BACKGROUND

On the basis of evidence from studies showing the antidepressant effects of omega-3 polyunsaturated fatty acids and the inverse relation between fish consumption and the prevalence of depression, the phospholipid hypothesis seems promising in ascertaining the etiology and treatment of depression. Although several studies have shown lower levels of omega-3 (n-3) polyunsaturated fatty acids in depressive patients, the results of individual polyunsaturated fatty acids, including docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and the omega-6 (n-6) polyunsaturated fatty acid arachidonic acid (AA), were inconsistent.

METHODS

We conducted the meta-analyses of 14 studies comparing the levels of polyunsaturated fatty acids between depressive patients and control subjects. The effect size of each study was synthesized by using a random effects model.

RESULTS

Compared with control subjects, the levels of EPA, DHA, and total n-3 polyunsaturated fatty acids were significantly lower in depressive patients. There was no significant change in AA or total n-6 polyunsaturated fatty acids.

CONCLUSIONS

The results showed lower levels of EPA, DHA, and total n-3 polyunsaturated fatty acids in patients with depression, thus implying that n-3 polyunsaturated fatty acids play a role in the pathogenesis of depression. Our findings provide further support to the phospholipid hypothesis of depression and a rationale for using n-3 polyunsaturated fatty acids as an alternative treatment for depression. With these results, future studies examining specific roles of DHA and EPA in different clusters of depressive symptoms are warranted.

Authors+Show Affiliations

Department of Psychiatry, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20452573

Citation

Lin, Pao-Yen, et al. "A Meta-analytic Review of Polyunsaturated Fatty Acid Compositions in Patients With Depression." Biological Psychiatry, vol. 68, no. 2, 2010, pp. 140-7.
Lin PY, Huang SY, Su KP. A meta-analytic review of polyunsaturated fatty acid compositions in patients with depression. Biol Psychiatry. 2010;68(2):140-7.
Lin, P. Y., Huang, S. Y., & Su, K. P. (2010). A meta-analytic review of polyunsaturated fatty acid compositions in patients with depression. Biological Psychiatry, 68(2), 140-7. https://doi.org/10.1016/j.biopsych.2010.03.018
Lin PY, Huang SY, Su KP. A Meta-analytic Review of Polyunsaturated Fatty Acid Compositions in Patients With Depression. Biol Psychiatry. 2010 Jul 15;68(2):140-7. PubMed PMID: 20452573.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A meta-analytic review of polyunsaturated fatty acid compositions in patients with depression. AU - Lin,Pao-Yen, AU - Huang,Shih-Yi, AU - Su,Kuan-Pin, Y1 - 2010/05/10/ PY - 2009/10/06/received PY - 2010/03/09/revised PY - 2010/03/10/accepted PY - 2010/5/11/entrez PY - 2010/5/11/pubmed PY - 2010/10/13/medline SP - 140 EP - 7 JF - Biological psychiatry JO - Biol Psychiatry VL - 68 IS - 2 N2 - BACKGROUND: On the basis of evidence from studies showing the antidepressant effects of omega-3 polyunsaturated fatty acids and the inverse relation between fish consumption and the prevalence of depression, the phospholipid hypothesis seems promising in ascertaining the etiology and treatment of depression. Although several studies have shown lower levels of omega-3 (n-3) polyunsaturated fatty acids in depressive patients, the results of individual polyunsaturated fatty acids, including docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and the omega-6 (n-6) polyunsaturated fatty acid arachidonic acid (AA), were inconsistent. METHODS: We conducted the meta-analyses of 14 studies comparing the levels of polyunsaturated fatty acids between depressive patients and control subjects. The effect size of each study was synthesized by using a random effects model. RESULTS: Compared with control subjects, the levels of EPA, DHA, and total n-3 polyunsaturated fatty acids were significantly lower in depressive patients. There was no significant change in AA or total n-6 polyunsaturated fatty acids. CONCLUSIONS: The results showed lower levels of EPA, DHA, and total n-3 polyunsaturated fatty acids in patients with depression, thus implying that n-3 polyunsaturated fatty acids play a role in the pathogenesis of depression. Our findings provide further support to the phospholipid hypothesis of depression and a rationale for using n-3 polyunsaturated fatty acids as an alternative treatment for depression. With these results, future studies examining specific roles of DHA and EPA in different clusters of depressive symptoms are warranted. SN - 1873-2402 UR - https://www.unboundmedicine.com/medline/citation/20452573/A_meta_analytic_review_of_polyunsaturated_fatty_acid_compositions_in_patients_with_depression_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-3223(10)00247-7 DB - PRIME DP - Unbound Medicine ER -