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Available carbohydrates, glycemic load, and pancreatic cancer: is there a link?
Am J Epidemiol 2010; 171(11):1174-82AJ

Abstract

High-carbohydrate diets have been linked to pancreatic cancer risk in case-control studies, but prospective studies have shown mostly null results. The authors investigated the associations of glycemic load, glycemic index, and carbohydrate intake with pancreatic cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Dietary intake was assessed by using a self-administered questionnaire. Between 1998 and 2006 (median follow-up = 6.5 years), 266 incident, confirmed pancreatic cancers were identified among 109,175 participants. Hazards ratios and 95% confidence intervals were adjusted for sex, smoking, body mass index, and total energy. Overall, elevated risks for pancreatic cancer were observed in the 90th versus 10th percentile of glycemic load (hazards ratio (HR) = 1.45, 95% confidence interval (CI): 1.05, 2.00), available carbohydrate (HR = 1.47, 95% CI: 1.05, 2.06), and sucrose (HR = 1.37, 95% CI: 0.99, 1.89) intake. The positive association for available carbohydrate intake was observed during the first 4 years of follow-up (HR(<2 years) = 2.60, 95% CI: 1.34, 5.06; HR(2-<4 years) = 1.94, 95% CI: 1.06, 3.55) but not subsequently (HR = 0.86, 95% CI: 0.52, 1.44); the opposite pattern was observed for total fat and saturated fat intake. Rather than being causal, the short-term increase in pancreatic cancer risk associated with high available carbohydrate and low fat intake may be capturing dietary changes associated with subclinical disease.

Authors+Show Affiliations

National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20452999

Citation

Meinhold, Cari L., et al. "Available Carbohydrates, Glycemic Load, and Pancreatic Cancer: Is There a Link?" American Journal of Epidemiology, vol. 171, no. 11, 2010, pp. 1174-82.
Meinhold CL, Dodd KW, Jiao L, et al. Available carbohydrates, glycemic load, and pancreatic cancer: is there a link? Am J Epidemiol. 2010;171(11):1174-82.
Meinhold, C. L., Dodd, K. W., Jiao, L., Flood, A., Shikany, J. M., Genkinger, J. M., ... Stolzenberg-Solomon, R. Z. (2010). Available carbohydrates, glycemic load, and pancreatic cancer: is there a link? American Journal of Epidemiology, 171(11), pp. 1174-82. doi:10.1093/aje/kwq061.
Meinhold CL, et al. Available Carbohydrates, Glycemic Load, and Pancreatic Cancer: Is There a Link. Am J Epidemiol. 2010 Jun 1;171(11):1174-82. PubMed PMID: 20452999.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Available carbohydrates, glycemic load, and pancreatic cancer: is there a link? AU - Meinhold,Cari L, AU - Dodd,Kevin W, AU - Jiao,Li, AU - Flood,Andrew, AU - Shikany,James M, AU - Genkinger,Jeanine M, AU - Hayes,Richard B, AU - Stolzenberg-Solomon,Rachael Z, Y1 - 2010/05/07/ PY - 2010/5/11/entrez PY - 2010/5/11/pubmed PY - 2010/6/12/medline SP - 1174 EP - 82 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 171 IS - 11 N2 - High-carbohydrate diets have been linked to pancreatic cancer risk in case-control studies, but prospective studies have shown mostly null results. The authors investigated the associations of glycemic load, glycemic index, and carbohydrate intake with pancreatic cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Dietary intake was assessed by using a self-administered questionnaire. Between 1998 and 2006 (median follow-up = 6.5 years), 266 incident, confirmed pancreatic cancers were identified among 109,175 participants. Hazards ratios and 95% confidence intervals were adjusted for sex, smoking, body mass index, and total energy. Overall, elevated risks for pancreatic cancer were observed in the 90th versus 10th percentile of glycemic load (hazards ratio (HR) = 1.45, 95% confidence interval (CI): 1.05, 2.00), available carbohydrate (HR = 1.47, 95% CI: 1.05, 2.06), and sucrose (HR = 1.37, 95% CI: 0.99, 1.89) intake. The positive association for available carbohydrate intake was observed during the first 4 years of follow-up (HR(<2 years) = 2.60, 95% CI: 1.34, 5.06; HR(2-<4 years) = 1.94, 95% CI: 1.06, 3.55) but not subsequently (HR = 0.86, 95% CI: 0.52, 1.44); the opposite pattern was observed for total fat and saturated fat intake. Rather than being causal, the short-term increase in pancreatic cancer risk associated with high available carbohydrate and low fat intake may be capturing dietary changes associated with subclinical disease. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/20452999/Available_carbohydrates_glycemic_load_and_pancreatic_cancer:_is_there_a_link L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwq061 DB - PRIME DP - Unbound Medicine ER -