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Risk of colon cancer and coffee, tea, and sugar-sweetened soft drink intake: pooled analysis of prospective cohort studies.
J Natl Cancer Inst. 2010 Jun 02; 102(11):771-83.JNCI

Abstract

BACKGROUND

The relationships between coffee, tea, and sugar-sweetened carbonated soft drink consumption and colon cancer risk remain unresolved.

METHODS

We investigated prospectively the association between coffee, tea, and sugar-sweetened carbonated soft drink consumption and colon cancer risk in a pooled analysis of primary data from 13 cohort studies. Among 731 441 participants followed for up to 6-20 years, 5604 incident colon cancer case patients were identified. Study-specific relative risks (RRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models and then pooled using a random-effects model. All statistical tests were two-sided.

RESULTS

Compared with nonconsumers, the pooled multivariable relative risks were 1.07 (95% CI = 0.89 to 1.30, P(trend) = .68) for coffee consumption greater than 1400 g/d (about six 8-oz cups) and 1.28 (95% CI = 1.02 to 1.61, P(trend) = .01) for tea consumption greater than 900 g/d (about four 8-oz cups). For sugar-sweetened carbonated soft drink consumption, the pooled multivariable relative risk comparing consumption greater than 550 g/d (about 18 oz) to nonconsumers was 0.94 (95% CI = 0.66 to 1.32, P(trend) = .91). No statistically significant between-studies heterogeneity was observed for the highest category of each beverage consumed (P > .20). The observed associations did not differ by sex, smoking status, alcohol consumption, body mass index, physical activity, or tumor site (P > .05).

CONCLUSIONS

Drinking coffee or sugar-sweetened carbonated soft drinks was not associated with colon cancer risk. However, a modest positive association with higher tea consumption is possible and requires further study.

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Authors+Show Affiliations

Zhang X
Department of Nutrition, Department of Epidemiology, Harvard School of Public Health, 655 Huntington Ave, Boston, MA 02115, USA. pooling@hsphsun2.harvard.edu
Albanes D
No affiliation info available
Beeson WL
No affiliation info available
van den Brandt PA
No affiliation info available
Buring JE
No affiliation info available
Flood A
No affiliation info available
Freudenheim JL
No affiliation info available
Giovannucci EL
No affiliation info available
Goldbohm RA
No affiliation info available
Jaceldo-Siegl K
No affiliation info available
Jacobs EJ
No affiliation info available
Krogh V
No affiliation info available
Larsson SC
No affiliation info available
Marshall JR
No affiliation info available
McCullough ML
No affiliation info available
Miller AB
No affiliation info available
Robien K
No affiliation info available
Rohan TE
No affiliation info available
Schatzkin A
No affiliation info available
Sieri S
No affiliation info available
Spiegelman D
No affiliation info available
Virtamo J
No affiliation info available
Wolk A
No affiliation info available
Willett WC
No affiliation info available
Zhang SM
No affiliation info available
Smith-Warner SA
No affiliation info available

MeSH

AdultAgedCarbonated BeveragesCoffeeCohort StudiesColonic NeoplasmsConfounding Factors, EpidemiologicDietary SucroseEuropeFeeding BehaviorFemaleHumansMaleMiddle AgedMultivariate AnalysisNorth AmericaProportional Hazards ModelsProspective StudiesRisk AssessmentRisk FactorsSweetening AgentsTea

Pub Type(s)

Comparative Study
Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

20453203

Citation

Zhang, Xuehong, et al. "Risk of Colon Cancer and Coffee, Tea, and Sugar-sweetened Soft Drink Intake: Pooled Analysis of Prospective Cohort Studies." Journal of the National Cancer Institute, vol. 102, no. 11, 2010, pp. 771-83.
Zhang X, Albanes D, Beeson WL, et al. Risk of colon cancer and coffee, tea, and sugar-sweetened soft drink intake: pooled analysis of prospective cohort studies. J Natl Cancer Inst. 2010;102(11):771-83.
Zhang, X., Albanes, D., Beeson, W. L., van den Brandt, P. A., Buring, J. E., Flood, A., Freudenheim, J. L., Giovannucci, E. L., Goldbohm, R. A., Jaceldo-Siegl, K., Jacobs, E. J., Krogh, V., Larsson, S. C., Marshall, J. R., McCullough, M. L., Miller, A. B., Robien, K., Rohan, T. E., Schatzkin, A., ... Smith-Warner, S. A. (2010). Risk of colon cancer and coffee, tea, and sugar-sweetened soft drink intake: pooled analysis of prospective cohort studies. Journal of the National Cancer Institute, 102(11), 771-83. https://doi.org/10.1093/jnci/djq107
Zhang X, et al. Risk of Colon Cancer and Coffee, Tea, and Sugar-sweetened Soft Drink Intake: Pooled Analysis of Prospective Cohort Studies. J Natl Cancer Inst. 2010 Jun 2;102(11):771-83. PubMed PMID: 20453203.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk of colon cancer and coffee, tea, and sugar-sweetened soft drink intake: pooled analysis of prospective cohort studies. AU - Zhang,Xuehong, AU - Albanes,Demetrius, AU - Beeson,W Lawrence, AU - van den Brandt,Piet A, AU - Buring,Julie E, AU - Flood,Andrew, AU - Freudenheim,Jo L, AU - Giovannucci,Edward L, AU - Goldbohm,R Alexandra, AU - Jaceldo-Siegl,Karen, AU - Jacobs,Eric J, AU - Krogh,Vittorio, AU - Larsson,Susanna C, AU - Marshall,James R, AU - McCullough,Marjorie L, AU - Miller,Anthony B, AU - Robien,Kim, AU - Rohan,Thomas E, AU - Schatzkin,Arthur, AU - Sieri,Sabina, AU - Spiegelman,Donna, AU - Virtamo,Jarmo, AU - Wolk,Alicja, AU - Willett,Walter C, AU - Zhang,Shumin M, AU - Smith-Warner,Stephanie A, Y1 - 2010/05/07/ PY - 2010/5/11/entrez PY - 2010/5/11/pubmed PY - 2010/6/15/medline SP - 771 EP - 83 JF - Journal of the National Cancer Institute JO - J Natl Cancer Inst VL - 102 IS - 11 N2 - BACKGROUND: The relationships between coffee, tea, and sugar-sweetened carbonated soft drink consumption and colon cancer risk remain unresolved. METHODS: We investigated prospectively the association between coffee, tea, and sugar-sweetened carbonated soft drink consumption and colon cancer risk in a pooled analysis of primary data from 13 cohort studies. Among 731 441 participants followed for up to 6-20 years, 5604 incident colon cancer case patients were identified. Study-specific relative risks (RRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models and then pooled using a random-effects model. All statistical tests were two-sided. RESULTS: Compared with nonconsumers, the pooled multivariable relative risks were 1.07 (95% CI = 0.89 to 1.30, P(trend) = .68) for coffee consumption greater than 1400 g/d (about six 8-oz cups) and 1.28 (95% CI = 1.02 to 1.61, P(trend) = .01) for tea consumption greater than 900 g/d (about four 8-oz cups). For sugar-sweetened carbonated soft drink consumption, the pooled multivariable relative risk comparing consumption greater than 550 g/d (about 18 oz) to nonconsumers was 0.94 (95% CI = 0.66 to 1.32, P(trend) = .91). No statistically significant between-studies heterogeneity was observed for the highest category of each beverage consumed (P > .20). The observed associations did not differ by sex, smoking status, alcohol consumption, body mass index, physical activity, or tumor site (P > .05). CONCLUSIONS: Drinking coffee or sugar-sweetened carbonated soft drinks was not associated with colon cancer risk. However, a modest positive association with higher tea consumption is possible and requires further study. SN - 1460-2105 UR - https://www.unboundmedicine.com/medline/citation/20453203/Risk_of_colon_cancer_and_coffee_tea_and_sugar_sweetened_soft_drink_intake:_pooled_analysis_of_prospective_cohort_studies_ L2 - https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnci/djq107 DB - PRIME DP - Unbound Medicine ER -