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Predictors of malignant intraductal papillary mucinous neoplasm of the pancreas.
J Clin Gastroenterol. 2010 Oct; 44(9):e224-9.JC

Abstract

GOALS

The predictors of malignant intraductal papillary mucinous neoplasm (IPMN) and invasive IPMN were investigated in this study to determine the optimal indicators of surgical resection for IPMN.

BACKGROUND

Recently, international consensus guidelines have described the standard indicators of resection for IPMN. However, the indicators of surgical resection for IPMN, especially for branch duct IPMN, still remain controversial.

STUDY

Eighty-two patients with IPMN who underwent surgical resection during April 1998 to January 2009, were retrospectively reviewed and examined with regard to their preoperative factors and pathologic diagnosis.

RESULTS

Multivariate analysis showed that main duct IPMN (P<0.01) and earlier diabetes (P=0.03) were independent predictors of malignant IPMN. In branch duct IPMN, the diameter of the main pancreatic duct (MPD) was found to be significantly associated with malignancy by univariate analysis (P=0.034). An elevated serum CA19-9 level (P<0.01) was an independent predictor of invasive IPMN.

CONCLUSIONS

Our observations suggest that main duct IPMN, branch duct IPMN with MPD dilatation, and IPMN with an elevated serum CA19-9 level should be considered as indications for surgical resection.

Authors+Show Affiliations

Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20453661

Citation

Mimura, Takuya, et al. "Predictors of Malignant Intraductal Papillary Mucinous Neoplasm of the Pancreas." Journal of Clinical Gastroenterology, vol. 44, no. 9, 2010, pp. e224-9.
Mimura T, Masuda A, Matsumoto I, et al. Predictors of malignant intraductal papillary mucinous neoplasm of the pancreas. J Clin Gastroenterol. 2010;44(9):e224-9.
Mimura, T., Masuda, A., Matsumoto, I., Shiomi, H., Yoshida, S., Sugimoto, M., Sanuki, T., Yoshida, M., Fujita, T., Kutsumi, H., Ku, Y., & Azuma, T. (2010). Predictors of malignant intraductal papillary mucinous neoplasm of the pancreas. Journal of Clinical Gastroenterology, 44(9), e224-9. https://doi.org/10.1097/MCG.0b013e3181d8fb91
Mimura T, et al. Predictors of Malignant Intraductal Papillary Mucinous Neoplasm of the Pancreas. J Clin Gastroenterol. 2010;44(9):e224-9. PubMed PMID: 20453661.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Predictors of malignant intraductal papillary mucinous neoplasm of the pancreas. AU - Mimura,Takuya, AU - Masuda,Atsuhiro, AU - Matsumoto,Ippei, AU - Shiomi,Hideyuki, AU - Yoshida,Shiei, AU - Sugimoto,Maki, AU - Sanuki,Tsuyoshi, AU - Yoshida,Masaru, AU - Fujita,Tsuyoshi, AU - Kutsumi,Hiromu, AU - Ku,Yonsou, AU - Azuma,Takeshi, PY - 2010/5/11/entrez PY - 2010/5/11/pubmed PY - 2011/1/6/medline SP - e224 EP - 9 JF - Journal of clinical gastroenterology JO - J Clin Gastroenterol VL - 44 IS - 9 N2 - GOALS: The predictors of malignant intraductal papillary mucinous neoplasm (IPMN) and invasive IPMN were investigated in this study to determine the optimal indicators of surgical resection for IPMN. BACKGROUND: Recently, international consensus guidelines have described the standard indicators of resection for IPMN. However, the indicators of surgical resection for IPMN, especially for branch duct IPMN, still remain controversial. STUDY: Eighty-two patients with IPMN who underwent surgical resection during April 1998 to January 2009, were retrospectively reviewed and examined with regard to their preoperative factors and pathologic diagnosis. RESULTS: Multivariate analysis showed that main duct IPMN (P<0.01) and earlier diabetes (P=0.03) were independent predictors of malignant IPMN. In branch duct IPMN, the diameter of the main pancreatic duct (MPD) was found to be significantly associated with malignancy by univariate analysis (P=0.034). An elevated serum CA19-9 level (P<0.01) was an independent predictor of invasive IPMN. CONCLUSIONS: Our observations suggest that main duct IPMN, branch duct IPMN with MPD dilatation, and IPMN with an elevated serum CA19-9 level should be considered as indications for surgical resection. SN - 1539-2031 UR - https://www.unboundmedicine.com/medline/citation/20453661/Predictors_of_malignant_intraductal_papillary_mucinous_neoplasm_of_the_pancreas_ DB - PRIME DP - Unbound Medicine ER -