TY - JOUR T1 - Predictors of malignant intraductal papillary mucinous neoplasm of the pancreas. AU - Mimura,Takuya, AU - Masuda,Atsuhiro, AU - Matsumoto,Ippei, AU - Shiomi,Hideyuki, AU - Yoshida,Shiei, AU - Sugimoto,Maki, AU - Sanuki,Tsuyoshi, AU - Yoshida,Masaru, AU - Fujita,Tsuyoshi, AU - Kutsumi,Hiromu, AU - Ku,Yonsou, AU - Azuma,Takeshi, PY - 2010/5/11/entrez PY - 2010/5/11/pubmed PY - 2011/1/6/medline SP - e224 EP - 9 JF - Journal of clinical gastroenterology JO - J Clin Gastroenterol VL - 44 IS - 9 N2 - GOALS: The predictors of malignant intraductal papillary mucinous neoplasm (IPMN) and invasive IPMN were investigated in this study to determine the optimal indicators of surgical resection for IPMN. BACKGROUND: Recently, international consensus guidelines have described the standard indicators of resection for IPMN. However, the indicators of surgical resection for IPMN, especially for branch duct IPMN, still remain controversial. STUDY: Eighty-two patients with IPMN who underwent surgical resection during April 1998 to January 2009, were retrospectively reviewed and examined with regard to their preoperative factors and pathologic diagnosis. RESULTS: Multivariate analysis showed that main duct IPMN (P<0.01) and earlier diabetes (P=0.03) were independent predictors of malignant IPMN. In branch duct IPMN, the diameter of the main pancreatic duct (MPD) was found to be significantly associated with malignancy by univariate analysis (P=0.034). An elevated serum CA19-9 level (P<0.01) was an independent predictor of invasive IPMN. CONCLUSIONS: Our observations suggest that main duct IPMN, branch duct IPMN with MPD dilatation, and IPMN with an elevated serum CA19-9 level should be considered as indications for surgical resection. SN - 1539-2031 UR - https://www.unboundmedicine.com/medline/citation/20453661/Predictors_of_malignant_intraductal_papillary_mucinous_neoplasm_of_the_pancreas_ DB - PRIME DP - Unbound Medicine ER -