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Comparison of manual and automated determination of hippocampal volumes in MCI and early AD.
Brain Imaging Behav 2010; 4(1):86-95BI

Abstract

MRI-based hippocampal volume analysis has been extensively employed given its potential as a biomarker for brain disorders such as Alzheimer's disease (AD), and accurate and efficient determination of hippocampal volumes from brain images is still a challenging issue. We compared an automated method, FreeSurfer (V4), with a published manual protocol for the determination of hippocampal volumes from T1-weighted MRI scans. Our study included MRI data from 125 older adult subjects: healthy controls with no significant cognitive complaints or deficits (HC, n=38), euthymic individuals with cognitive complaints (CC, n=39) but intact neuropsychological performance, and patients with amnestic mild cognitive impairment (MCI, n=37) or a clinical diagnosis of probable AD (AD, n=11). Pearson correlations and intraclass correlation coefficients (ICCs) were calculated to evaluate the relationship between results of the manual tracing and FreeSurfer methods and to estimate their agreement. Results indicated that these two methods derived highly correlated results with strong agreement. After controlling for the age, sex and intracranial volume in statistical group analysis, both the manual tracing and FreeSurfer methods yield similar patterns: both the MCI group and the AD group showed hippocampal volume reduction compared to both the HC group and the CC group, and the HC and CC groups did not differ. These comparisons suggest that FreeSurfer has the potential to be used in automated determination of hippocampal volumes for large-scale MCI/AD-related MRI studies, where manual methods are inefficient or not feasible.

Authors+Show Affiliations

IU Center for Neuroimaging, Div. of Imaging Sciences, Dept. of Radiology, Indiana University School of Medicine, 950 W Walnut St., R2 E124, Indianapolis, IN 46202, USA. shenli@iupui.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20454594

Citation

Shen, Li, et al. "Comparison of Manual and Automated Determination of Hippocampal Volumes in MCI and Early AD." Brain Imaging and Behavior, vol. 4, no. 1, 2010, pp. 86-95.
Shen L, Saykin AJ, Kim S, et al. Comparison of manual and automated determination of hippocampal volumes in MCI and early AD. Brain Imaging Behav. 2010;4(1):86-95.
Shen, L., Saykin, A. J., Kim, S., Firpi, H. A., West, J. D., Risacher, S. L., ... Flashman, L. A. (2010). Comparison of manual and automated determination of hippocampal volumes in MCI and early AD. Brain Imaging and Behavior, 4(1), pp. 86-95. doi:10.1007/s11682-010-9088-x.
Shen L, et al. Comparison of Manual and Automated Determination of Hippocampal Volumes in MCI and Early AD. Brain Imaging Behav. 2010;4(1):86-95. PubMed PMID: 20454594.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of manual and automated determination of hippocampal volumes in MCI and early AD. AU - Shen,Li, AU - Saykin,Andrew J, AU - Kim,Sungeun, AU - Firpi,Hiram A, AU - West,John D, AU - Risacher,Shannon L, AU - McDonald,Brenna C, AU - McHugh,Tara L, AU - Wishart,Heather A, AU - Flashman,Laura A, PY - 2010/5/11/entrez PY - 2010/5/11/pubmed PY - 2010/8/25/medline KW - Alzheimer’s disease KW - Magnetic resonance imaging KW - cognitive complaints KW - hippocampus KW - mild cognitive impairment KW - segmentation SP - 86 EP - 95 JF - Brain imaging and behavior JO - Brain Imaging Behav VL - 4 IS - 1 N2 - MRI-based hippocampal volume analysis has been extensively employed given its potential as a biomarker for brain disorders such as Alzheimer's disease (AD), and accurate and efficient determination of hippocampal volumes from brain images is still a challenging issue. We compared an automated method, FreeSurfer (V4), with a published manual protocol for the determination of hippocampal volumes from T1-weighted MRI scans. Our study included MRI data from 125 older adult subjects: healthy controls with no significant cognitive complaints or deficits (HC, n=38), euthymic individuals with cognitive complaints (CC, n=39) but intact neuropsychological performance, and patients with amnestic mild cognitive impairment (MCI, n=37) or a clinical diagnosis of probable AD (AD, n=11). Pearson correlations and intraclass correlation coefficients (ICCs) were calculated to evaluate the relationship between results of the manual tracing and FreeSurfer methods and to estimate their agreement. Results indicated that these two methods derived highly correlated results with strong agreement. After controlling for the age, sex and intracranial volume in statistical group analysis, both the manual tracing and FreeSurfer methods yield similar patterns: both the MCI group and the AD group showed hippocampal volume reduction compared to both the HC group and the CC group, and the HC and CC groups did not differ. These comparisons suggest that FreeSurfer has the potential to be used in automated determination of hippocampal volumes for large-scale MCI/AD-related MRI studies, where manual methods are inefficient or not feasible. SN - 1931-7565 UR - https://www.unboundmedicine.com/medline/citation/20454594/Comparison_of_manual_and_automated_determination_of_hippocampal_volumes_in_MCI_and_early_AD_ L2 - https://dx.doi.org/10.1007/s11682-010-9088-x DB - PRIME DP - Unbound Medicine ER -