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Gene- and cell-based approaches for neurodegenerative disease.
Adv Exp Med Biol. 2010; 671:117-30.AE

Abstract

Neurodegenerative diseases comprise an important group ofchronic diseases that increase in incidence with rising age. In particular, the two most common neurodegenerative diseases are Alzheimer's disease and Parkinson's disease, both of which will be discussed below. A third, Huntington's disease, occurs infrequently, but has been studied intensely. Each of these diseases shares characteristics which are also generalizeable to other neurodegenerative diseases: accumulation ofproteinaceous substances that leads inexorably to selective neuronal death and decline in neural function. Treatments for these diseases have historically focused on symptomatic relief, but recent advances in molecular research have identified more specific targets. Additionally, stem cell therapy, immunotherapy and trophic-factor delivery provide avenues for neuronal protection that may alter the natural progression of these devastating illnesses. Upcoming clinical trials will evaluate treatment strategies and provide hope that translational research will decrease the onset of debilitating disability associated with neurodegenerative disease.

Authors+Show Affiliations

Urbaniak Hunter K
Department of Radiation Oncology, Univesity of Michigan, Ann Arbor, Michigan, USA. kurbania@med.umich.edu
Yarbrough C
No affiliation info available
Ciacci J
No affiliation info available

MeSH

Alzheimer DiseaseGenetic TherapyHumansImmunotherapyNeurodegenerative DiseasesParkinson DiseaseStem Cell Transplantation

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20455500

Citation

Urbaniak Hunter, Klaudia, et al. "Gene- and Cell-based Approaches for Neurodegenerative Disease." Advances in Experimental Medicine and Biology, vol. 671, 2010, pp. 117-30.
Urbaniak Hunter K, Yarbrough C, Ciacci J. Gene- and cell-based approaches for neurodegenerative disease. Adv Exp Med Biol. 2010;671:117-30.
Urbaniak Hunter, K., Yarbrough, C., & Ciacci, J. (2010). Gene- and cell-based approaches for neurodegenerative disease. Advances in Experimental Medicine and Biology, 671, 117-30.
Urbaniak Hunter K, Yarbrough C, Ciacci J. Gene- and Cell-based Approaches for Neurodegenerative Disease. Adv Exp Med Biol. 2010;671:117-30. PubMed PMID: 20455500.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gene- and cell-based approaches for neurodegenerative disease. AU - Urbaniak Hunter,Klaudia, AU - Yarbrough,Chester, AU - Ciacci,Joseph, PY - 2010/5/12/entrez PY - 2010/5/12/pubmed PY - 2010/6/2/medline SP - 117 EP - 30 JF - Advances in experimental medicine and biology JO - Adv Exp Med Biol VL - 671 N2 - Neurodegenerative diseases comprise an important group ofchronic diseases that increase in incidence with rising age. In particular, the two most common neurodegenerative diseases are Alzheimer's disease and Parkinson's disease, both of which will be discussed below. A third, Huntington's disease, occurs infrequently, but has been studied intensely. Each of these diseases shares characteristics which are also generalizeable to other neurodegenerative diseases: accumulation ofproteinaceous substances that leads inexorably to selective neuronal death and decline in neural function. Treatments for these diseases have historically focused on symptomatic relief, but recent advances in molecular research have identified more specific targets. Additionally, stem cell therapy, immunotherapy and trophic-factor delivery provide avenues for neuronal protection that may alter the natural progression of these devastating illnesses. Upcoming clinical trials will evaluate treatment strategies and provide hope that translational research will decrease the onset of debilitating disability associated with neurodegenerative disease. SN - 0065-2598 UR - https://www.unboundmedicine.com/medline/citation/20455500/Gene__and_cell_based_approaches_for_neurodegenerative_disease_ L2 - https://dx.doi.org/10.1007/978-1-4419-5819-8_10 DB - PRIME DP - Unbound Medicine ER -