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Incidence and morbidity of human metapneumovirus and other community-acquired respiratory viruses in lung transplant recipients.
Transpl Infect Dis. 2010 Aug 01; 12(4):330-5.TI

Abstract

To determine the role of human metapneumovirus (HMPV) in respiratory tract infections (RTIs) of lung transplant recipients, 60 patients were prospectively enrolled in this study spanning from September 2005 to November 2007. Community-acquired respiratory viruses (CARVs) were identified by polymerase chain reaction and tissue culture in respiratory secretions. Of 112 RTIs, 51 were associated with > or =1 CARV, including 7 HMPV, 13 respiratory syncytial virus (RSV), 19 parainfluenza virus 1, 2, or 3 (PIV), 16 influenza A or B (FLU), and 3 human rhinoviruses (HRV). Sixteen CARV-RTIs had multiple pathogens. While the standard protocol was to admit all paramyxoviral RTIs for inhaled ribavirin, 16% CARV-RTIs required hospitalization because of the severity of their respiratory compromise, including 25% of HPMV-single-agent RTI, 38% of RSV single-agent RTI, 10% of PIV-single-agent RTI, and 19% of multiple-agent RTIs. None of those with non-CARV RTIs required hospitalization. The incidence of clinically diagnosed acute graft rejection in the first 2 months after an RTI varied from 0 for single-agent HRV to 88% for single-agent RSV (25% for single-agent HMPV). A new diagnosis of chronic graft rejection in the first year after an RTI was made in approximately 25% of the RTIs and did not significantly vary with the etiologic agent. No deaths occurred during this study. In conclusion, HMPV was associated with 6% of the RTIs in lung transplant recipients and its morbidity was similar to the average moribidity of CARVs.

Authors+Show Affiliations

Department of Pediatrics, University of Colorado Denver, Aurora, CO 80045,, USA. adriana.weinberg@ucdenver.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20456714

Citation

Weinberg, A, et al. "Incidence and Morbidity of Human Metapneumovirus and Other Community-acquired Respiratory Viruses in Lung Transplant Recipients." Transplant Infectious Disease : an Official Journal of the Transplantation Society, vol. 12, no. 4, 2010, pp. 330-5.
Weinberg A, Lyu DM, Li S, et al. Incidence and morbidity of human metapneumovirus and other community-acquired respiratory viruses in lung transplant recipients. Transpl Infect Dis. 2010;12(4):330-5.
Weinberg, A., Lyu, D. M., Li, S., Marquesen, J., & Zamora, M. R. (2010). Incidence and morbidity of human metapneumovirus and other community-acquired respiratory viruses in lung transplant recipients. Transplant Infectious Disease : an Official Journal of the Transplantation Society, 12(4), 330-5. https://doi.org/10.1111/j.1399-3062.2010.00509.x
Weinberg A, et al. Incidence and Morbidity of Human Metapneumovirus and Other Community-acquired Respiratory Viruses in Lung Transplant Recipients. Transpl Infect Dis. 2010 Aug 1;12(4):330-5. PubMed PMID: 20456714.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Incidence and morbidity of human metapneumovirus and other community-acquired respiratory viruses in lung transplant recipients. AU - Weinberg,A, AU - Lyu,D M, AU - Li,S, AU - Marquesen,J, AU - Zamora,M R, Y1 - 2010/04/29/ PY - 2010/5/12/entrez PY - 2010/5/12/pubmed PY - 2011/1/13/medline SP - 330 EP - 5 JF - Transplant infectious disease : an official journal of the Transplantation Society JO - Transpl Infect Dis VL - 12 IS - 4 N2 - To determine the role of human metapneumovirus (HMPV) in respiratory tract infections (RTIs) of lung transplant recipients, 60 patients were prospectively enrolled in this study spanning from September 2005 to November 2007. Community-acquired respiratory viruses (CARVs) were identified by polymerase chain reaction and tissue culture in respiratory secretions. Of 112 RTIs, 51 were associated with > or =1 CARV, including 7 HMPV, 13 respiratory syncytial virus (RSV), 19 parainfluenza virus 1, 2, or 3 (PIV), 16 influenza A or B (FLU), and 3 human rhinoviruses (HRV). Sixteen CARV-RTIs had multiple pathogens. While the standard protocol was to admit all paramyxoviral RTIs for inhaled ribavirin, 16% CARV-RTIs required hospitalization because of the severity of their respiratory compromise, including 25% of HPMV-single-agent RTI, 38% of RSV single-agent RTI, 10% of PIV-single-agent RTI, and 19% of multiple-agent RTIs. None of those with non-CARV RTIs required hospitalization. The incidence of clinically diagnosed acute graft rejection in the first 2 months after an RTI varied from 0 for single-agent HRV to 88% for single-agent RSV (25% for single-agent HMPV). A new diagnosis of chronic graft rejection in the first year after an RTI was made in approximately 25% of the RTIs and did not significantly vary with the etiologic agent. No deaths occurred during this study. In conclusion, HMPV was associated with 6% of the RTIs in lung transplant recipients and its morbidity was similar to the average moribidity of CARVs. SN - 1399-3062 UR - https://www.unboundmedicine.com/medline/citation/20456714/Incidence_and_morbidity_of_human_metapneumovirus_and_other_community_acquired_respiratory_viruses_in_lung_transplant_recipients_ L2 - https://doi.org/10.1111/j.1399-3062.2010.00509.x DB - PRIME DP - Unbound Medicine ER -