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Carvedilol treatment ameliorates acute coxsackievirus B3-induced myocarditis associated with oxidative stress reduction.
Eur J Pharmacol. 2010 Aug 25; 640(1-3):112-6.EJ

Abstract

Oxidative stress has been implicated in the pathogenesis of acute myocarditis. The imbalance between the occurrence of reactive oxygen species and the cellular antioxidant defense mechanism plays a key role in myocardial injury of viral myocarditis. Carvedilol, a nonselective beta-adrenoceptor antagonist with additional alpha1-adrenergic blocking and antioxidant properties, has been shown to be cardioprotective in experimental myocarditis. However, the expression of 4-hydroxy-2-nonenal (4-HNE), the most reliable marker of lipid peroxidation, has not been studied, and the antioxidative effects of carvedilol have not been investigated in the setting of acute viral myocarditis. This study was therefore designed to determine whether levels of lipid peroxides are elevated in the myocardium and whether carvedilol reduces the lipid peroxidation level and increases antioxidant enzyme activities. In a coxsackievirus B3 murine myocarditis model (Balb/c), effects of carvedilol and metoprolol on 14-day survival rate, myocardial histopathological changes, cardiac function, the expression of 4-HNE, virus titers, malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidases (GSH-Px) activities were studied. Lipid peroxidations including 4-HNE and MDA, were elevated in murine coxsackievirus-induced acute viral myocarditis. Carvedilol, but not metoprolol, improved survival, reduced lipid peroxidations including 4-HNE and MDA, and increased antioxidant enzyme activities including SOD and GSH-Px with amelioration of acute viral myocarditis. These results show that carvedilol but not metoprolol exerts some of its beneficial effects by inhibiting peroxidants.

Authors+Show Affiliations

Department of Cardiology, Second Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China. liyuechun1980@sina.com.cnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20457150

Citation

Li, Yue-Chun, et al. "Carvedilol Treatment Ameliorates Acute Coxsackievirus B3-induced Myocarditis Associated With Oxidative Stress Reduction." European Journal of Pharmacology, vol. 640, no. 1-3, 2010, pp. 112-6.
Li YC, Ge LS, Yang PL, et al. Carvedilol treatment ameliorates acute coxsackievirus B3-induced myocarditis associated with oxidative stress reduction. Eur J Pharmacol. 2010;640(1-3):112-6.
Li, Y. C., Ge, L. S., Yang, P. L., Tang, J. F., Lin, J. F., Chen, P., & Guan, X. Q. (2010). Carvedilol treatment ameliorates acute coxsackievirus B3-induced myocarditis associated with oxidative stress reduction. European Journal of Pharmacology, 640(1-3), 112-6. https://doi.org/10.1016/j.ejphar.2010.04.037
Li YC, et al. Carvedilol Treatment Ameliorates Acute Coxsackievirus B3-induced Myocarditis Associated With Oxidative Stress Reduction. Eur J Pharmacol. 2010 Aug 25;640(1-3):112-6. PubMed PMID: 20457150.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Carvedilol treatment ameliorates acute coxsackievirus B3-induced myocarditis associated with oxidative stress reduction. AU - Li,Yue-Chun, AU - Ge,Li-Sha, AU - Yang,Peng-Lin, AU - Tang,Ji-Fei, AU - Lin,Jia-Feng, AU - Chen,Peng, AU - Guan,Xue-qiang, Y1 - 2010/05/08/ PY - 2009/10/07/received PY - 2010/04/04/revised PY - 2010/04/24/accepted PY - 2010/5/12/entrez PY - 2010/5/12/pubmed PY - 2010/10/5/medline SP - 112 EP - 6 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 640 IS - 1-3 N2 - Oxidative stress has been implicated in the pathogenesis of acute myocarditis. The imbalance between the occurrence of reactive oxygen species and the cellular antioxidant defense mechanism plays a key role in myocardial injury of viral myocarditis. Carvedilol, a nonselective beta-adrenoceptor antagonist with additional alpha1-adrenergic blocking and antioxidant properties, has been shown to be cardioprotective in experimental myocarditis. However, the expression of 4-hydroxy-2-nonenal (4-HNE), the most reliable marker of lipid peroxidation, has not been studied, and the antioxidative effects of carvedilol have not been investigated in the setting of acute viral myocarditis. This study was therefore designed to determine whether levels of lipid peroxides are elevated in the myocardium and whether carvedilol reduces the lipid peroxidation level and increases antioxidant enzyme activities. In a coxsackievirus B3 murine myocarditis model (Balb/c), effects of carvedilol and metoprolol on 14-day survival rate, myocardial histopathological changes, cardiac function, the expression of 4-HNE, virus titers, malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidases (GSH-Px) activities were studied. Lipid peroxidations including 4-HNE and MDA, were elevated in murine coxsackievirus-induced acute viral myocarditis. Carvedilol, but not metoprolol, improved survival, reduced lipid peroxidations including 4-HNE and MDA, and increased antioxidant enzyme activities including SOD and GSH-Px with amelioration of acute viral myocarditis. These results show that carvedilol but not metoprolol exerts some of its beneficial effects by inhibiting peroxidants. SN - 1879-0712 UR - https://www.unboundmedicine.com/medline/citation/20457150/Carvedilol_treatment_ameliorates_acute_coxsackievirus_B3_induced_myocarditis_associated_with_oxidative_stress_reduction_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(10)00368-7 DB - PRIME DP - Unbound Medicine ER -