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Mitigating effects of antioxidant properties of Artemisia campestris leaf extract on hyperlipidemia, advanced glycation end products and oxidative stress in alloxan-induced diabetic rats.
Food Chem Toxicol. 2010 Jul; 48(7):1986-93.FC

Abstract

Artemisia campestris is used as antivenom and anti-inflammatory Tunisian folk medicine. Recently, increased oxidative stress was shown to play an important role in the etiology and pathogenesis of diabetes mellitus and its complications. This study was designed to examine the effects of A. campestris leaf aqueous extract (Ac) on alloxan-induced diabetic rats by measuring glycemia, lipid profile, lipid peroxidation (MDA), protein carbonyl content (PCO), advanced oxidation protein products (AOPP), activities of both non-enzymatic and enzymatic antioxidants. Results of our study showed an increase in blood glucose levels, total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-c), a decrease in high-density lipoprotein cholesterol (HDL-c) level and disturbed antioxidant enzyme activities (CAT, SOD, GPx) in the pancreatic tissue of diabetic rats. Furthermore, MDA, PCO and AOPP were elevated in the pancreas of the diabetic rats. The administration of Ac to diabetic rats at a dose of 200mgkg(-1)bw resulted in a significant reduction in glycemia, TC, TG, LDL-c, pancreas LPO, PCO and AOPP levels, CAT and GPx activities associated with an elevation of GSH content and SOD activity in comparison with diabetic group. We conclude that A. campestris aqueous extract may be effective for correcting hyperglycemia and preventing diabetic complications.

Authors+Show Affiliations

Animal Physiology Laboratory, Sciences Faculty, BP 1171, 3000 Sfax, Tunisia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20457207

Citation

Sefi, Mediha, et al. "Mitigating Effects of Antioxidant Properties of Artemisia Campestris Leaf Extract On Hyperlipidemia, Advanced Glycation End Products and Oxidative Stress in Alloxan-induced Diabetic Rats." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 48, no. 7, 2010, pp. 1986-93.
Sefi M, Fetoui H, Makni M, et al. Mitigating effects of antioxidant properties of Artemisia campestris leaf extract on hyperlipidemia, advanced glycation end products and oxidative stress in alloxan-induced diabetic rats. Food Chem Toxicol. 2010;48(7):1986-93.
Sefi, M., Fetoui, H., Makni, M., & Zeghal, N. (2010). Mitigating effects of antioxidant properties of Artemisia campestris leaf extract on hyperlipidemia, advanced glycation end products and oxidative stress in alloxan-induced diabetic rats. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 48(7), 1986-93. https://doi.org/10.1016/j.fct.2010.05.005
Sefi M, et al. Mitigating Effects of Antioxidant Properties of Artemisia Campestris Leaf Extract On Hyperlipidemia, Advanced Glycation End Products and Oxidative Stress in Alloxan-induced Diabetic Rats. Food Chem Toxicol. 2010;48(7):1986-93. PubMed PMID: 20457207.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mitigating effects of antioxidant properties of Artemisia campestris leaf extract on hyperlipidemia, advanced glycation end products and oxidative stress in alloxan-induced diabetic rats. AU - Sefi,Mediha, AU - Fetoui,Hamadi, AU - Makni,Mohamed, AU - Zeghal,Najiba, Y1 - 2010/05/08/ PY - 2010/02/18/received PY - 2010/04/19/revised PY - 2010/05/03/accepted PY - 2010/5/12/entrez PY - 2010/5/12/pubmed PY - 2010/12/14/medline SP - 1986 EP - 93 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 48 IS - 7 N2 - Artemisia campestris is used as antivenom and anti-inflammatory Tunisian folk medicine. Recently, increased oxidative stress was shown to play an important role in the etiology and pathogenesis of diabetes mellitus and its complications. This study was designed to examine the effects of A. campestris leaf aqueous extract (Ac) on alloxan-induced diabetic rats by measuring glycemia, lipid profile, lipid peroxidation (MDA), protein carbonyl content (PCO), advanced oxidation protein products (AOPP), activities of both non-enzymatic and enzymatic antioxidants. Results of our study showed an increase in blood glucose levels, total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-c), a decrease in high-density lipoprotein cholesterol (HDL-c) level and disturbed antioxidant enzyme activities (CAT, SOD, GPx) in the pancreatic tissue of diabetic rats. Furthermore, MDA, PCO and AOPP were elevated in the pancreas of the diabetic rats. The administration of Ac to diabetic rats at a dose of 200mgkg(-1)bw resulted in a significant reduction in glycemia, TC, TG, LDL-c, pancreas LPO, PCO and AOPP levels, CAT and GPx activities associated with an elevation of GSH content and SOD activity in comparison with diabetic group. We conclude that A. campestris aqueous extract may be effective for correcting hyperglycemia and preventing diabetic complications. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/20457207/Mitigating_effects_of_antioxidant_properties_of_Artemisia_campestris_leaf_extract_on_hyperlipidemia_advanced_glycation_end_products_and_oxidative_stress_in_alloxan_induced_diabetic_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(10)00280-2 DB - PRIME DP - Unbound Medicine ER -