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Family study of restless legs syndrome in Quebec, Canada: clinical characterization of 671 familial cases.
Arch Neurol 2010; 67(5):617-22AN

Abstract

OBJECTIVES

To fully ascertain the familial aggregation of restless legs syndrome (RLS) and to characterize the clinical features of familial RLS (fRLS) cases.

DESIGN

A case series survey with a high response rate.

SETTING

Academic research center.

PARTICIPANTS

Consecutive RLS probands (n = 249) were followed up in a specialized sleep center for 15 years. A total of 671 cases of fRLS met the current standard diagnostic criteria, including 192 probands characterized using multidimensional clinical assessments and 479 affected family members assessed by their responses to a structured questionnaire telephone diagnostic interview.

MAIN OUTCOME MEASURES

Sibling and offspring relative risk ratio and clinical and genetic features of patients with fRLS and families.

RESULTS

Our data showed that RLS aggregates in families with a familial rate of 77%, a sibling relative risk of 3.6 (95% confidence interval, 2.8-4.4), and an offspring relative risk of 1.8 (1.0-2.7). Familial RLS is a chronic disorder with a mean (SD) disease duration of 24 (16) years and a wide range of age of onset (mean [SD], 28 [15] years), with most family members having early-onset disease but mild to moderate RLS symptoms. Our clinical data also indicated that fRLS is more prominent among women who also had increased incidence of anemia/iron deficiency, arthritis, and number of pregnancies. Pregnancy-related RLS seems to be a characteristic feature of fRLS, and afflicted women tend to have a much younger age of onset.

CONCLUSIONS

Restless legs syndrome significantly aggregated in families with variable phenotypic expressivity, and the siblings of severely affected individuals have an increased risk of developing the disease.

Authors+Show Affiliations

Center of Excellence in Neuromics, Research Centre of the University of Montreal Hospital Centre, and the Department of Medicine, University of Montreal, Montréal, Québec Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20457962

Citation

Xiong, Lan, et al. "Family Study of Restless Legs Syndrome in Quebec, Canada: Clinical Characterization of 671 Familial Cases." Archives of Neurology, vol. 67, no. 5, 2010, pp. 617-22.
Xiong L, Montplaisir J, Desautels A, et al. Family study of restless legs syndrome in Quebec, Canada: clinical characterization of 671 familial cases. Arch Neurol. 2010;67(5):617-22.
Xiong, L., Montplaisir, J., Desautels, A., Barhdadi, A., Turecki, G., Levchenko, A., ... Rouleau, G. A. (2010). Family study of restless legs syndrome in Quebec, Canada: clinical characterization of 671 familial cases. Archives of Neurology, 67(5), pp. 617-22. doi:10.1001/archneurol.2010.67.
Xiong L, et al. Family Study of Restless Legs Syndrome in Quebec, Canada: Clinical Characterization of 671 Familial Cases. Arch Neurol. 2010;67(5):617-22. PubMed PMID: 20457962.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Family study of restless legs syndrome in Quebec, Canada: clinical characterization of 671 familial cases. AU - Xiong,Lan, AU - Montplaisir,Jacques, AU - Desautels,Alex, AU - Barhdadi,Amina, AU - Turecki,Gustavo, AU - Levchenko,Anastasia, AU - Thibodeau,Pascale, AU - Dubé,Marie-Pierre, AU - Gaspar,Claudia, AU - Rouleau,Guy A, PY - 2010/5/12/entrez PY - 2010/5/12/pubmed PY - 2010/7/2/medline SP - 617 EP - 22 JF - Archives of neurology JO - Arch. Neurol. VL - 67 IS - 5 N2 - OBJECTIVES: To fully ascertain the familial aggregation of restless legs syndrome (RLS) and to characterize the clinical features of familial RLS (fRLS) cases. DESIGN: A case series survey with a high response rate. SETTING: Academic research center. PARTICIPANTS: Consecutive RLS probands (n = 249) were followed up in a specialized sleep center for 15 years. A total of 671 cases of fRLS met the current standard diagnostic criteria, including 192 probands characterized using multidimensional clinical assessments and 479 affected family members assessed by their responses to a structured questionnaire telephone diagnostic interview. MAIN OUTCOME MEASURES: Sibling and offspring relative risk ratio and clinical and genetic features of patients with fRLS and families. RESULTS: Our data showed that RLS aggregates in families with a familial rate of 77%, a sibling relative risk of 3.6 (95% confidence interval, 2.8-4.4), and an offspring relative risk of 1.8 (1.0-2.7). Familial RLS is a chronic disorder with a mean (SD) disease duration of 24 (16) years and a wide range of age of onset (mean [SD], 28 [15] years), with most family members having early-onset disease but mild to moderate RLS symptoms. Our clinical data also indicated that fRLS is more prominent among women who also had increased incidence of anemia/iron deficiency, arthritis, and number of pregnancies. Pregnancy-related RLS seems to be a characteristic feature of fRLS, and afflicted women tend to have a much younger age of onset. CONCLUSIONS: Restless legs syndrome significantly aggregated in families with variable phenotypic expressivity, and the siblings of severely affected individuals have an increased risk of developing the disease. SN - 1538-3687 UR - https://www.unboundmedicine.com/medline/citation/20457962/Family_study_of_restless_legs_syndrome_in_Quebec_Canada:_clinical_characterization_of_671_familial_cases_ L2 - https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/archneurol.2010.67 DB - PRIME DP - Unbound Medicine ER -